公开(公告)号：US20240299565A1

公开(公告)日：2024-09-12

申请号：US18502473

申请日：2023-11-06

申请人： Thornhill Therapeutics, Inc.

发明人： Keyi Liu ,  Julia Dawn Mackay ,  Weijun Feng ,  Thomas Carl Hunter ,  Randall J. Mrsny

IPC分类号： A61K47/64 ,  A61K9/00 ,  A61K38/21 ,  A61K38/27 ,  A61K47/65

CPC分类号： A61K47/6415 ,  A61K9/0043 ,  A61K9/007 ,  A61K38/21 ,  A61K38/27 ,  A61K47/65

摘要： The present disclosure relates to isolated non-naturally occurring delivery constructs comprising a bacterial toxin-derived delivery construct coupled to a biologically active therapeutic cargo; wherein the delivery construct is capable of delivering the biologically active cargo via transcytosis transport across an epithelial cell; and wherein the delivery construct does not comprise a bacterial toxin-derived translocation domain or a bacterial toxin-derived catalytic (cytotoxic) domain.

公开(公告)号：US20240238429A1

公开(公告)日：2024-07-18

申请号：US18241744

申请日：2023-09-01

申请人： Thornhill Therapeutics, Inc

发明人： Randall J. Mrsny ,  Tahir Mahmood ,  Charles Olson ,  Weijun Feng

IPC分类号： A61K47/64 ,  A61K38/20 ,  A61P1/00 ,  C07K1/18

CPC分类号： A61K47/642 ,  A61K38/20 ,  A61P1/00 ,  C07K1/18

摘要： The present disclosure provides non-naturally occurring fusion molecules comprising therapeutic cargo moieties, such as IL-22 with a carrier. The disclosure also provides methods and compositions for the production, purification, refolding, formulation, and administration of fusion molecules. Methods and for using the purified molecules to treat and prevent diseases or disorders are also provided herein.