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    Oral forms of administration containing solid flupirtine with controlled release of active substance
    2.
    发明授权
    Oral forms of administration containing solid flupirtine with controlled release of active substance 失效
    含有活性物质控制释放的固体氟吡汀的口服形式的给药

    公开(公告)号：US06667058B1

    公开(公告)日：2003-12-23

    申请号：US08212578

    申请日：1994-03-17

    申请人： Joachim Goede ,  Helmut Hettche ,  Helmut Momberger ,  Jürgen Engel ,  Michael Lobisch

    发明人： Joachim Goede ,  Helmut Hettche ,  Helmut Momberger ,  Jürgen Engel ,  Michael Lobisch

    IPC分类号： A61K908

    CPC分类号： A61K31/44 ,  A61K9/2077 ,  A61K9/209 ,  A61K9/5078 ,  A61K9/5084

    摘要： Pharmaceutical dosage units containing flupirtine or a pharmaceutically acceptable salt of flupirtine with controlled release of active substance using a delayed-action or controlled-release component. There are 0.001 to 20 parts delayed-action component for each part by weight flupirtine (calculated as the base) and the release rate of flupirtine is between 5 and 300 mg per hour. In some cases, the dosage units may also contain a rapidly releasing component of flupirtine or of one of its salts. The dosage units reduce the sedative effect of flupirtine.

    摘要翻译： 含有氟吡汀或氟吡汀药学上可接受的盐的药物剂量单位，其使用延迟作用或控制释放组分控制释放活性物质。 对于每份重量的氟吡汀（以碱为基准计），有0.001-20份延迟作用组分，氟吡汀的释放速率为5至300mg /小时。 在一些情况下，剂量单位还可以含有氟吡汀或其一种盐的快速释放组分。 剂量单位降低氟吡汀的镇静作用。

    Pharmaceutical powder cartridge, and inhaler equipped with same
    4.
    发明授权
    Pharmaceutical powder cartridge, and inhaler equipped with same 有权
    制药粉盒和配备相同的吸入器

    公开(公告)号：US07954492B2

    公开(公告)日：2011-06-07

    申请号：US11270678

    申请日：2005-11-09

    申请人： Joachim Goede ,  Martin Herder ,  Karl-Heinz Lange ,  Meike Eilbracht

    发明人： Joachim Goede ,  Martin Herder ,  Karl-Heinz Lange ,  Meike Eilbracht

    IPC分类号： A61M15/00 ,  A61M16/00

    CPC分类号： A61M15/0065 ,  A61M15/0003 ,  A61M2202/064

    摘要： To improve administration of powdered pharmaceuticals, a pharmaceutical powder cartridge (1) for powder inhalers for holding a pharmaceutical depot for a large number of pharmaceutical powder doses is proposed, having at least one storage space (6) and an integrated metering device, said integrated metering device comprising at least one metering slide (9, 13, 14) which can be moved approximately transversely in a metering slide channel (12) at least from a filling position to an emptying position, approximately transversely with respect to the direction of flow of the pharmaceutical powder out from the at least one storage space (6), said metering slide channel (12) with the at least one metering slide (9, 13, 14) being sealed off from the environment at least in the filling position of the metering slide (9, 13, 14), and also further measures and a corresponding inhaler.

    摘要翻译： 为了改善粉末药物的给药，提出了一种用于容纳大量药物粉末剂量的药物贮库的用于粉末吸入器的药物粉盒（1），其具有至少一个储存空间（6）和一体式计量装置 计量装置包括至少一个计量滑动件（9,13,14），其可以在计量滑动通道（12）中大致横向移动至少从填充位置到排空位置，大致横向于相对于流动方向的流动方向 所述药物粉末从所述至少一个存储空间（6）出来，所述计量滑动通道（12）与所述至少一个计量滑动件（9,13,14）至少在所述至少一个计量滑动件 计量滑块（9,13,14），以及进一步措施和相应的吸入器。

    Storage system for powdered pharmaceuticals, and inhaler equipped with this system
    5.
    发明授权
    Storage system for powdered pharmaceuticals, and inhaler equipped with this system 有权
    粉末药品储存系统和配有该系统的吸入器

    公开(公告)号：US07234464B2

    公开(公告)日：2007-06-26

    申请号：US09739170

    申请日：2000-12-18

    申请人： Joachim Goede ,  Karl-Heinz Lange

    发明人： Joachim Goede ,  Karl-Heinz Lange

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0003 ,  A61M15/0066 ,  A61M2202/064

    摘要： A cartridge for powdered pharmaceuticals. At least two storage spaces are provided which are separate from each other and which are each intended to hold a multiplicity of doses of a medically active substance. The storage spaces are individual cartridges which may be lockingly coupled together to form a single cartridge. Each individual cartridge has a metering cavity.

