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公开(公告)号:US20110015232A1
公开(公告)日:2011-01-20
申请号:US12445435
申请日:2007-10-10
申请人: Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
发明人: Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
IPC分类号: A61K31/4439 , C07D405/14 , C07D401/14 , C12N5/07
CPC分类号: C07K5/06191
摘要: The present invention relates to novel IAP inhibitor compounds of: Formula (I).
摘要翻译: 本发明涉及式(I)的新型IAP抑制剂化合物。
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公开(公告)号:US20110065726A1
公开(公告)日:2011-03-17
申请号:US12376057
申请日:2007-07-31
申请人: Zhuoliang CHEN , Sushil Kumar Sharma , Christopher Straub , Mark G. Charest , Feng He , Run-Ming David Wang , Leigh Zawel , Christine Hiu-Tung Chen , Miao Dai , Huangshu Lei , Ly Pham , Fan Yang
发明人: Zhuoliang CHEN , Sushil Kumar Sharma , Christopher Straub , Mark G. Charest , Feng He , Run-Ming David Wang , Leigh Zawel , Christine Hiu-Tung Chen , Miao Dai , Huangshu Lei , Ly Pham , Fan Yang
IPC分类号: C07D401/12 , A61P35/04 , A61K31/44 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/506 , C07D413/12 , C07D417/12
CPC分类号: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
摘要: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
摘要翻译: 本发明涉及下式的化合物或其药学上可接受的盐,以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。
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公开(公告)号:US20080242658A1
公开(公告)日:2008-10-02
申请号:US10594413
申请日:2005-04-06
申请人: Mark G Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
发明人: Mark G Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC分类号: A61K31/407 , C07D471/04 , C07D207/08 , C07D487/04 , C07D207/32 , A61P35/00 , A61K31/4439 , A61K31/422 , A61K31/41 , A61K31/506 , C07D401/04 , C07D403/12 , A61K31/437 , A61K31/55 , A61K31/40
CPC分类号: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
摘要翻译: 抑制Smac蛋白与抑制凋亡蛋白抑制剂(IAP)的新型化合物
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公开(公告)号:US20050234042A1
公开(公告)日:2005-10-20
申请号:US11099941
申请日:2005-04-06
申请人: Mark Palermo , Sushil Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark Charest , Feng He
发明人: Mark Palermo , Sushil Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark Charest , Feng He
IPC分类号: A61K31/40 , A61K31/4025 , A61K31/437 , A61K31/4745 , A61K31/55 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/04
CPC分类号: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
摘要翻译: 抑制Smac蛋白与抑制凋亡蛋白抑制剂(IAP)的新型化合物
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公开(公告)号:US07419975B2
公开(公告)日:2008-09-02
申请号:US11099941
申请日:2005-04-06
申请人: Mark Gabriel Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Scott Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
发明人: Mark Gabriel Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Scott Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC分类号: A61K31/407 , A61K31/437 , A61K31/55 , C07D487/04 , C07D471/04
CPC分类号: C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
摘要翻译: 抑制Smac蛋白与抑制凋亡蛋白抑制剂(IAP)的新型化合物
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公开(公告)号:US08445440B2
公开(公告)日:2013-05-21
申请号:US13033463
申请日:2011-02-23
申请人: Christopher Straub , Zhuoliang Chen , Mark Palermo
发明人: Christopher Straub , Zhuoliang Chen , Mark Palermo
CPC分类号: C07D401/14 , C07K5/06026
摘要: The present invention provides compounds of formula M-L-M′ (where M and M′ are each independently a monomeric moiety of Formula (I) and L is a linker). The dimeric compounds have been found to be effective in promoting apoptosis in rapidly dividing cells.
摘要翻译: 本发明提供式M-L-M'的化合物(其中M和M'各自独立地为式(I)的单体部分,L为连接基)。 已经发现二聚体化合物在促进快速分裂细胞中的凋亡方面是有效的。
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7.2-Aminocarbonyl Substituted Piperazine or Diaza-Cyclic Compounds as Apoptosis Protein Inhibitors (Iap) Modulators 失效
标题翻译: 2-氨基羰基取代的哌嗪或二氮杂环化合物作为凋亡蛋白抑制剂(Iap)调节剂公开(公告)号:US20080207630A1
公开(公告)日:2008-08-28
申请号:US11911418
申请日:2006-04-13
申请人: Robert Eckl , Roswitha Taube , Michael Almstetter , Michael Thormann , Andreas Treml , Christopher Straub , Zhuoliang Chen
发明人: Robert Eckl , Roswitha Taube , Michael Almstetter , Michael Thormann , Andreas Treml , Christopher Straub , Zhuoliang Chen
IPC分类号: A61K31/496 , C07D241/04 , A61P35/04
CPC分类号: C07D241/04 , C07D295/185 , C07D401/04 , C07D403/06 , C07K5/06052 , C07K5/0806 , C07K7/06
摘要: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates or pharmaceutically acceptable formulations thereof. These compounds may be used to modulate cellular proliferation and to prevent and/or treat proliferative diseases.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物,水合物或其药学上可接受的制剂。 这些化合物可用于调节细胞增殖并预防和/或治疗增殖性疾病。
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8.2-aminocarbonyl substituted piperazine or diaza-cyclic compounds as apoptosis protein inhibitors (lap) modulators 失效
标题翻译: 2-氨基羰基取代的哌嗪或二氮杂环化合物作为凋亡蛋白抑制剂(lap)调节剂公开(公告)号:US07932255B2
公开(公告)日:2011-04-26
申请号:US11911418
申请日:2006-04-13
申请人: Robert Eckl , Roswitha Taube , Michael Almstetter , Michael Thormann , Andreas Treml , Christopher Straub , Zhouliang Chen
发明人: Robert Eckl , Roswitha Taube , Michael Almstetter , Michael Thormann , Andreas Treml , Christopher Straub , Zhouliang Chen
IPC分类号: A61K31/4965 , A61K31/00 , C07D241/04 , C07D295/00 , C07D243/08 , A01N43/00
CPC分类号: C07D241/04 , C07D295/185 , C07D401/04 , C07D403/06 , C07K5/06052 , C07K5/0806 , C07K7/06
摘要: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates or pharmaceutically acceptable formulations thereof. These compounds may be used to modulate cellular proliferation and to prevent and/or treat proliferative diseases.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物,水合物或其药学上可接受的制剂。 这些化合物可用于调节细胞增殖并预防和/或治疗增殖性疾病。
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