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公开(公告)号：US20140004101A1
公开(公告)日：2014-01-02
申请号：US14013666
申请日：2013-08-29
Applicant: Zhuoliang Chen , Christine Hiu-Tung Chen , Mark G. Charest , Miao Dai , Feng He , Lei Huangshu , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
Inventor： Zhuoliang Chen , Christine Hiu-Tung Chen , Mark G. Charest , Miao Dai , Feng He , Lei Huangshu , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC: C07D417/04 , A61K31/427 , A61K45/06
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号：US20110319614A1
公开(公告)日：2011-12-29
申请号：US13228221
申请日：2011-09-08
Applicant: Zhuoliang CHEN , Run-Ming David WANG , Ming CHEN , Christopher Sean STRAUB , Leigh ZAWEL
Inventor： Zhuoliang CHEN , Run-Ming David WANG , Ming CHEN , Christopher Sean STRAUB , Leigh ZAWEL
IPC: C07D241/18 , C07D401/06 , C07D403/14 , C07D401/14 , C07D413/14 , C07D239/36 , C07D413/10
CPC classification number: C07D241/20 , C07D239/47 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D417/06
Abstract: The present invention relates to novel IAP inhibitor compounds of formula I:
Abstract translation: 本发明涉及式I的新型IAP抑制剂化合物：
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公开(公告)号：US20110015232A1
公开(公告)日：2011-01-20
申请号：US12445435
申请日：2007-10-10
Applicant: Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
Inventor： Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
IPC: A61K31/4439 , C07D405/14 , C07D401/14 , C12N5/07
CPC classification number: C07K5/06191
Abstract: The present invention relates to novel IAP inhibitor compounds of: Formula (I).
Abstract translation: 本发明涉及式（I）的新型IAP抑制剂化合物。
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![(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-4-(4-fluorobenzoyl)-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl)-2-methylamino-propionamide, or pharmaceutically acceptable salts thereof and their uses](/abs-image/US/2013/10/08/US08552003B2/abs.jpg.150x150.jpg)
4.发明授权(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-4-(4-fluorobenzoyl)-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl)-2-methylamino-propionamide, or pharmaceutically acceptable salts thereof and their uses 有权（S）-N - （（S）-1-环己基-2 - {（S）-2- [4-4-（4-氟苯甲酰基） - 噻唑-2-基]吡咯烷-1-基} -2- 氧代乙基）-2-甲基氨基 - 丙酰胺或其药学上可接受的盐及其用途公开(公告)号：US08552003B2
公开(公告)日：2013-10-08
申请号：US12376057
申请日：2007-07-31
Applicant: Mark G. Charest , Christine Hiu-Tung Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
Inventor： Mark G. Charest , Christine Hiu-Tung Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC: A01N43/54
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号：US20130005663A1
公开(公告)日：2013-01-03
申请号：US13606676
申请日：2012-09-07
Applicant: Mark G. CHAREST , Christine Hiu-Tung CHEN , Zhuoliang CHEN , Miao DAI , Feng HE , Huangshu LEI , Ly Luu PHAM , Sushil Kumar SHARMA , Christopher Sean STRAUB , Run-Ming David WANG , Fan YANG , Leigh ZAWEL
Inventor： Mark G. CHAREST , Christine Hiu-Tung CHEN , Zhuoliang CHEN , Miao DAI , Feng HE , Huangshu LEI , Ly Luu PHAM , Sushil Kumar SHARMA , Christopher Sean STRAUB , Run-Ming David WANG , Fan YANG , Leigh ZAWEL
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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Patent Agency Ranking
公开(公告)号：US08058272B2
公开(公告)日：2011-11-15
申请号：US12518195
申请日：2007-12-07
Applicant: Zhuoliang Chen , Run-Ming David Wang , Ming Chen , Christopher Sean Straub , Leigh Zawel
Inventor： Zhuoliang Chen , Run-Ming David Wang , Ming Chen , Christopher Sean Straub , Leigh Zawel
IPC: C07D401/02 , A61K31/44
CPC classification number: C07D405/12 , C07D213/75 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/06
Abstract: The present disclosure relates to XIAP inhibitor compound of the formula I:
Abstract translation: 本公开涉及式I的XIAP抑制剂化合物：
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公开(公告)号：US08044209B2
公开(公告)日：2011-10-25
申请号：US12445435
申请日：2007-10-10
Applicant: Mark G. Charest , Christine Hiu-Tung Chen , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Sean Straub , Run-Ming David Wang , Leigh Zawel
Inventor： Mark G. Charest , Christine Hiu-Tung Chen , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Sean Straub , Run-Ming David Wang , Leigh Zawel
IPC: A61K31/4439 , C07D405/14 , C07D401/14
CPC classification number: C07K5/06191
Abstract: The present invention relates to novel IAP inhibitor compounds of: Formula (I).
Abstract translation: 本发明涉及式（I）的新型IAP抑制剂化合物。
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公开(公告)号：US20110065726A1
公开(公告)日：2011-03-17
申请号：US12376057
申请日：2007-07-31
Applicant: Zhuoliang CHEN , Sushil Kumar Sharma , Christopher Straub , Mark G. Charest , Feng He , Run-Ming David Wang , Leigh Zawel , Christine Hiu-Tung Chen , Miao Dai , Huangshu Lei , Ly Pham , Fan Yang
Inventor： Zhuoliang CHEN , Sushil Kumar Sharma , Christopher Straub , Mark G. Charest , Feng He , Run-Ming David Wang , Leigh Zawel , Christine Hiu-Tung Chen , Miao Dai , Huangshu Lei , Ly Pham , Fan Yang
IPC: C07D401/12 , A61P35/04 , A61K31/44 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/506 , C07D413/12 , C07D417/12
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号：US20100249405A1
公开(公告)日：2010-09-30
申请号：US12518184
申请日：2007-12-07
Applicant: Zhuoliang Chen , Run-Ming David Wang , Ming Chen , Christopher Sean Straub , Leigh Zawel
Inventor： Zhuoliang Chen , Run-Ming David Wang , Ming Chen , Christopher Sean Straub , Leigh Zawel
IPC: C07D413/10 , C07D241/20 , C07D239/47 , C07D401/06 , C07D403/14
CPC classification number: C07D241/20 , C07D239/47 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D417/06
Abstract: The present invention relates to novel IAP inhibitor compounds of formula I:
Abstract translation: 本发明涉及式I的新型IAP抑制剂化合物：
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公开(公告)号：US08546336B2
公开(公告)日：2013-10-01
申请号：US13606676
申请日：2012-09-07
Applicant: Zhuoliang Chen , Mark G. Charest , Christine Hiu-Tung Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
Inventor： Zhuoliang Chen , Mark G. Charest , Christine Hiu-Tung Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC: A61K38/00
CPC classification number: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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