公开(公告)号：US20110096893A1

公开(公告)日：2011-04-28

申请号：US12911335

申请日：2010-10-25

申请人： Thomas Allmendinger ,  Steffen Kappler

发明人： Thomas Allmendinger ,  Steffen Kappler

IPC分类号： A61B6/03 ,  G06F19/00 ,  G06F17/18

CPC分类号： A61B6/032 ,  A61B5/0452 ,  A61B6/503

摘要： A method and a CT system are disclosed for predicting specific cardiac cycle phases within the scope of a CT examination, wherein signal profiles of the heart are continuously recorded during the examination over a plurality of cardiac cycles, wherein times of successive cycle positions with the same characteristics are determined with the aid of the signal profiles and the successive cycle lengths of the cardiac cycles are determined with the aid of the determined times, wherein typical patterns in successive cycle lengths over a first number of past and successive cardiac cycles are sought after and a current or future cycle length is determined by recording cycle patterns in a second, smaller number of cycle lengths including their typical successive cycle length within the first number of current past cycle lengths, and predicting, using probabilistic methods, the cycle length that follows the last determined cycle pattern on the basis of the cycle patterns currently determined during the CT examination.

摘要翻译： 公开了一种用于预测CT检查范围内的特定心脏周期相位的方法和CT系统，其中心脏的信号分布在检查期间在多个心动周期中连续记录，其中相同周期位置的时间相同 借助于确定的时间来确定心律周期的连续循环长度，其中在第一数量的过去和连续的心动周期之后寻求连续循环长度中的典型模式，并且 通过以第二较小数量的循环长度记录循环模式来确定当前或将来循环长度，包括其在当前过去循环长度的第一数量内的典型连续循环长度，以及使用概率方法预测随后的周期长度 根据当前确定的周期模式，最后确定的周期模式 进行CT检查。

公开(公告)号：US08259898B2

公开(公告)日：2012-09-04

申请号：US12911335

申请日：2010-10-25

申请人： Thomas Allmendinger ,  Steffen Kappler

发明人： Thomas Allmendinger ,  Steffen Kappler

IPC分类号： A61B6/00

CPC分类号： A61B6/032 ,  A61B5/0452 ,  A61B6/503

摘要： A method and a CT system are disclosed for predicting specific cardiac cycle phases within the scope of a CT examination, wherein signal profiles of the heart are continuously recorded during the examination over a plurality of cardiac cycles, wherein times of successive cycle positions with the same characteristics are determined with the aid of the signal profiles and the successive cycle lengths of the cardiac cycles are determined with the aid of the determined times, wherein typical patterns in successive cycle lengths over a first number of past and successive cardiac cycles are sought after and a current or future cycle length is determined by recording cycle patterns in a second, smaller number of cycle lengths including their typical successive cycle length within the first number of current past cycle lengths, and predicting, using probabilistic methods, the cycle length that follows the last determined cycle pattern on the basis of the cycle patterns currently determined during the CT examination.

摘要翻译： 公开了一种用于预测CT检查范围内的特定心脏周期相位的方法和CT系统，其中心脏的信号分布在检查期间在多个心动周期中连续记录，其中相同周期位置的时间相同 借助于确定的时间来确定心律周期的连续循环长度，其中在第一数量的过去和连续的心动周期之后寻求连续循环长度中的典型模式，并且 通过以第二较小数量的循环长度记录循环模式来确定当前或将来循环长度，包括其在当前过去循环长度的第一数量内的典型连续循环长度，以及使用概率方法预测随后的周期长度 根据当前确定的周期模式，最后确定的周期模式 进行CT检查。

公开(公告)号：US20120022127A1

公开(公告)日：2012-01-26

申请号：US13260952

申请日：2010-04-07

申请人： Thomas Allmendinger

发明人： Thomas Allmendinger

IPC分类号： A61K31/40 ,  A61P1/04 ,  C07D207/12

CPC分类号： C07D207/12 ,  A61K9/0075 ,  A61K31/40 ,  C07D233/60

摘要： A two step process for preparing a compound of formula I in salt or zwitterionic form, wherein R1 and R2 are each independently C3-C8-cycloalkyl or C6-C10-aryl; and R3 and R4 are each independently C1-C8-alkyl. The process minimizes variation in the relative proportions of diastereoisomers.

