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公开(公告)号:US20060046983A1
公开(公告)日:2006-03-02
申请号:US11181639
申请日:2005-07-14
申请人: Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
发明人: Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
IPC分类号: A61K31/553 , A61K31/55 , A61K31/551 , A61K31/4745 , A61K31/407 , C07D491/04 , C07D487/04
CPC分类号: C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D513/14
摘要: Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
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公开(公告)号:US20060166964A1
公开(公告)日:2006-07-27
申请号:US11347765
申请日:2006-02-03
申请人: Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
发明人: Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
IPC分类号: A61K31/553 , A61K31/551 , A61K31/55 , C07D487/02 , C07D491/02
CPC分类号: C07D471/04 , A61K31/13 , A61K31/4745 , A61K31/7056 , A61K38/13 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D498/14 , C07D513/14 , A61K2300/00
摘要: Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
摘要翻译: 描述式I的吲哚化合物。 该化合物具有抗丙型肝炎病毒(HCV)的活性,可用于治疗HCV感染者。 还描述了包含化合物的不同形式和组合物以及制备化合物的方法。
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公开(公告)号:US07153848B2
公开(公告)日:2006-12-26
申请号:US11181639
申请日:2005-07-14
申请人: Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
发明人: Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
IPC分类号: A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/425 , A61K31/427 , A61K31/4178 , A61K31/4184 , A61K31/4025 , A61K31/403 , C07D233/32 , C07D413/14 , C07D409/14
CPC分类号: C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D513/14
摘要: Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
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公开(公告)号:US07348425B2
公开(公告)日:2008-03-25
申请号:US11347765
申请日:2006-02-03
申请人: Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
发明人: Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
IPC分类号: A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/425 , A61K31/427 , A61K31/403 , C07D233/32 , C07D413/14 , C07D409/14
CPC分类号: C07D471/04 , A61K31/13 , A61K31/4745 , A61K31/7056 , A61K38/13 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D498/14 , C07D513/14 , A61K2300/00
摘要: Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds
摘要翻译: 描述式I的吲哚化合物。 该化合物具有抗丙型肝炎病毒(HCV)的活性,可用于治疗HCV感染者。 还描述了包含化合物的不同形式和组合物以及制备化合物的方法
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公开(公告)号:US09474762B2
公开(公告)日:2016-10-25
申请号:US14716159
申请日:2015-05-19
申请人: Chao Chen , Haibing Deng , Haibing Guo , Feng He , Lei Jiang , Fang Liang , Yuan Mi , Huixin Wan , Yao-Chang Xu , Hongping Yu , Ji Yue Zhang
发明人: Chao Chen , Haibing Deng , Haibing Guo , Feng He , Lei Jiang , Fang Liang , Yuan Mi , Huixin Wan , Yao-Chang Xu , Hongping Yu , Ji Yue Zhang
IPC分类号: A61K31/00 , A61K31/551 , C07D471/04 , C07D519/00 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D491/107 , A61K31/4709
CPC分类号: A61K31/551 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D471/04 , C07D491/107 , C07D519/00
摘要: The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
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公开(公告)号:US20140004101A1
公开(公告)日:2014-01-02
申请号:US14013666
申请日:2013-08-29
申请人: Zhuoliang Chen , Christine Hiu-Tung Chen , Mark G. Charest , Miao Dai , Feng He , Lei Huangshu , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
发明人: Zhuoliang Chen , Christine Hiu-Tung Chen , Mark G. Charest , Miao Dai , Feng He , Lei Huangshu , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC分类号: C07D417/04 , A61K31/427 , A61K45/06
CPC分类号: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
摘要: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
摘要翻译: 本发明涉及下式的化合物或其药学上可接受的盐,以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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7.
公开(公告)号:US08577386B2
公开(公告)日:2013-11-05
申请号:US13133794
申请日:2008-12-30
IPC分类号: H04W72/00
CPC分类号: H04W24/10
摘要: A method for measuring and reporting resource in a long term evolution system comprises: a source base station encapsulating a resource status request message and sending the message to a target base station; after receiving the resource status request message, the target base station processing the message, and sending a resource status success response to the source base station if the processing is successful, or else sending a resource status failure response if the processing is failed; the source base station encapsulating at least a message type (2), a measurement request type (3), a source base station global identifier (4) and measurement configuration information (5) in the resource status request message, wherein, the measurement request type (3) is one or more of start, modify and end (7); the measurement configuration information (5) is measurement configuration information (5) in current measurement request type (3). The method makes it convenient to start, modify or end the current measurement by the target base station during network operation after a plurality of resource status measuring and reporting are launched between base stations, and thus reducing the number of information exchange between base stations.
摘要翻译: 一种用于在长期演进系统中测量和报告资源的方法包括:源基站封装资源状态请求消息并将消息发送到目标基站; 在接收到资源状态请求消息之后,目标基站处理该消息,并且如果处理成功则向源基站发送资源状态成功响应,或者如果处理失败则发送资源状态失败响应; 所述源基站在资源状态请求消息中至少封装消息类型(2),测量请求类型(3),源基站全局标识符(4)和测量配置信息(5),其中,所述测量请求 类型(3)是开始,修改和结束(7)中的一个或多个; 测量配置信息(5)是当前测量请求类型(3)中的测量配置信息(5)。 该方法使得在基站之间启动多个资源状态测量和报告之后,网络操作期间目标基站的启动,修改或结束方便,从而减少基站之间的信息交换次数。
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公开(公告)号:US08507676B2
公开(公告)日:2013-08-13
申请号:US13567386
申请日:2012-08-06
申请人: Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-Chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
发明人: Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-Chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
IPC分类号: C07D487/04 , C07D403/12 , A61K31/4985 , A61P35/00
CPC分类号: C07D471/04
摘要: The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
摘要翻译: 本发明涉及式(I)的化合物及其盐:其中取代基如说明书中所定义; 用于治疗人或动物体的式(I)化合物,特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式(I)化合物制备用于治疗这些疾病的药物; 包含式(I)化合物,任选在组合配偶体存在下的药物组合物,以及制备式(I)化合物的方法。
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公开(公告)号:US08410264B2
公开(公告)日:2013-04-02
申请号:US12859653
申请日:2010-08-19
申请人: Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
发明人: Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
IPC分类号: C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号: C07D471/04
摘要: The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
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公开(公告)号:US20110015232A1
公开(公告)日:2011-01-20
申请号:US12445435
申请日:2007-10-10
申请人: Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
发明人: Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
IPC分类号: A61K31/4439 , C07D405/14 , C07D401/14 , C12N5/07
CPC分类号: C07K5/06191
摘要: The present invention relates to novel IAP inhibitor compounds of: Formula (I).
摘要翻译: 本发明涉及式(I)的新型IAP抑制剂化合物。
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