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19 条记录 (耗时 0.041 秒)

    N-alkylated carboxylic acid derivatives as anti-convulsant agents
    7.
    发明授权
    N-alkylated carboxylic acid derivatives as anti-convulsant agents 失效
    N-烷基化羧酸衍生物作为抗惊厥剂

    公开(公告)号：US4432985A

    公开(公告)日：1984-02-21

    申请号：US358167

    申请日：1982-03-15

    申请人： Alex M. Nadzan ,  George R. Granneman

    发明人： Alex M. Nadzan ,  George R. Granneman

    IPC分类号： A61K31/17 ,  A61K31/195 ,  C07D295/15 ,  C07D295/215 ,  A61K31/445 ,  C07D211/14

    CPC分类号： C07D295/215 ,  A61K31/17 ,  A61K31/195 ,  C07D295/15

    摘要： Described are compounds of the formula ##STR1## wherein R is hydrogen or loweralkyl; R.sub.1 is --OR.sub.2 or --NR.sub.2 R.sub.3 wherein R.sub.2 and R.sub.3 independently of one another denote hydrogen or loweralkyl; n is 0 or 1; R.sub.4 and R.sub.5 independently of one another denote loweralkyl or together form a 5 or 6 membered cycloalkyl substituted by hydrogen or loweralkyl, and together with the nitrogen atom, form a ring; and pharmaceutically acceptable salts thereof and their use as anticonvulsant agents in a method of controlling convulsions or seizures.

    摘要翻译： 描述了下式的化合物：其中R是氢或低级烷基; R 1是-OR 2或-NR 2 R 3，其中R 2和R 3彼此独立地表示氢或低级烷基; n为0或1; R4和R5彼此独立地表示低级烷基或一起形成被氢或低级烷基取代的5或6元环烷基，并与氮原子一起形成环; 及其药学上可接受的盐及其在控制惊厥或惊厥的方法中作为抗惊厥剂的用途。

    Derivatives of D-glutamic acid and D-aspartic acid
    10.
    发明授权
    Derivatives of D-glutamic acid and D-aspartic acid 失效
    D-谷氨酸和D-天冬氨酸的衍生物

    公开(公告)号：US5128346A

    公开(公告)日：1992-07-07

    申请号：US571945

    申请日：1990-08-23

    申请人： Alex M. Nadzan ,  James F. Kerwin ,  Chun W. Lin

    发明人： Alex M. Nadzan ,  James F. Kerwin ,  Chun W. Lin

    IPC分类号： C07C271/22 ,  C07C275/28 ,  C07D209/42 ,  C07D213/56 ,  C07D215/48 ,  C07D241/44 ,  C07D401/12 ,  C07K5/072

    CPC分类号： C07D401/12 ,  C07C271/22 ,  C07C275/28 ,  C07D209/42 ,  C07D213/56 ,  C07D215/48 ,  C07D241/44 ,  C07K5/06104

    摘要： A compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are substituents; R.sub.6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is a bond, an alkylene group, an alkenylene group, an alkadienylene group or a heteroatom containing linking group; D is a substituted acyl group or tetrazolyl; Z is CO, C(S) or S(O).sub.2 ; Ar is a heterocyclic group; and n is 1 to 3.Also disclosed are a composition and a method for antagonizing CCK, a composition and method for treating or preventing gastrointestinal, central nervous, appetite regulating and pain regulating systems, a composition and method for treating or preventing hyperinsulinemia, methods of making the compounds and intermediates useful in making the compounds.

    摘要翻译： 下式的化合物：其中R1和R2是取代基; R6是氢，低级烷基，环烷基，低级烯基，芳基烷基，（取代的芳基）烷基或（杂环）烷基; B是键，亚烷基，亚烯基，亚二烯基或含杂原子的连接基团; D是取代的酰基或四唑基; Z是CO，C（S）或S（O）2; Ar是杂环基; 还公开了拮抗CCK的组合物和方法，治疗或预防胃肠，中枢神经，食欲调节和疼痛调节系统的组合物和方法，治疗或预防高胰岛素血症的组合物和方法，方法 使得化合物和中间体可用于制备化合物。