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公开(公告)号：US20050136064A1
公开(公告)日：2005-06-23
申请号：US11049848
申请日：2005-02-02
申请人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
发明人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
IPC分类号： A61K9/127 , A61K51/12 , A61K39/395 , C07K16/46 , C12N9/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
摘要翻译： 描述了用于制备对目标细胞敏化的治疗性脂质体组合物的试剂。 试剂包括由预先形成的脂质体组成的脂质体组合物，其具有包埋的治疗剂和由脂质，亲水性聚合物和靶向配体组成的多种靶向缀合物。 通过将脂质体组合物与所选择的缀合物孵育来形成治疗性靶细胞致敏脂质体组合物。
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公开(公告)号：US20060246126A1
公开(公告)日：2006-11-02
申请号：US11479437
申请日：2006-06-30
申请人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
发明人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
IPC分类号： A61K39/395 , A61K9/127 , C07K16/46
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
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公开(公告)号：US20050169980A1
公开(公告)日：2005-08-04
申请号：US11050012
申请日：2005-02-02
申请人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
发明人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
IPC分类号： A61K9/127 , A61K51/12 , A61K39/395
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
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公开(公告)号：US20060240009A1
公开(公告)日：2006-10-26
申请号：US11472140
申请日：2006-06-20
申请人： Samuel Zalipsky , Theresa Allen , Shi Huang
发明人： Samuel Zalipsky , Theresa Allen , Shi Huang
IPC分类号： A61K39/395 , A61K9/127
CPC分类号： A61K9/1272 , A61K9/1271 , A61K47/6913
摘要： A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and include a targeting ligand to direct the liposomes to a target cell. The liposomes also include a stabilizing component, such a polymer-derivatized lipid, where the polymer is attached to the lipid by a releasable linkage. Administration of the liposomes results in cellular internalization and destabilization of the liposome for intracellular delivery of the entrapped agent.
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公开(公告)号：US06870028B1
公开(公告)日：2005-03-22
申请号：US09593417
申请日：2000-06-14
申请人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michael Roberge , Theresa Allen
发明人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michael Roberge , Theresa Allen
CPC分类号： C07K5/0205 , A61K38/00 , C07K5/0827
摘要： This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, wherein Y, n, R1, R2, R3, R6, R7, R70, R71, R72, R74, and R75 are as defined in the specification.
摘要翻译： 本发明涉及具有抗有丝分裂活性并可用于治疗癌症的半球蛋白或衍生物的衍生物。 这些衍生物由通式I表示，其中Y，n，R 1，R 2，R 3，R 6，R 7，R 70，R 71，R 72，R 74和R 75如说明书中所定义。
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公开(公告)号：US07410951B2
公开(公告)日：2008-08-12
申请号：US11034922
申请日：2005-01-14
申请人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
发明人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
IPC分类号： C07K5/06
CPC分类号： C07K5/0205 , A61K38/00 , C07K5/0827
摘要： Derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by formula I wherein Y, n, R1, R2, R3, R7, R70, R71, R72, R74, and R75 are as defined in the specification.
摘要翻译： 具有抗有丝分裂活性并可用于治疗癌症的半精球蛋白或地高二聚G的衍生物。 这些衍生物由式I表示，其中Y，n，R 1，R 2，R 3，R 7， ，R 70，R 71，R 72，R 74和R 75， SUB>如说明书中所定义。
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公开(公告)号：US07772397B2
公开(公告)日：2010-08-10
申请号：US12176716
申请日：2008-07-21
申请人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
发明人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
IPC分类号： C07D471/04
CPC分类号： C07K5/0205 , A61K38/00 , C07K5/0827
摘要： This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, wherein Y, n, R1, R2, R3, R6, R7, R70, R71, R72, R74, and R75 are as defined in the specification.
摘要翻译： 本发明涉及具有抗有丝分裂活性并可用于治疗癌症的半球蛋白或衍生物的衍生物。 这些衍生物由通式I表示，其中Y，n，R 1，R 2，R 3，R 6，R 7，R 70，R 71，R 72，R 74和R 75如说明书中所定义。
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公开(公告)号：US20090088573A1
公开(公告)日：2009-04-02
申请号：US12176716
申请日：2008-07-21
申请人： Raymond ANDERSEN , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
发明人： Raymond ANDERSEN , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
IPC分类号： C07D471/04
CPC分类号： C07K5/0205 , A61K38/00 , C07K5/0827
摘要： This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, wherein Y, n, R1, R2, R3, R6, R7, R70, R71, R72, R74, and R75 are as defined in the specification.
摘要翻译： 本发明涉及具有抗有丝分裂活性并可用于治疗癌症的半球蛋白或衍生物的衍生物。 这些衍生物由通式I表示，其中Y，n，R 1，R 2，R 3，R 6，R 7，R 70，R 71，R 72，R 74和R 75如说明书中所定义。
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