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1.发明授权Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators 有权作为丙二酰辅酶A脱羧酶抑制剂的唑类可用作代谢调节剂公开(公告)号：US08110686B2
公开(公告)日：2012-02-07
申请号：US12772552
申请日：2010-05-03
申请人： Thomas Arrhenius , Jie Fei Cheng , Mark E. Wilson , Rossy Serafimov , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck
发明人： Thomas Arrhenius , Jie Fei Cheng , Mark E. Wilson , Rossy Serafimov , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck
IPC分类号： C07D513/02 , C07D513/00 , C07D417/00 , C07D277/00 , C07D277/62 , A61K31/44 , A61K31/425
CPC分类号： C07D277/70 , A61K31/4745 , A61K31/519 , A61K31/538 , A61K31/548 , A61K31/55 , C07D417/04 , C07D513/04
摘要： The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
摘要翻译： 本发明涉及治疗某些代谢疾病的方法，以及新化合物及其前药，和/或药学上可接受的盐，含有用于治疗这些疾病的化合物的药物组合物。 特别地，本发明涉及通过抑制丙二酰辅酶A脱羧酶（MCD）来治疗心血管疾病，糖尿病，癌症，酸中毒和肥胖症的新型化合物和组合物的用途。 这些化合物具有式（I）和（II），其中Y，C，R 1，R 2，R 6和R 7在本文中定义。
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2.发明申请Azoles as Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators 有权Azoles作为可用作代谢调节剂的丙二酰辅酶A脱羧酶抑制剂公开(公告)号：US20110028514A1
公开(公告)日：2011-02-03
申请号：US12772552
申请日：2010-05-03
申请人： Thomas Arrhenius , Jie Fei Cheng , Mark E. Wilson , Rossy Serafimov , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck
发明人： Thomas Arrhenius , Jie Fei Cheng , Mark E. Wilson , Rossy Serafimov , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck
IPC分类号： A61K31/437 , C07D513/04 , A61P3/00 , A61P9/00 , A61P3/04 , A61P3/10 , A61P35/00
CPC分类号： C07D277/70 , A61K31/4745 , A61K31/519 , A61K31/538 , A61K31/548 , A61K31/55 , C07D417/04 , C07D513/04
摘要： The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
摘要翻译： 本发明涉及治疗某些代谢疾病的方法，以及新化合物及其前药，和/或药学上可接受的盐，含有用于治疗这些疾病的化合物的药物组合物。 特别地，本发明涉及通过抑制丙二酰辅酶A脱羧酶（MCD）来治疗心血管疾病，糖尿病，癌症，酸中毒和肥胖症的新型化合物和组合物的用途。 这些化合物具有式（I）和（II），其中Y，C，R 1，R 2，R 6和R 7在本文中定义。
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3.发明授权Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors 有权用作丙二酰辅酶A脱羧酶抑制剂的基于氰基胍的唑类化合物公开(公告)号：US07786145B2
公开(公告)日：2010-08-31
申请号：US10900706
申请日：2004-07-28
申请人： Jie Fei Cheng , Bin Liu , Thomas Arrhenius , Mark E. Wilson , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
发明人： Jie Fei Cheng , Bin Liu , Thomas Arrhenius , Mark E. Wilson , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
IPC分类号： A61K31/4406 , A61K31/428 , A61K31/4025 , C07D417/12 , C07D277/72 , C07D207/14
CPC分类号： C07D277/70 , A61K31/428 , A61K31/4439 , A61K31/4745 , A61K31/506 , C07D417/12
摘要： The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。
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4.发明授权Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators 失效作为丙二酰辅酶A脱羧酶抑制剂的唑类可用作代谢调节剂公开(公告)号：US07709510B2
公开(公告)日：2010-05-04
申请号：US10468379
申请日：2002-02-19
申请人： Thomas Arrhenius , Jie Fei Cheng , Mark E. Wilson , Rossy Serafimov , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck
发明人： Thomas Arrhenius , Jie Fei Cheng , Mark E. Wilson , Rossy Serafimov , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck
IPC分类号： A61K31/425 , C07D277/00 , C07D277/62
CPC分类号： C07D277/70 , A61K31/4745 , A61K31/519 , A61K31/538 , A61K31/548 , A61K31/55 , C07D417/04 , C07D513/04
摘要： The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
摘要翻译： 本发明涉及治疗某些代谢疾病的方法，以及新化合物及其前药，和/或药学上可接受的盐，含有用于治疗这些疾病的化合物的药物组合物。 特别地，本发明涉及通过抑制丙二酰辅酶A脱羧酶（MCD）来治疗心血管疾病，糖尿病，癌症，酸中毒和肥胖症的新型化合物和组合物的用途。 这些化合物具有式（I）和（II），其中Y，C，R 1，R 2，R 6和R 7在本文中定义。
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5.发明申请公开(公告)号：US20090124660A1
公开(公告)日：2009-05-14
