公开(公告)号：US08195417B2

公开(公告)日：2012-06-05

申请号：US12219610

申请日：2008-07-24

申请人： Thorsten Feiweier ,  Ralf Ladebeck ,  Diana Martin ,  Hartwig Newiger ,  Josef Pfeuffer ,  Michael Szimtenings ,  Harald Werthner

发明人： Thorsten Feiweier ,  Ralf Ladebeck ,  Diana Martin ,  Hartwig Newiger ,  Josef Pfeuffer ,  Michael Szimtenings ,  Harald Werthner

IPC分类号： G01R35/00

CPC分类号： A61B6/032 ,  A61B5/11 ,  A61B5/7285 ,  A61B6/037 ,  A61B6/5247 ,  A61B6/541 ,  A61B8/00 ,  A61B8/4416 ,  A61B90/36 ,  A61B2090/364 ,  G06F19/00

摘要： Disclosed is a method and apparatus for recording measured data from a patient by taking movements into account by use of a medical device designed both for recording motion-related measured data and for recording nuclear medicine measured data. The method may include recording nuclear medicine measured data by use of the medical device, simultaneously recording motion-related measured data by use of the medical device, determining at least one motion information item relating to at least one movement of the patient and/or at least one movement inside the body of the patient during the ongoing measured data recording by evaluating at least a portion of the previously recorded motion-related measured data, and carrying out motion correction for at least a portion of the nuclear medicine measured data by use of the computational device in parallel with recording the measured data.

摘要翻译： 公开了一种通过使用设计用于记录运动相关测量数据和记录核医学测量数据的医疗装置来考虑运动来记录来自患者的测量数据的方法和装置。 该方法可以包括通过使用医疗装置记录核医学测量数据，同时通过使用医疗装置记录与运动有关的测量数据，确定与患者的至少一个运动有关的至少一个运动信息项和/或在 通过评估先前记录的运动相关测量数据的至少一部分，以及通过使用以下方式对至少一部分核医学测量数据执行运动校正，在进行中的测量数据记录期间在患者体内进行至少一次运动 计算设备并行记录测量数据。

公开(公告)号：US20090041318A1

公开(公告)日：2009-02-12

申请号：US12219613

申请日：2008-07-24

申请人： Thorsten Feiweier ,  Ralf Ladebeck ,  Diana Martin ,  Hartwig Newiger ,  Josef Pfeuffer ,  Michael Szimtenings ,  Harald Werthner

发明人： Thorsten Feiweier ,  Ralf Ladebeck ,  Diana Martin ,  Hartwig Newiger ,  Josef Pfeuffer ,  Michael Szimtenings ,  Harald Werthner

IPC分类号： G01R33/56 ,  G01R33/54

CPC分类号： A61B6/032 ,  A61B5/11 ,  A61B5/7285 ,  A61B6/037 ,  A61B6/541 ,  A61B8/00 ,  A61B8/4416 ,  G06F19/00

摘要： A method is disclosed for recording measured data of a patient while taking account of movement operations by way of a medical device that is designed both for recording movement-related measured data, in particular measured data of high temporal resolution and/or measured data that can be interpolated with regard to movement operations, with the aid of an imaging method and/or by means of at least one sensor element, and also for recording nuclear medicine measured data, in particular of lower temporal resolution. In at least one embodiment, the method includes recording nuclear medicine measured data with the aid of the medical device; simultaneously recording movement-related measured data with the aid of the medical device; determining at least one item of movement information relating to at least one movement operation of the patient and/or in the body of the patient by evaluating at least a portion of the recorded measured data of high temporal resolution on the part of a computing device of the medical device; and adapting at least one item of attenuation correction information available for the computing device and serving for reconstructing the nuclear medicine measured data, doing so as a function of the at least one determined item of movement information.

摘要翻译： 公开了一种用于记录患者的测量数据的方法，同时考虑到通过设计用于记录运动相关测量数据的医疗设备，特别是高时间分辨率的测量数据和/或可测量数据的测量数据， 借助于成像方法和/或通过至少一个传感器元件，以及用于记录核医学测量数据，特别是用于记录较低时间分辨率的内插关于移动操作。 在至少一个实施例中，该方法包括借助医疗装置记录核医学测量数据; 借助医疗设备同时记录运动相关测量数据; 通过在计算设备的一部分上评估所记录的高时间分辨率测量数据的至少一部分来确定与患者的至少一个移动操作和/或患者身体有关的至少一个移动信息项 医疗器械; 以及修改可用于所述计算设备的至少一项衰减校正信息，并且用于重构所述核医学测量数据，作为所述至少一个确定的运动信息项的函数。