摘要翻译： 制备盐或两性离子形式的式I化合物的两步法，其中R 1和R 2各自独立地为C 3 -C 8 - 环烷基或C 6 -C 10 - 芳基; 并且R 3和R 4各自独立地为C 1 -C 8 - 烷基。 该方法使非对映异构体的相对比例的变化最小化。

公开(公告)号：US20100195889A1

公开(公告)日：2010-08-05

申请号：US12698187

申请日：2010-02-02

申请人： Thomas Allmendinger

发明人： Thomas Allmendinger

IPC分类号： G06K9/00

CPC分类号： A61B6/481 ,  A61B6/032 ,  A61B6/4014 ,  A61B6/482 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  G06T7/254 ,  G06T2207/10081 ,  G06T2207/30048

摘要： A method is disclosed for scanning a moving examination object using a CT-System, with which data is captured during a circular movement of a transmitter/receiver pair through 360 degrees about the examination object, the data being assigned to the respective angular position. The 360 degrees are divided into n subsegments of equal size, where n is greater than 2, an even number and not divisible by 4. In at least one embodiment, the data assigned to the odd number subsegments forms a first data record and the data assigned to the even number subsegments forms a second data record. Differential information is determined between the first data record and the second data record. Motion information relating to the movement of the examination object is determined using the differential information.

摘要翻译： 公开了一种用于使用CT系统扫描移动检查对象的方法，在发送器/接收器对围绕检查对象360度的圆周移动期间捕获数据，该数据被分配给相应的角位置。 360度被划分为相等大小的n个子段，其中n大于2，偶数，不能被4整除。在至少一个实施例中，分配给奇数子段的数据形成第一数据记录和数据 分配给偶数子段形成第二个数据记录。 在第一数据记录和第二数据记录之间确定差分信息。 使用差分信息确定与检查对象的移动有关的运动信息。

公开(公告)号：US20050234126A1

公开(公告)日：2005-10-20

申请号：US10516054

申请日：2003-05-28

申请人： Thomas Allmendinger ,  Peter Furter

发明人： Thomas Allmendinger ,  Peter Furter

IPC分类号： A61K31/165 ,  A61K31/421 ,  A61K45/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P25/22 ,  A61P25/28 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C237/22 ,  C07D263/20 ,  C07D263/24 ,  A61K31/277

CPC分类号： C07D263/20 ,  C07C237/22 ,  C07D263/24

摘要： The present inventions relates to a novel compound of formula (I) or a pharmaceutically acceptable salt thereof, the use and manufacture of a compound of formula (I) or a pharmaceutical composition comprising a compound of formula (I).

摘要翻译： 本发明涉及式（I）的新化合物或其药学上可接受的盐，式（I）化合物或包含式（I）化合物的药物组合物的用途和制备。

公开(公告)号：US08897525B2

公开(公告)日：2014-11-25

申请号：US13069438

申请日：2011-03-23

申请人： Thomas Allmendinger ,  Bernhard Schmidt

发明人： Thomas Allmendinger ,  Bernhard Schmidt

IPC分类号： G06K9/00 ,  G06T5/50 ,  G06T11/00 ,  G06T5/00 ,  A61B6/00

CPC分类号： A61B6/503 ,  A61B6/507 ,  A61B6/5264 ,  G06T5/003 ,  G06T5/50 ,  G06T11/005 ,  G06T2207/10081 ,  G06T2207/30004 ,  G06T2211/412

摘要： A method for reconstructing picture data of a cyclically-moving object from measurement data is disclosed, with the measurement data being detected beforehand for a relative rotational movement between a radiation source of a computed tomography system and the object under examination during a plurality of movement cycles of the object under examination. In at least one embodiment, a first picture and a second picture are determined from the measurement data, with measurement data of different movement cycles being combined for reconstruction of the second picture into a measurement dataset to be used as the basis for the picture reconstruction. Difference information is computed by comparing the first picture with the second picture. Using the difference information, a result picture is computed from the first picture and the second picture.

摘要翻译： 公开了一种用于从测量数据重建循环移动物体的图像数据的方法，其中预先检测测量数据以在多个移动循环期间在计算机断层摄影系统的辐射源与被检查物体之间的相对旋转运动 的被检查对象。 在至少一个实施例中，从测量数据确定第一图像和第二图像，将不同移动周期的测量数据组合以将第二图像重建为要用作图像重建的基础的测量数据集。 差分信息通过将第一图像与第二图像进行比较来计算。 使用差分信息，从第一图像和第二图像计算结果图像。

公开(公告)号：US08737701B2

公开(公告)日：2014-05-27

申请号：US12785528

申请日：2010-05-24

申请人： Thomas Allmendinger

发明人： Thomas Allmendinger

IPC分类号： G06K9/00

CPC分类号： A61B6/504 ,  A61B5/0402 ,  A61B6/032 ,  A61B6/4014 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/482 ,  A61B6/507 ,  G06T11/005 ,  G06T2211/412

摘要： A method is disclosed for reconstructing image data of a moving examination object from measured data, the measured data having been acquired during a rotating movement of a radiation source of a computed tomography system around the examination object. In at least one embodiment, first image data are determined from the measured data. Movement information is determined from the first image data by forming the difference between images. Time instants of little movement of the examination object are determined from the movement information, the determined time instants being dependent on the location or site within the examination object. Finally, second image data are reconstructed taking the determined time instants into account. These data can be output as result images.