申请号：US12245558
申请日：2008-10-03
申请人： Jie Fei Cheng , Mi Chen , Thomas Arrhenius , Mark E. Wilson , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
发明人： Jie Fei Cheng , Mi Chen , Thomas Arrhenius , Mark E. Wilson , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
IPC分类号： A61K31/454 , C07D417/12
CPC分类号： C07D417/12 , A61K31/454 , A61K31/4545 , A61K31/55
摘要： The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。
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6.发明授权Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases 有权唑类化合物作为用于治疗代谢疾病的丙二酰辅酶A脱羧酶抑制剂公开(公告)号：US07723366B2
公开(公告)日：2010-05-25
申请号：US10468378
申请日：2002-02-19
申请人： Thomas Arrhenius , Jie Fei Cheng , Mark E. Wilson , Rossy Serafimov , Masahiro Nishimoto , David Mark Wallace , Sovouthy Tith , Steve Joel Brown , Charles Stanford Harmon , Gary D. Lopaschuk , Jason R. Dyck
发明人： Thomas Arrhenius , Jie Fei Cheng , Mark E. Wilson , Rossy Serafimov , Masahiro Nishimoto , David Mark Wallace , Sovouthy Tith , Steve Joel Brown , Charles Stanford Harmon , Gary D. Lopaschuk , Jason R. Dyck
IPC分类号： A61K31/425 , A61K31/445 , A61K31/44 , C07D277/72 , C07D277/00
CPC分类号： A61K31/423 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541
摘要： The present invention relates to methods of treatment of certain metabolic diseases, and to the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, the invention relates to the use of compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the following formulae: (I) and (II) Wherein Y, C, R1, R2, R6, and R7 are defined herein.
摘要翻译： 本发明涉及治疗某些代谢疾病的方法，以及使用化合物及其前药，和/或药学上可接受的盐，含有可用于治疗这些疾病的化合物的药物组合物。 特别地，本发明涉及通过抑制丙二酰辅酶A脱羧酶（MCD）来治疗心血管疾病，糖尿病，癌症，酸中毒和肥胖的化合物和组合物的用途。 这些化合物具有下式：（I）和（II）其中Y，C，R 1，R 2，R 6和R 7在本文中定义。
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7.发明授权公开(公告)号：US08080665B2
公开(公告)日：2011-12-20
申请号：US12245558
申请日：2008-10-03
申请人： Jie Fei Cheng , Mi Chen , Thomas Arrhenius , Mark E. Wilson , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
发明人： Jie Fei Cheng , Mi Chen , Thomas Arrhenius , Mark E. Wilson , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
IPC分类号： A61K31/4468 , C07D211/58
CPC分类号： C07D417/12 , A61K31/454 , A61K31/4545 , A61K31/55
摘要： The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。
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8.发明授权公开(公告)号：US07449482B2
公开(公告)日：2008-11-11
申请号：US10900705
申请日：2004-07-28
申请人： Jie Fei Cheng , Mi Chen , Thomas Arrhenius , Mark E. Wilson , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
发明人： Jie Fei Cheng , Mi Chen , Thomas Arrhenius , Mark E. Wilson , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
IPC分类号： A61K31/4468
CPC分类号： C07D417/12 , A61K31/454 , A61K31/4545 , A61K31/55
摘要： The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。
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9.发明授权公开(公告)号：US07897615B2
公开(公告)日：2011-03-01
申请号：US11866266
申请日：2007-10-02
IPC分类号： A61K31/44 , A61K31/41 , A61K31/425 , A61K31/42
CPC分类号： C07D277/70 , C07D417/12
摘要： The present invention provides previous methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。
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10.发明申请公开(公告)号：US20080161358A1
公开(公告)日：2008-07-03
申请号：US11866266
申请日：2007-10-02
IPC分类号： A61K31/428 , C07D277/72 , C07D417/02 , A61P9/00 , A61P3/04 , A61P35/00 , A61P3/10 , A61P3/00 , A61K31/4439
CPC分类号： C07D277/70 , C07D417/12
摘要： The present invention provides previous methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。
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