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公开(公告)号：US06500645B1
公开(公告)日：2002-12-31
申请号：US09324217
申请日：1999-06-02
申请人： Thomas Børglum Kjeldsen , Per Balschmidt , Annette Frost Pettersson , Knud Vad , Jakob Brandt , Svend Havelund
发明人： Thomas Børglum Kjeldsen , Per Balschmidt , Annette Frost Pettersson , Knud Vad , Jakob Brandt , Svend Havelund
IPC分类号： C12P2106
CPC分类号： C07K14/62 , C07K14/00 , C07K14/605 , C07K2319/00 , C07K2319/02 , C07K2319/75 , C12N15/62 , C12N15/625 , C12N15/67 , C12N15/81 , C12N15/815
摘要： The present invention relates to polypeptides expressed and processed in yeast, a DNA construct comprising a DNA sequence encoding such polypeptides, vectors carrying such DNA fragments and yeast cells transformed with the vectors, as well as a process of producing heterologous proteins in yeast.
摘要翻译： 本发明涉及在酵母中表达和加工的多肽，包含编码这种多肽的DNA序列的DNA构建体，携带该DNA片段的载体和用载体转化的酵母细胞，以及在酵母中产生异源蛋白质的方法。
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公开(公告)号：US20110021423A1
公开(公告)日：2011-01-27
申请号：US12673226
申请日：2008-08-12
摘要： The invention is related to fast acting insulin analogues which can form soluble mix-tures (pre-mixed or self-mixed) with long acting insulin analogues. The fast action is achieved through monomerizing substitutions/deletions in the C-terminus of the B-chain of human insulin and the mixability with long acting insulin analogues is achieved through a substitution of the Zn-binding His in position B10 of human insulin with a Gln amino acid residue. In one embodiment the invention is related to fast acting insulin analogues in which at least one of the natural amino acid residues in position B22-B30 in the human B-chain has been substituted with another amino acid residue having the effect of promoting formation of the monomeric form of insulin, the His amino acid residue in position 10 in the B-chain is substituted with a Gln and wherein further one or more of the amino acid residues in position B22-B30 optionally have been deleted.
摘要翻译： 本发明涉及可与长效胰岛素类似物形成可溶性混合物（预混合或自混合）的快速作用胰岛素类似物。 快速作用通过在人胰岛素的B链的C末端进行单体取代/缺失实现，并且通过用人胰岛素B10位置上的Zn结合His取代长效胰岛素类似物的混合性来实现 Gln氨基酸残基。 在一个实施方案中，本发明涉及快速作用的胰岛素类似物，其中人B链中位置B22-B30中的至少一个天然氨基酸残基已经被另一个氨基酸残基取代，其具有促进形成 单体形式的胰岛素，B链中10位的His氨基酸残基被Gln取代，并且其中位置B22-B30中的一个或多个氨基酸残基任选地被缺失。
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公开(公告)号：US08575096B2
公开(公告)日：2013-11-05
申请号：US12673226
申请日：2008-08-12
IPC分类号： C07K14/62
摘要： The invention is related to fast acting insulin analogues which can form soluble mix-tures (pre-mixed or self-mixed) with long acting insulin analogues. The fast action is achieved through monomerizing substitutions/deletions in the C-terminus of the B-chain of human insulin and the mixability with long acting insulin analogues is achieved through a substitution of the Zn-binding His in position B10 of human insulin with a Gln amino acid residue. In one embodiment the invention is related to fast acting insulin analogues in which at least one of the natural amino acid residues in position B22-B30 in the human B-chain has been substituted with another amino acid residue having the effect of promoting formation of the monomeric form of insulin, the His amino acid residue in position 10 in the B-chain is substituted with a Gln and wherein further one or more of the amino acid residues in position B22-B30 optionally have been deleted.
摘要翻译： 本发明涉及可与长效胰岛素类似物形成可溶性混合物（预混合或自混合）的快速作用胰岛素类似物。 快速作用通过在人胰岛素的B链的C末端进行单体取代/缺失实现，并且通过用人胰岛素B10位置上的Zn结合His取代长效胰岛素类似物的混合性来实现 Gln氨基酸残基。 在一个实施方案中，本发明涉及快速作用的胰岛素类似物，其中人B链中位置B22-B30中的至少一个天然氨基酸残基已经被另一个氨基酸残基取代，其具有促进形成 单体形式的胰岛素，B链中10位的His氨基酸残基被Gln取代，并且其中位置B22-B30中的一个或多个氨基酸残基任选地被缺失。
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公开(公告)号：US06214547B1
公开(公告)日：2001-04-10
申请号：US09012669
申请日：1998-01-23
IPC分类号： C12Q168
CPC分类号： C12N15/815 , C07K14/00 , C07K14/62 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N15/62 , C12N15/625 , C12N15/81
摘要： The present invention relates to synthetic leader peptide sequences for secreting polypeptides in yeast.