    摘要翻译： 用于粉末药物的药筒。 提供至少两个彼此分离的储存空间，它们各自用于容纳多种剂量的医用活性物质。 存储空间是可以锁定地联接在一起以形成单个盒的各个盒。 每个单独的墨盒具有计量腔。

    Combination of Anticholinergics and Glucocorticoids for the Long-Term Treatment of Asthma and COPD
    8.
    发明申请
    Combination of Anticholinergics and Glucocorticoids for the Long-Term Treatment of Asthma and COPD 审中-公开
    组合抗胆碱能药物和糖皮质激素用于长期治疗哮喘和COPD

    公开(公告)号：US20080300226A1

    公开(公告)日：2008-12-04

    申请号：US12189598

    申请日：2008-08-11

    申请人： Joachim Goede ,  Joachim Maus ,  Peter Jurgen Cnota ,  Istvan Szelenyi

    发明人： Joachim Goede ,  Joachim Maus ,  Peter Jurgen Cnota ,  Istvan Szelenyi

    IPC分类号： A61K31/56 ,  A61P11/00 ,  A61P11/06

    摘要： The present invention describes the combination of topically inhaled medicinal formulations comprising an anticholinergic component and a glucocorticosteroid component and its use in the symptomatic and prophylactic treatment of diseases of the respiratory tract, especially with an obstructive component or underlying inflammation like asthma and chronic obstructive pulmonary disease (COPD). It further comprises the presentation of this combination in a locally applied (inhaled) formulation and application in an inhalation device for instance in the Novolizer®.

    摘要翻译： 本发明描述了包含抗胆碱能成分和糖皮质激素成分的局部吸入药物制剂的组合及其在对呼吸道疾病的症状和预防性治疗中的用途，特别是阻塞性成分或潜在炎症如哮喘和慢性阻塞性肺病 （COPD）。 它还包括将这种组合在局部施用（吸入）制剂中的应用和例如在Novolizer中的吸入装置中的应用。

    Powder formulation disintegrating system and method for dry powder inhalers
    10.
    发明授权
    Powder formulation disintegrating system and method for dry powder inhalers 有权
    粉末制剂粉碎系统和干粉吸入器的方法

    公开(公告)号：US06681768B2

    公开(公告)日：2004-01-27

    申请号：US10177433

    申请日：2002-06-21

    申请人： Anne Haaije de Boer ,  Henderik Willem Frijlink ,  Doetie Gjaltema ,  Joachim Goede ,  Paul Hagedoorn

    发明人： Anne Haaije de Boer ,  Henderik Willem Frijlink ,  Doetie Gjaltema ,  Joachim Goede ,  Paul Hagedoorn

    IPC分类号： A61M1500

    CPC分类号： A61M15/0086 ,  A61M2202/064 ,  A61M2206/16

    摘要： A disperser for dry powders which can be used with different dose systems, dose weights ranging from 2 to 25 mg and different types of powder formulation. In one embodiment, the disperser acts both as a de-agglomeration (disintegration; aerosolization) means and as an air classifier for especially adhesive mixtures. Only fine drug particles are emitted whereas the larger agglomerates and carrier crystals are retained by the disperser. Another embodiment enables time controlled release of carrier crystals in these mixtures. Yet another embodiment has optimized performance with spherical pellets, containing no carrier crystals. Other possible embodiments of the invention make it possible to control the total inhaler resistance and the powder deposition in the upper respiratory tract by means of the addition of a so-called sheath flow of clean air. Modifications also enable carrier retainment in the mouthpiece and elimination of the tangential flow component of the discharge cloud.

    摘要翻译： 用于干粉的分散机，可用于不同剂量系统，​​剂量重量范围为2至25 mg和不同类型的粉末制剂。 在一个实施方案中，分散器既作为去附聚（崩解，雾化）装置，又作为特别是粘合剂混合物的空气分级器。 只有细小的药物颗粒被排出，而较大的附聚物和载体晶体被分散器保留。 另一个实施方案允许在这些混合物中载体晶体的时间控制释放。 另一个实施方案具有不含载体晶体的球形颗粒的优化性能。 本发明的其它可能的实施方案使得可以通过添加所谓的干净空气的鞘流来控制上呼吸道中的总吸入器阻力和粉末沉积。 修改还使得容器保持在接口中并消除排出云的切向流分量。