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公开(公告)号：US07232806B2
公开(公告)日：2007-06-19
申请号：US10490955
申请日：2002-09-27
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRNA, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
摘要翻译： 在秀丽隐杆线虫中，lin-4和let-7分别编码22和21个核苷酸的RNA，其作为发育时机的关键调节剂。 因为这些短RNA的出现在发育过程中被调节，所以它们也被称为“小时间RNA”（stRNA）。 我们显示，更多的21和22-nt表达的RNA，称为microRNA（miRNA），存在于无脊椎动物和脊椎动物中，并且与let-7 stRNA相似的这些新型RNA中的一些也是高度保守的。 这表明由小RNA介导的序列特异性转录后调控机制比以前赞赏更为普遍。
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公开(公告)号：US08198428B2
公开(公告)日：2012-06-12
申请号：US12775952
申请日：2010-05-07
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21 -nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
摘要翻译： 在秀丽隐杆线虫中，lin-4和let-7分别包含22和21个核苷酸RNA，其作为发育时间的关键调节剂。 因为这些短RNA的出现在发育过程中被调节，所以它们也被称为“小时间RNA”（stRNA）。 我们显示，更多的21和22-nt表达的RNA，称为microRNA（miRNA），存在于无脊椎动物和脊椎动物中，并且与let-7 stRAN相似的这些新型RNA中的一些也是高度保守的。 这表明由小RNA介导的序列特异性转录后调控机制比以前赞赏更为普遍。
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公开(公告)号：US20100093837A1
公开(公告)日：2010-04-15
申请号：US12550602
申请日：2009-08-31
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
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公开(公告)号：US20130245090A1
公开(公告)日：2013-09-19
申请号：US13472826
申请日：2012-05-16
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
摘要翻译： 在秀丽隐杆线虫中，lin-4和let-7分别包含22个和21个核苷酸的RNA，其作为发育时机的关键调节剂。 因为这些短RNA的出现在发育过程中被调节，所以它们也被称为“小时间RNA”（stRNA）。 我们显示，更多的21和22-nt表达的RNA，称为microRNA（miRNA），存在于无脊椎动物和脊椎动物中，并且与let-7 stRAN相似的这些新型RNA中的一些也是高度保守的。 这表明由小RNA介导的序列特异性转录后调控机制比以前赞赏更为普遍。
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公开(公告)号：US07838661B2
公开(公告)日：2010-11-23
申请号：US12550586
申请日：2009-08-31
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
摘要翻译： 在秀丽隐杆线虫中，lin-4和let-7分别包含22个和21个核苷酸的RNA，其作为发育时机的关键调节剂。 因为这些短RNA的出现在发育过程中被调节，所以它们也被称为“小时间RNA”（stRNA）。 我们显示，更多的21和22-nt表达的RNA，称为microRNA（miRNA），存在于无脊椎动物和脊椎动物中，并且与let-7 stRAN相似的这些新型RNA中的一些也是高度保守的。 这表明由小RNA介导的序列特异性转录后调控机制比以前赞赏更为普遍。
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公开(公告)号：US20100286245A1
公开(公告)日：2010-11-11
申请号：US12775947
申请日：2010-05-07
IPC分类号： A61K31/7088 , C07H21/00 , C12N15/63 , A61P35/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21 -nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
摘要翻译： 在秀丽隐杆线虫中，lin-4和let-7分别包含22和21个核苷酸RNA，其作为发育时间的关键调节剂。 因为这些短RNA的出现在发育过程中被调节，所以它们也被称为“小时间RNA”（stRNA）。 我们显示，更多的21和22-nt表达的RNA，称为microRNA（miRNA），存在于无脊椎动物和脊椎动物中，并且与let-7 stRAN相似的这些新型RNA中的一些也是高度保守的。 这表明由小RNA介导的序列特异性转录后调控机制比以前赞赏更为普遍。
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公开(公告)号：US07838662B2
公开(公告)日：2010-11-23
申请号：US12550596
申请日：2009-08-31
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
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公开(公告)号：US07723510B1
公开(公告)日：2010-05-25
申请号：US11747409
申请日：2007-05-11
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
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公开(公告)号：US20100087513A1
公开(公告)日：2010-04-08
申请号：US12550586
申请日：2009-08-31
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
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公开(公告)号：US20100087512A1
公开(公告)日：2010-04-08
申请号：US12550579
申请日：2009-08-31
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
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