摘要翻译： 本发明涉及用于在酵母中分泌多肽的合成前导肽序列。
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5.发明授权Glucose dependent release of insulin from glucose sensing insulin derivatives 有权从葡萄糖感测胰岛素衍生物中葡萄糖依赖性释放胰岛素公开(公告)号：US07316999B2
公开(公告)日：2008-01-08
申请号：US09870884
申请日：2001-05-31
申请人： Thomas Hoeg-Jensen , Svend Havelund , Jan Markussen , Soren Ostergaard , Signe Ridderberg , Per Balschmidt , Lauge Schaffer , Ib Jonassen
发明人： Thomas Hoeg-Jensen , Svend Havelund , Jan Markussen , Soren Ostergaard , Signe Ridderberg , Per Balschmidt , Lauge Schaffer , Ib Jonassen
CPC分类号： C07K14/62
摘要： Insulin derivatives having a built-in glucose sensor, capable of delivering insulin from a depot as a function of the glucose concentration in the surrounding medium (e.g. tissue), such that the rate of insulin release from the depot increases with an increased glucose concentration and decreases with a decreased glucose concentration.
摘要翻译： 具有内置葡萄糖传感器的胰岛素衍生物，其能够将来自贮库的胰岛素作为周围介质（例如组织）中的葡萄糖浓度的函数，使得从贮库中释放的胰岛素的速率随着葡萄糖浓度的增加而增加，并且 葡萄糖浓度降低。
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公开(公告)号：US09018161B2
公开(公告)日：2015-04-28
申请号：US12442190
申请日：2007-09-20
申请人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Nørgaard , Svend Havelund
发明人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Nørgaard , Svend Havelund
摘要： The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
摘要翻译： 本发明涉及对蛋白酶表现出抗性的新型胰岛素类似物，其中至少两个氨基酸相对于母体胰岛素分子被取代和/或缺失。 还提供了制备这种胰岛素类似物的方法，含有本发明的胰岛素类似物的胰岛素制剂和使用这些胰岛素类似物治疗糖尿病的方法。
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公开(公告)号：US20100009898A1
公开(公告)日：2010-01-14
申请号：US12442190
申请日：2007-09-20
申请人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Norgaard , Svend Havelund
发明人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Norgaard , Svend Havelund
摘要： The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
摘要翻译： 本发明涉及对蛋白酶表现出抗性的新型胰岛素类似物，其中至少两个氨基酸相对于母体胰岛素分子被取代和/或缺失。 还提供了制备这种胰岛素类似物的方法，含有本发明的胰岛素类似物的胰岛素制剂和使用这些胰岛素类似物治疗糖尿病的方法。
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公开(公告)号：US20050222006A1
公开(公告)日：2005-10-06
申请号：US11131996
申请日：2005-05-18
CPC分类号： A61K9/0019 , A61K9/1688 , A61K38/28
摘要： The present invention relates to protracted acting, water-soluble aggregates of derivatives of human insulin, derivatives of human insulin capable of forming such aggregates, pharmaceutical compositions containing them, and to the use of such aggregates in the treatment of diabetes.
摘要翻译： 本发明涉及人胰岛素衍生物，能够形成这种聚集体的人胰岛素的衍生物的延长作用的水溶性聚集体，含有它们的药物组合物，以及这些聚集体在治疗糖尿病中的用途。
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公开(公告)号：US20100120660A1
公开(公告)日：2010-05-13
申请号：US12598147
申请日：2008-04-30
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/0095 , A61K9/1075 , A61K9/19 , A61K47/34
摘要： Highly concentrated insulin solutions and pharmaceutical compositions are described as are methods of their preparation and uses thereof.
摘要翻译： 高度浓缩的胰岛素溶液和药物组合物被描述为它们的制备方法和用途。
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公开(公告)号：US20140315797A1
公开(公告)日：2014-10-23
申请号：US13823952
申请日：2011-10-14
申请人： Peter Madsen , Per Balschmidt , Svend Havelund , Thomas Hoeg-Jensen , Thomas Boerglum Kjeldsen , Charlotte Harkjaer Fynbo
发明人： Peter Madsen , Per Balschmidt , Svend Havelund , Thomas Hoeg-Jensen , Thomas Boerglum Kjeldsen , Charlotte Harkjaer Fynbo
IPC分类号： C07K14/62
CPC分类号： C07K14/62
摘要： The invention is related to novel N-terminally modified insulin derivatives, pharmaceutical compositions comprising such and methods of making such.
摘要翻译： 本发明涉及新型N-末端修饰的胰岛素衍生物，包含其的药物组合物及其制备方法。
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