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1.发明授权Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors 有权取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂公开(公告)号：US07595406B2
公开(公告)日：2009-09-29
申请号：US11830318
申请日：2007-07-30
申请人： Thomas D. Penning , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent L. Giranda , Viraj B. Gandhi
发明人： Thomas D. Penning , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent L. Giranda , Viraj B. Gandhi
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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2.发明授权Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors 有权取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂公开(公告)号：US07462724B2
公开(公告)日：2008-12-09
申请号：US11560166
申请日：2006-11-15
申请人： Thomas D. Penning , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent L. Giranda , Viraj B. Gandhi
发明人： Thomas D. Penning , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent L. Giranda , Viraj B. Gandhi
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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