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1.Inducible small RNA expression constructs for targeted gene silencing 有权
标题翻译: 用于靶向基因沉默的诱导型小RNA表达构建体公开(公告)号:US08198077B2
公开(公告)日:2012-06-12
申请号:US10542592
申请日:2004-01-15
申请人: Thomas Tuschl , Tilmann Achsel , Reinhard Lührmann , Jutta Meyer
发明人: Thomas Tuschl , Tilmann Achsel , Reinhard Lührmann , Jutta Meyer
IPC分类号: C12N15/00
CPC分类号: C12N15/111 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/0058 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30
摘要: The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mammalian cells and transgenic animals.
摘要翻译: 本发明涉及用于在真核细胞,特别是哺乳动物细胞和转基因动物中可诱导表达RNA分子的载体。
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公开(公告)号:US20120255045A1
公开(公告)日:2012-10-04
申请号:US13438170
申请日:2012-04-03
申请人: Thomas Tuschl , Tilmann Achsel , Reinhard Lührmann , Jutta Meyer
发明人: Thomas Tuschl , Tilmann Achsel , Reinhard Lührmann , Jutta Meyer
IPC分类号: A61K31/7088 , C12N15/85 , A61P37/00 , A61P35/00 , A61P29/00 , A61P31/00 , A01K67/027 , C12Q1/68
CPC分类号: C12N15/111 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/0058 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30
摘要: The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mam
摘要翻译: 本发明涉及用于在真核生物,特别是母体中可诱导表达RNA分子的载体
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公开(公告)号:US06579681B1
公开(公告)日:2003-06-17
申请号:US09857063
申请日:2001-11-27
申请人: Christoph Hüls , Bettina Bauer , Claus Simandi , Reinhard Lührmann , Tilmann Achsel , Hans-Peter Vornlocher
发明人: Christoph Hüls , Bettina Bauer , Claus Simandi , Reinhard Lührmann , Tilmann Achsel , Hans-Peter Vornlocher
IPC分类号: C12Q168
CPC分类号: G01N33/5308 , C12Q1/6883
摘要: The present invention relates to a test system comprising (a) one or more identical or different immobilized nucleic acid(s) having at least one spliceable nucleic acid, (b) at least one gel-free detection system for detecting a splicing reaction, where appropriate (c) at least one composition comprising splicing components, and preferably (d) suitable detection probes, and, where appropriate, (e) further aids.
摘要翻译: 本发明涉及包含(a)一种或多种相同或不同的具有至少一个可剪接核酸的固定化核酸的测试系统,(b)至少一种用于检测剪接反应的无凝胶检测系统,其中 (c)至少一种组合物,其包含剪接组分,优选(d)合适的检测探针,以及在适当的情况下,(e)进一步的辅助剂。
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公开(公告)号:US20120246747A1
公开(公告)日:2012-09-27
申请号:US13329710
申请日:2011-12-19
IPC分类号: C07H21/02 , C12N5/02 , A01K67/027 , C12N5/10
CPC分类号: C12N15/113 , A61K47/549 , A61K47/557 , C07K14/4705 , C07K19/00 , C12N15/111 , C12N2310/14 , C12N2310/351 , C12N2310/3513 , C12N2320/30 , C12N2320/51 , C12N2330/30
摘要: The present invention relates to sequence and structural features of single-stranded (ss)RNA molecules required to mediate target-specific nucleic acid modifications by RNA-interference (RNAi), such as target mRNA degradation and/or DNA methylation.
摘要翻译: 本发明涉及通过RNA干扰(RNAi)介导靶特异性核酸修饰所需的单链(ss)RNA分子的序列和结构特征,例如靶mRNA降解和/或DNA甲基化。
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