-
1.Methods of making FGF-21 mutants comprising non-naturally encoded phenylalanine derivatives 有权
标题翻译: 制备包含非天然编码的苯丙氨酸衍生物的FGF-21突变体的方法公开(公告)号:US08383365B2
公开(公告)日:2013-02-26
申请号:US13051953
申请日:2011-03-18
申请人: Thomas P. Cujec , Roberto Mariani , Anna-Maria A. Hays Putnam , William M. Keefe , Nick Knudsen , Lillian Skidmore (Nee Ho) , Jason Pinkstaff , Vadim Kraynov
发明人: Thomas P. Cujec , Roberto Mariani , Anna-Maria A. Hays Putnam , William M. Keefe , Nick Knudsen , Lillian Skidmore (Nee Ho) , Jason Pinkstaff , Vadim Kraynov
CPC分类号: C07K14/50 , A61K38/00 , A61K38/1825 , A61K45/06 , A61K47/60 , C12N15/70 , Y02A50/473
摘要: Modified FGF-21 polypeptides and uses thereof are provided.
摘要翻译: 提供了修饰的FGF-21多肽及其用途。
-
公开(公告)号:US08012931B2
公开(公告)日:2011-09-06
申请号:US12051830
申请日:2008-03-19
申请人: Thomas P. Cujec , Roberto Mariani , Anna-Maria A. Hays Putnam , William M. Keefe , Nick Knudsen , Lillian Ho , Jason Pinkstaff , Vadim Kraynov
发明人: Thomas P. Cujec , Roberto Mariani , Anna-Maria A. Hays Putnam , William M. Keefe , Nick Knudsen , Lillian Ho , Jason Pinkstaff , Vadim Kraynov
CPC分类号: C07K14/50 , A61K38/00 , A61K38/1825 , A61K45/06 , A61K47/60 , C12N15/70 , Y02A50/473
摘要: Modified FGF-21 polypeptides and uses thereof are provided.
摘要翻译: 提供了修饰的FGF-21多肽及其用途。
-
公开(公告)号:US08114630B2
公开(公告)日:2012-02-14
申请号:US12112890
申请日:2008-04-30
申请人: Vadim Kraynov , Nick Knudsen , Anna-Maria A. Hays Putnam , Denise Krawitz , Jason Pinkstaff , Heather Myler
发明人: Vadim Kraynov , Nick Knudsen , Anna-Maria A. Hays Putnam , Denise Krawitz , Jason Pinkstaff , Heather Myler
CPC分类号: C07K14/565 , A61K38/00
摘要: Modified interferon beta polypeptides and uses thereof are provided.
摘要翻译: 提供了修饰的干扰素β多肽及其用途。
-
公开(公告)号:US09938333B2
公开(公告)日:2018-04-10
申请号:US12863947
申请日:2009-02-05
申请人: Vadim Kraynov , Anna-Maria A. Hays Putnam , Nick Knudsen , Jason Pinkstaff , Heather Myler , Lorraine Sullivan
发明人: Vadim Kraynov , Anna-Maria A. Hays Putnam , Nick Knudsen , Jason Pinkstaff , Heather Myler , Lorraine Sullivan
IPC分类号: A61K38/22 , C07K14/575
CPC分类号: C07K14/5759
摘要: Modified human leptin polypeptides and uses thereof are provided.
-
公开(公告)号:US08329869B2
公开(公告)日:2012-12-11
申请号:US13344891
申请日:2012-01-06
申请人: Vadim Kraynov , Nick Knudsen , Anna-Maria A. Hays Putnam , Denise Krawitz , Jason Pinkstaff , Heather Myler
发明人: Vadim Kraynov , Nick Knudsen , Anna-Maria A. Hays Putnam , Denise Krawitz , Jason Pinkstaff , Heather Myler
CPC分类号: C07K14/565 , A61K38/00
摘要: Modified interferon beta polypeptides and uses thereof are provided.
-
公开(公告)号:US20120149636A1
公开(公告)日:2012-06-14
申请号:US12863947
申请日:2009-02-05
申请人: Vadim Kraynov , Anna-Maria A. Hays Putnam , Nick Knudsen , Jason Pinkstaff , Heather Myler , Lorraine Sullivan
发明人: Vadim Kraynov , Anna-Maria A. Hays Putnam , Nick Knudsen , Jason Pinkstaff , Heather Myler , Lorraine Sullivan
IPC分类号: A61K38/22 , C07K19/00 , C12N15/16 , A61P3/04 , C12N1/21 , C12N5/10 , C12N1/19 , C12P21/00 , C07K14/575 , C07K1/107
CPC分类号: C07K14/5759
摘要: Modified human leptin polypeptides and uses thereof are provided.
摘要翻译: 提供了修饰的人瘦蛋白多肽及其用途。
-
公开(公告)号:US20100135959A1
公开(公告)日:2010-06-03
申请号:US11916026
申请日:2006-06-02
申请人: Anna-Maria A. Hays Putnam , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
发明人: Anna-Maria A. Hays Putnam , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
CPC分类号: C07K14/555 , A61K38/00 , C07K14/56
摘要: Modified human interferon polypeptides and uses thereof are provided.
摘要翻译: 提供了修饰的人干扰素多肽及其用途。
-
公开(公告)号:US10138283B2
公开(公告)日:2018-11-27
申请号:US12507237
申请日:2009-07-22
申请人: Anna-Maria A. Hays Putnam , Nick Knudsen , Thea Norman , Alan Koder , Vadim Kraynov , Lillian Ho , Peter C. Canning
发明人: Anna-Maria A. Hays Putnam , Nick Knudsen , Thea Norman , Alan Koder , Vadim Kraynov , Lillian Ho , Peter C. Canning
IPC分类号: C07K14/535 , A61K38/22 , A61K38/19
摘要: Modified bovine G-CSF polypeptides and uses thereof are provided.
-
公开(公告)号:US08946148B2
公开(公告)日:2015-02-03
申请号:US12740619
申请日:2008-11-20
申请人: Zhenwei Miao , Denise Krawitz , Vadim Kraynov , Feng Tian , Bee-Cheng Sim , Lillian Skidmore , Anna-Maria A. Hays Putnam , Nick Knudsen , Michael Deguzman
发明人: Zhenwei Miao , Denise Krawitz , Vadim Kraynov , Feng Tian , Bee-Cheng Sim , Lillian Skidmore , Anna-Maria A. Hays Putnam , Nick Knudsen , Michael Deguzman
摘要: Modified insulin polypeptides and their uses thereof are provided.
摘要翻译: 提供了修饰的胰岛素多肽及其用途。
-
公开(公告)号:US08691940B2
公开(公告)日:2014-04-08
申请号:US13212101
申请日:2011-08-17
申请人: Vadim Kraynov , Nick Knudsen , Ahma Hewet , Kristine De Dios , Jason Pinkstaff , Lorraine Sullivan
发明人: Vadim Kraynov , Nick Knudsen , Ahma Hewet , Kristine De Dios , Jason Pinkstaff , Lorraine Sullivan
摘要: Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin.
-
-
-
-
-
-
-
-
-