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4 条记录 (耗时 0.042 秒)

    Drug delivery apparatus and method preventing local and systemic toxicity
    1.
    发明授权
    Drug delivery apparatus and method preventing local and systemic toxicity 失效
    药物输送装置和方法，防止局部和全身毒性

    公开(公告)号：US5024657A

    公开(公告)日：1991-06-18

    申请号：US518272

    申请日：1990-05-04

    申请人： Thomas E. Needham ,  Jeremy C. Wright ,  Steve Pearson ,  Rao Chilamkurti ,  Clinton V. Kopp

    发明人： Thomas E. Needham ,  Jeremy C. Wright ,  Steve Pearson ,  Rao Chilamkurti ,  Clinton V. Kopp

    IPC分类号： A61M5/168 ,  A61M5/14 ,  A61M39/00

    CPC分类号： A61M5/1409

    摘要： An apparatus is provided for the safe, passive reconstruction of a drug or other beneficial agent, without requiring manual reconstitution steps. The apparatus includes a housing, preferably having a receptacle "in-line" in an administration set and forming part of an intravenous delivery system, and a cartridge adapted for receiving a beneficial agent or beneficial agent and carrier. The cartridge is plugged into the receptacle to initiate reconstitution of the agent. The apparatus creates first and second delivery modes, in which the delivery rate of the agent to a patient is independent from and dependent upon, respectively, the fluid flow rate through the intravenous delivery system.

    摘要翻译： 提供了一种用于药物或其他有益药物的安全，被动重建的装置，而不需要手动重建步骤。 该装置包括壳体，其优选地具有在管理组中的“在线”插座并形成静脉内递送系统的一部分的容器，以及适于接收有益药剂或有益药剂和载体的药筒。 将墨盒插入容器以开始重新配制药剂。 该装置产生第一和第二递送模式，其中药剂对患者的递送速率独立于并且依赖于通过静脉内递送系统的流体流速。

    Method of incorporating proteins or peptides into a matrix and administration thereof through mucosa
    2.
    发明授权
    Method of incorporating proteins or peptides into a matrix and administration thereof through mucosa 失效
    将蛋白质或肽掺入基质中并通过粘膜给药的方法

    公开(公告)号：US06190699B1

    公开(公告)日：2001-02-20

    申请号：US09074778

    申请日：1998-05-08

    申请人： Louis A. Luzzi ,  Thomas E. Needham ,  Zia Hossein ,  Polireddy Dondeti

    发明人： Louis A. Luzzi ,  Thomas E. Needham ,  Zia Hossein ,  Polireddy Dondeti

    IPC分类号： A61K914

    CPC分类号： A61K9/1694 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652

    摘要： The present invention describes a surprising new and effective pharmaceutical composition comprising microparticles and a pharmaceutically acceptable carrier. In particular, the present invention describes a pharmaceutical composition containing microparticles off a matrix material into which is infused a therapeutic agent. The present invention further provides a method of infusing a therapeutic agent such as a protein or peptide into a matrix material to form microparticles containing said therapeutic agent by employing a compressed solvent which is normally gaseous at ambient temperature and pressure. A method is also disclosed of treating or preventing a disease in a mammal by administering to said mammal through a mucosal membrane an effective amount of a pharmaceutical composition comprising microparticles containing a therapeutic agent which effectively treats the disease or disorder.

    摘要翻译： 本发明描述了令人惊奇的新颖有效的药物组合物，其包含微粒和药学上可接受的载体。 特别地，本发明描述了一种药物组合物，其含有基质材料中的微粒，其中注入治疗剂。 本发明还提供了一种通过使用在环境温度和压力下通常是气体的压缩溶剂将诸如蛋白质或肽等治疗剂注入基质材料中以形成含有所述治疗剂的微粒的方法。 还公开了通过向所述哺乳动物施用有效量的含有有效治疗疾病或病症的治疗剂的含有微粒的有效量的药物组合物来治疗或预防哺乳动物疾病的方法。

    Pharmaceutical compositions for intranasal spray administration of ketorolac tromethamine
    3.
    发明授权
    Pharmaceutical compositions for intranasal spray administration of ketorolac tromethamine 失效
    鼻内喷雾给药酮咯酸氨丁三醇的药物组合物

    公开(公告)号：US6090368A

    公开(公告)日：2000-07-18

    申请号：US33994

    申请日：1998-03-03

    申请人： Hossein Zia ,  Thomas E. Needham ,  Muhammad Quadir

    发明人： Hossein Zia ,  Thomas E. Needham ,  Muhammad Quadir

    IPC分类号： A61K9/00 ,  A61K31/407 ,  A61K47/38 ,  A61L9/14

    CPC分类号： A61K9/0043 ,  A61K31/407 ,  A61K47/38 ,  Y10S514/958

    摘要： A pharmaceutical composition of a water soluble drug admixed with an aqueous bioadhesive cellulosic polymer containing microcrystalline particles. When sprayed (via a conventional spray device) into the nose, drug molecules are retained in contact with the nasal membrane. The drug composition comprises ketorolac tromethamine in an aqueous nasal polymeric spray formulation that without the addition of any permeation enhancer will promote drug absorption and provides absolute drug bioavailability greater than 90%.

    摘要翻译： 与含有微晶颗粒的水性生物粘附纤维素聚合物混合的水溶性药物的药物组合物。 当通过常规喷雾装置喷射到鼻中时，药物分子保持与鼻膜接触。 该药物组合物包含水性鼻聚合物喷雾制剂中的酮咯酸氨丁三醇，不加任何渗透促进剂将促进药物吸收并提供大于90％的绝对药物生物利用度。