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16 条记录 (耗时 0.042 秒)

    Method of producing flowable R,S-thioctic acid, R,S-thioctic acid and its use
    6.
    发明授权
    Method of producing flowable R,S-thioctic acid, R,S-thioctic acid and its use 失效
    生产可流动的R，S-硫辛酸，R，S-硫辛酸及其用途的方法

    公开(公告)号：US5705192A

    公开(公告)日：1998-01-06

    申请号：US618790

    申请日：1996-03-20

    申请人： Horst Bethge ,  Kurt Klostermann ,  Roland Moller ,  Gerhard Sator

    发明人： Horst Bethge ,  Kurt Klostermann ,  Roland Moller ,  Gerhard Sator

    IPC分类号： C07D339/04 ,  A61K9/16 ,  A61K9/20 ,  A61K31/385 ,  A61K9/14

    CPC分类号： A61K9/1688 ,  A61K31/385

    摘要： 1. A method of producing flowable R,S-thioctic acid, R,S-thioctic acid and its use. 2.1. Known methods of preparing flowable thioctic acid which can be galenically further processed by pressing to highly-concentrated, solid presentations with active-substance contents of more than 200 mg pure substance require the mixing of the thioctic-acid forms of different origins and/or a spraying on of galenic adjuvants from aqueous solution and a subsequent grinding process in order to arrive at a pressable granulate. 2.2. As a result of the fact that thioctic acid of any origin is placed in the fluid bed of a device suited for producing a fluid bed and that a built-up granulate consisting of thioctic acid is obtained by spraying a solution of thioctic acid of any origin onto the matter placed in the fluid bed under simultaneous removal of the solvent, it is possible to make a thioctic-acid form available which does not adhere to the pressing tool or exhibit a tendency to form fissures on the tablet even when tablets with 600 mg or more active-substance content are prepared. The novel R,S-thioctic acid has a specific surface of >0.7 m.sup.2 /g and a number of mesopores with a diameter between 2 and 30 nm.

    摘要翻译： 1.生产可流动的R，S-硫辛酸，R，S-硫辛酸及其用途的方法。 2.1。 制备可流动的硫辛酸的已知方法，其可以通过压制具有超过200mg纯物质的活性物质含量的高浓度固体表现物进一步加工而进一步加工，需要混合不同来源的硫辛酸形式和/或 从水溶液中喷洒盖仑佐剂并随后进行研磨处理以得到可挤压颗粒。 2.2。 由于任何来源的硫辛酸被放置在适于生产流化床的装置的流化床中，并且由硫辛酸组成的积层颗粒通过喷洒任何起源的硫辛酸溶液而获得 在同时除去溶剂的情况下放置在流化床中的物质上，可以制备硫辛酸形式，其不粘附到压制工具上，或者表现出在片剂上形成裂缝的趋势，即使具有600mg 或更多的活性物质含量。 新型R，S-硫辛酸具有> 0.7m 2 / g的比表面积和直径在2和30nm之间的多个中孔。

    Pope roll winder having direct drive
    9.
    发明授权
    Pope roll winder having direct drive 失效
    教练辊卷绕机直接驱动

    公开(公告)号：US5261620A

    公开(公告)日：1993-11-16

    申请号：US837734

    申请日：1992-02-19

    申请人： Dieter Holzinger ,  Roland Moller ,  Karl Ruck

    发明人： Dieter Holzinger ,  Roland Moller ,  Karl Ruck

    IPC分类号： B65H19/22 ,  B65H18/16

    CPC分类号： B65H19/2261 ,  B65H2408/236 ,  B65H2515/12

    摘要： A winder for winding a running web of paper, foil or similar. A support drum of web width is provided, and a winding drum on which the web is wound to a roll. A pair of primary swivel levers each feature on one end a fork for receiving a winding drum bearing and is mounted with its other end in the region of the support roll axis in such a way that the winding drum, in swiveling from a first position above the support roll, will in the running direction of the web approach the support roll while moving around it, passing in the process a primary section until reaching a second position. The winding drum with the still unfinished paper roll is taken over by a pair of secondary swivel levers with an essentially horizontal guideway extending from the second position across a secondary section up to a third position. A contact device forces the winding drum onto the support roll, and a drive is coordinated with the winding drum. A slide features guideways for guidance of the drive as it passes through the primary section, and is connected with the primary levers in such a way that it also will perform their swivel movement. A connecting link guide adjusts the radial position of the slide according to the current paper roll diameter, and ensures the slide tracking according to the increase in paper roll diameter. A guide rod clutch is arranged between the drive and the winding drum.