摘要翻译： 公开了一种用于从测量数据重建运动检查对象的图像数据的方法，所测量的数据已经在计算机断层摄影系统的辐射源围绕检查对象的旋转运动期间获取。 在至少一个实施例中，从测量数据确定第一图像数据。 通过形成图像之间的差异，从第一图像数据确定运动信息。 从移动信息确定检查对象的小移动的时刻，确定的时刻依赖于检查对象内的位置或位置。 最后，考虑确定的时刻来重构第二图像数据。 这些数据可以作为结果图像输出。

公开(公告)号：US08611987B2

公开(公告)日：2013-12-17

申请号：US12818587

申请日：2010-06-18

申请人： Thomas Allmendinger ,  Heiko Mehldau ,  Thomas Seiler ,  Carsten Thierfelder

发明人： Thomas Allmendinger ,  Heiko Mehldau ,  Thomas Seiler ,  Carsten Thierfelder

IPC分类号： A61B5/05

CPC分类号： A61B5/0456 ,  A61B6/503 ,  A61B6/541

摘要： A method is disclosed for assisting in determination of the suitability of a patient for a scan of the heart of the patient using an X-ray computer tomograph. In at least one embodiment of the method, a) an electrocardiogram of the patient is recorded; b) the electrocardiogram is evaluated by predicting the occurrence time of at least the immediately following R wave on the basis of at least four immediately consecutive R waves of the electrocardiogram which were measured last, and comparing this with the actual measured occurrence time of the next R wave; and c) wherein the quality of the prediction is visualized qualitatively. Further, in at least one embodiment, a device is disclosed including an ECG instrument and a computation device for carrying out the method. At least one embodiment of the invention furthermore relates to a method and a device for scanning the heart of a patient on the basis of a prediction of R waves.

摘要翻译： 公开了一种用于帮助确定患者对于使用X射线计算机断层摄影术对患者心脏进行扫描的适合性的方法。 在该方法的至少一个实施例中，a）记录患者的心电图; b）通过基于最后测量的至少四个紧邻的心电图的R波来预测至少紧随其后的R波的发生时间来评估心电图，并将其与下一次的实际测量的发生时间进行比较 R波; 和c）其中预测的质量被定性可视化。 此外，在至少一个实施例中，公开了一种包括用于执行该方法的ECG仪器和计算装置的装置。 本发明的至少一个实施例还涉及一种用于基于R波的预测来扫描患者的心脏的方法和装置。

公开(公告)号：US08290117B2

公开(公告)日：2012-10-16

申请号：US12698187

申请日：2010-02-02

申请人： Thomas Allmendinger

发明人： Thomas Allmendinger

IPC分类号： A61B6/03

CPC分类号： A61B6/481 ,  A61B6/032 ,  A61B6/4014 ,  A61B6/482 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  G06T7/254 ,  G06T2207/10081 ,  G06T2207/30048

摘要： A method is disclosed for scanning a moving examination object using a CT-System, with which data is captured during a circular movement of a transmitter/receiver pair through 360 degrees about the examination object, the data being assigned to the respective angular position. The 360 degrees are divided into n subsegments of equal size, where n is greater than 2, an even number and not divisible by 4. In at least one embodiment, the data assigned to the odd number subsegments forms a first data record and the data assigned to the even number subsegments forms a second data record. Differential information is determined between the first data record and the second data record. Motion information relating to the movement of the examination object is determined using the differential information.

摘要翻译： 公开了一种用于使用CT系统扫描移动检查对象的方法，在发送器/接收器对围绕检查对象360度的圆周移动期间捕获数据，该数据被分配给相应的角位置。 360度被划分为相等大小的n个子段，其中n大于2，偶数，不能被4整除。在至少一个实施例中，分配给奇数子段的数据形成第一数据记录和数据 分配给偶数子段形成第二个数据记录。 在第一数据记录和第二数据记录之间确定差分信息。 使用差分信息确定与检查对象的移动有关的运动信息。

公开(公告)号：US20090088479A1

公开(公告)日：2009-04-02

申请号：US12293162

申请日：2007-03-19

申请人： Thomas Allmendinger ,  Frank Stowasser

发明人： Thomas Allmendinger ,  Frank Stowasser

IPC分类号： A61K31/165 ,  C07C237/20

CPC分类号： C07C237/22

摘要： The invention relates to a new salt of aliskiren, the respective production and usage, and pharmaceutical preparations containing such a salt.

摘要翻译： 本发明涉及阿利吉仑的新盐，各自的生产和使用，以及含有这种盐的药物制剂。