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公开(公告)号：US5310649A
公开(公告)日：1994-05-10
申请号：US527017
申请日：1990-05-22
申请人： Thomas A. Ficht , Blair A. Sowa , L. Garry Adams
发明人： Thomas A. Ficht , Blair A. Sowa , L. Garry Adams
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , Y10S436/811
摘要： A method for detecting Brucella infection in an animal which is reliable, rapid, and able to identify species and biovars of Brucella. The detection method includes the amplification of the omp2 gene locus of Brucella and analysis of restriction digestion fragments specific to Brucella and to individual species and groups of biovars of Brucella.
摘要翻译： 一种用于检测动物中布鲁杆菌感染的方法，其可靠，快速，能够鉴定布鲁杆菌的物种和生物物种。 该检测方法包括扩增布鲁杆菌的omp2基因位点，并分析Brucella特异性的限制性消化片段以及Brucella的个体物种和生物群组。
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2.发明授权Vaccine comprising Brucella abortus which has O polysaccharide antigen absent 失效含有O多糖抗原的布鲁氏菌流产的疫苗不存在
公开(公告)号：US5718903A
公开(公告)日：1998-02-17
申请号：US196777
申请日：1994-02-14
申请人： Leslie Garry Adams , Richard P. Crawford , Donald S. Davis , Thomas A. Ficht , Roger Smith, III , Blair A. Sowa , Joe W. Templeton , John D. Williams , Albert M. Wu
发明人： Leslie Garry Adams , Richard P. Crawford , Donald S. Davis , Thomas A. Ficht , Roger Smith, III , Blair A. Sowa , Joe W. Templeton , John D. Williams , Albert M. Wu
CPC分类号： C07K14/23 , A61K39/00 , Y10S424/823 , Y10S435/822
摘要： The present invention is an improved vaccine against Brucella abortus which permits differentiation between vaccinated and field strain infected cattle. The vaccine can be administered in two different forms: (1) cell envelopes isolated from an O polysaccharide antigen deficient, stable transposon mutant of B. abortus or (2) an O polysaccharide antigen deficient, stable transposon mutant of B. abortus.
摘要翻译： 本发明是针对流产布鲁杆菌的改良疫苗，其允许在接种疫苗和野外菌株感染的牛之间进行分化。 疫苗可以以两种不同的形式施用：（1）从流产流产的O多糖抗原缺陷型，稳定转座子突变体分离的细胞包膜或（2）流产流产的O多糖抗原缺陷型稳定转座子突变体。
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公开(公告)号：US5348857A
公开(公告)日：1994-09-20
申请号：US972791
申请日：1992-11-06
申请人： Thomas A. Ficht , L. Garry Adams
发明人： Thomas A. Ficht , L. Garry Adams
CPC分类号： C12Q1/689 , Y10S436/811
摘要： A method for detecting Brucella infection in an animal which is reliable, rapid, and able to identify species and biovars of Brucella. The detection method includes the amplification of the omp2 gene locus of Brucella and analysis of restriction digestion fragments specific to Brucella and to individual species and groups of biovars of Brucella.
摘要翻译： 一种用于检测动物中布鲁杆菌感染的方法，其可靠，快速，能够鉴定布鲁杆菌的物种和生物物种。 检测方法包括扩增布鲁杆菌的_o2基因位点，分析Brucella特异性的限制性消化片段以及Brucella的单个物种和生物群组。
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4.发明授权Controlled release vaccines and methods for treating Brucella diseases and disorders 有权控制释放疫苗和治疗布鲁杆菌疾病和障碍的方法公开(公告)号：US09248176B2
公开(公告)日：2016-02-02
申请号：US13269382
申请日：2011-10-07
CPC分类号： A61K39/098 , A61K2039/522 , A61K2039/54 , A61K2039/541 , A61K2039/622 , G01N33/56911 , G01N2333/23 , G01N2469/20 , G01N2800/52
摘要： Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to vaccines. In additional embodiments, the invention relates to formulations capable of releasing said vaccines at a controlled rate of release in vivo. In further embodiments, the invention relates to modified strains of the bacteria Brucella melitensis and Brucella abortus. In still further embodiments, the invention relates to compositions that do not induce clinical symptoms or splenomegaly in a subject receiving said compositions.
摘要翻译： 本文公开了用于治疗布鲁杆菌诱导的疾病和病症的方法和组合物。 在优选的实施方案中，本发明涉及疫苗。 在另外的实施方案中，本发明涉及能够以受控的体内释放速率释放所述疫苗的制剂。 在进一步的实施方案中，本发明涉及细菌布鲁氏菌（Brucella melitensis）和流产布鲁杆菌（Brucella abortus）的修饰菌株。 在另外的实施方案中，本发明涉及在接受所述组合物的受试者中不诱导临床症状或脾肿大的组合物。
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5.发明申请CONTROLLED RELEASE VACCINES AND METHODS FOR TREATING BRUCELLA DISEASES AND DISORDERS 有权控制释放疫苗和治疗布鲁塞尔疾病和疾病的方法公开(公告)号：US20140248354A1
公开(公告)日：2014-09-04
申请号：US13269382
申请日：2011-10-07
CPC分类号： A61K39/098 , A61K2039/522 , A61K2039/54 , A61K2039/541 , A61K2039/622 , G01N33/56911 , G01N2333/23 , G01N2469/20 , G01N2800/52
摘要： Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to vaccines. In additional embodiments, the invention relates to formulations capable of releasing said vaccines at a controlled rate of release in vivo. In further embodiments, the invention relates to modified strains of the bacteria Brucella melitensis and Brucella abortus. In still further embodiments, the invention relates to compositions that do not induce clinical symptoms or splenomegaly in a subject receiving said compositions.
摘要翻译： 本文公开了用于治疗布鲁杆菌诱导的疾病和病症的方法和组合物。 在优选的实施方案中，本发明涉及疫苗。 在另外的实施方案中，本发明涉及能够以受控的体内释放速率释放所述疫苗的制剂。 在进一步的实施方案中，本发明涉及细菌布鲁氏菌（Brucella melitensis）和流产布鲁杆菌（Brucella abortus）的修饰菌株。 在另外的实施方案中，本发明涉及在接受所述组合物的受试者中不诱导临床症状或脾肿大的组合物。
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