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公开(公告)号：US08202692B2
公开(公告)日：2012-06-19
申请号：US12546278
申请日：2009-08-24
申请人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Dafydd G. Thomas , Yuri Nikiforov
发明人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Dafydd G. Thomas , Yuri Nikiforov
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2333/96455
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of thyroid cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译： 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供与甲状腺癌相关的基因表达谱。 使用本发明的方法鉴定为癌症标志物的基因可用于甲状腺癌的诊断和表征。 此外，这些基因为癌症药物筛选和治疗应用提供了靶标。
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公开(公告)号：US07598052B2
公开(公告)日：2009-10-06
申请号：US11545586
申请日：2006-10-10
申请人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Yuri Nikiforov , Dafydd G. Thomas
发明人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Yuri Nikiforov , Dafydd G. Thomas
IPC分类号： G01N33/574 , G01N33/53 , C12Q1/68 , C12P21/08 , C07K16/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2333/96455
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of thyroid cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译： 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供与甲状腺癌相关的基因表达谱。 使用本发明的方法鉴定为癌症标志物的基因可用于甲状腺癌的诊断和表征。 此外，这些基因为癌症药物筛选和治疗应用提供了靶标。
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公开(公告)号：US20080044824A1
公开(公告)日：2008-02-21
申请号：US11545586
申请日：2006-10-10
申请人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Yuri Nikiforov , Dafydd Thomas
发明人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Yuri Nikiforov , Dafydd Thomas
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2333/96455
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of thyroid cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译： 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供与甲状腺癌相关的基因表达谱。 使用本发明的方法鉴定为癌症标志物的基因可用于甲状腺癌的诊断和表征。 此外，这些基因为癌症药物筛选和治疗应用提供了靶标。
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公开(公告)号：US20100055704A1
公开(公告)日：2010-03-04
申请号：US12546278
申请日：2009-08-24
申请人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanash , Yuri Nikiforov , Dafydd G. Thomas
发明人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanash , Yuri Nikiforov , Dafydd G. Thomas
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2333/96455
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of thyroid cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译： 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供与甲状腺癌相关的基因表达谱。 使用本发明的方法鉴定为癌症标志物的基因可用于甲状腺癌的诊断和表征。 此外，这些基因为癌症药物筛选和治疗应用提供了靶标。
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公开(公告)号：US20130177927A9
公开(公告)日：2013-07-11
申请号：US11549050
申请日：2006-10-12
申请人： Samir M. Hanash , David G. Beer , Rork Kuick , Robert Hinderer
发明人： Samir M. Hanash , David G. Beer , Rork Kuick , Robert Hinderer
IPC分类号： G01N33/574
CPC分类号： G01N33/57446 , G01N33/57407
摘要： Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from esophageal tumors, reveals proteins which are different in tumor and control tissue.
摘要翻译： 来自食管肿瘤组织中蛋白质的载体两性电泳（CA）和固定化pH梯度（IPG）的2-D凝胶的计算机化分析揭示了在肿瘤和对照组织中不同的蛋白质。
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公开(公告)号：US20070148713A1
公开(公告)日：2007-06-28
申请号：US11549050
申请日：2006-10-12
申请人： Samir Hanash , David Beer , Rork Kuick , Robert Hinderer
发明人： Samir Hanash , David Beer , Rork Kuick , Robert Hinderer
IPC分类号： G01N33/574
CPC分类号： G01N33/57446 , G01N33/57407
摘要： Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from esophageal tumors, reveals proteins which are different in tumor and control tissue.
摘要翻译： 来自食管肿瘤组织中蛋白质的载体两性电泳（CA）和固定化pH梯度（IPG）的2-D凝胶的计算机化分析揭示了在肿瘤和对照组织中不同的蛋白质。
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