    摘要翻译： 用于卷绕纸张，箔片或类似物的运行网络的卷绕机。 提供腹板宽度的支撑鼓，以及卷筒，卷筒卷绕在卷筒上。 一对主旋转杆各自在一端具有用于接收卷绕鼓轴承的叉，并且其另一端安装在支撑辊轴线的区域中，使得卷绕滚筒从上方的第一位置旋转 支撑辊将沿着卷筒的运动方向接近支撑辊，同时在其周围移动，在该过程中通过主要部分直到达到第二位置。 具有仍未完成的卷筒纸的卷绕筒被一对辅助旋转杆带走，该第二旋转杆具有从第二位置穿过次级部分延伸到第三位置的基本上水平的导轨。 接触装置将卷绕鼓施加到支撑辊上，并且驱动器与卷绕鼓配合。 滑块具有用于在驱动器穿过主要部分时引导的导轨，并且与主杆连接，使得其也将执行其旋转运动。 连接导轨根据当前纸卷直径调整滑块的径向位置，并根据纸卷直径的增加确保滑块跟踪。 导杆离合器布置在驱动器和卷绕鼓之间。

    Method for Producing Amino- or Hydroxybenzonitriles
    10.
    发明申请
    Method for Producing Amino- or Hydroxybenzonitriles 有权
    生产氨基或羟基苯腈的方法

    公开(公告)号：US20070265462A1

    公开(公告)日：2007-11-15

    申请号：US11791579

    申请日：2005-11-29

    申请人： Roland Moller ,  Mario Gomez ,  Klaus Einmayr ,  Jens Hildebrad ,  Hans-Georg Erben ,  Hans-Peter Krimmer

    发明人： Roland Moller ,  Mario Gomez ,  Klaus Einmayr ,  Jens Hildebrad ,  Hans-Georg Erben ,  Hans-Peter Krimmer

    IPC分类号： C07C253/00

    CPC分类号： C07C253/22 ,  C07C253/34 ,  Y02P20/127 ,  C07C255/53

    摘要： What is claimed is a process for preparing amino- or hydroxybenzonitriles, in which, in the course of an ammonolysis, the corresponding amino- or hydroxybenzoic acid compounds are reacted with ammonia in the presence of a supported catalyst comprising phosphate at temperatures between 250° C. and 500° C. The actual preparation step is performed in a reaction gas (mixture) and without involvement of an organic solvent, and is followed by an at least 2-stage purification step. In this purification step, the gaseous mixture obtained from the preparation step is first converted to an aqueous basic suspension and then the product present in the solid is released from this suspension. The main advantage of this combination process is that the starting materials are not esters, which is why the resulting products, in contrast to the processes which are otherwise customary, are free of the by-products which are otherwise customary, which leads to a high product purity. The process claimed can additionally be performed in an extremely economically viable manner, since the end product and the by-products are present in different states of matter in the suspension used and can therefore be separated easily from one another. In this way, solvent-free amino- or hydroxyl-containing benzonitriles are obtained in high yield and significantly improved product quality.

    摘要翻译： 所要求的是制备氨基或羟基苯腈的方法，其中在氨解过程中，相应的氨基或羟基苯甲酸化合物在含有磷酸盐的负载型催化剂存在下，与氨反应，温度在250℃ 和500℃。实际的制备步骤在反应气体（混合物）中进行，而不涉及有机溶剂，然后进行至少2阶段的纯化步骤。 在该纯化步骤中，将从制备步骤获得的气体混合物首先转化为碱性悬浮液，然后将固体中存在的产物从该悬浮液中释放。 这种组合方法的主要优点是起始原料不是酯类，这就是为什么所产生的产品与其他习惯方法相反的方法不同于其他习惯的副产物，这导致高 产品纯度 所要求的方法可另外以非常经济可行的方式进行，因为最终产物和副产物以所使用的悬浮液中物质的不同状态存在，因此可以彼此容易地分离。 以这种方式，可以高产率获得无溶剂的含氨基或羟基的苯腈，并显着提高产品质量。