公开(公告)号：US08180128B2

公开(公告)日：2012-05-15

申请号：US12219613

申请日：2008-07-24

申请人： Thorsten Feiweier ,  Ralf Ladebeck ,  Diana Martin ,  Hartwig Newiger ,  Josef Pfeuffer ,  Michael Szimtenings ,  Harald Werthner

发明人： Thorsten Feiweier ,  Ralf Ladebeck ,  Diana Martin ,  Hartwig Newiger ,  Josef Pfeuffer ,  Michael Szimtenings ,  Harald Werthner

IPC分类号： G01R33/56 ,  G01R33/54

CPC分类号： A61B6/032 ,  A61B5/11 ,  A61B5/7285 ,  A61B6/037 ,  A61B6/541 ,  A61B8/00 ,  A61B8/4416 ,  G06F19/00

摘要： A method is disclosed for recording measured data of a patient while taking account of movement operations by way of a medical device that is designed both for recording movement-related measured data, in particular measured data of high temporal resolution and/or measured data that can be interpolated with regard to movement operations, with the aid of an imaging method and/or by means of at least one sensor element, and also for recording nuclear medicine measured data, in particular of lower temporal resolution. In at least one embodiment, the method includes recording nuclear medicine measured data with the aid of the medical device; simultaneously recording movement-related measured data with the aid of the medical device; determining at least one item of movement information relating to at least one movement operation of the patient and/or in the body of the patient by evaluating at least a portion of the recorded measured data of high temporal resolution on the part of a computing device of the medical device; and adapting at least one item of attenuation correction information available for the computing device and serving for reconstructing the nuclear medicine measured data, doing so as a function of the at least one determined item of movement information.

摘要翻译： 公开了一种用于记录患者的测量数据的方法，同时考虑到通过设计用于记录运动相关测量数据的医疗设备，特别是高时间分辨率的测量数据和/或可测量数据的测量数据， 借助于成像方法和/或通过至少一个传感器元件，以及用于记录核医学测量数据，特别是用于记录较低时间分辨率的内插关于移动操作。 在至少一个实施例中，该方法包括借助医疗装置记录核医学测量数据; 借助医疗设备同时记录运动相关测量数据; 通过在计算设备的一部分上评估所记录的高时间分辨率的测量数据的至少一部分来确定与患者的至少一个移动操作和/或患者身体有关的至少一个移动信息项 医疗器械; 以及修改可用于所述计算设备的至少一项衰减校正信息，并且用于重构所述核医学测量数据，作为所述至少一个确定的运动信息项的函数。

公开(公告)号：US20090037130A1

公开(公告)日：2009-02-05

申请号：US12219610

申请日：2008-07-24

申请人： Thorsten Feiweier ,  Ralf Ladebeck ,  Diana Martin ,  Hartwig Newiger ,  Josef Pfeuffer ,  Michael Szimtenings ,  Harald Werthner

发明人： Thorsten Feiweier ,  Ralf Ladebeck ,  Diana Martin ,  Hartwig Newiger ,  Josef Pfeuffer ,  Michael Szimtenings ,  Harald Werthner

IPC分类号： G01R35/00

CPC分类号： A61B6/032 ,  A61B5/11 ,  A61B5/7285 ,  A61B6/037 ,  A61B6/5247 ,  A61B6/541 ,  A61B8/00 ,  A61B8/4416 ,  A61B90/36 ,  A61B2090/364 ,  G06F19/00

摘要： A method is disclosed for recording measured data from a patient by taking movements into account by use of a medical device designed both for recording motion-related measured data, in particular measured data with a high temporal resolution and/or measured data which can be interpolated with regard to movements, using an imaging method and/or by use of at least one sensor element and for recording nuclear medicine measured data, in particular with a relatively low temporal resolution. In at least one embodiment, the method includes recording nuclear medicine measured data by use of the medical device; simultaneously recording motion-related measured data by use of the medical device; determining at least one motion information item relating to at least one movement of the patient and/or at least one movement inside the body of the patient during the ongoing measured data recording by evaluating at least a portion of the previously recorded motion-related measured data by use of a computational device of the medical device; and carrying out motion correction for at least a portion of the nuclear medicine measured data in real-time by use of the computational device in parallel with recording the measured data depending on the at least one determined motion information item.

摘要翻译： 公开了一种用于通过使用设计用于记录运动相关测量数据的医疗装置，特别是具有高时间分辨率的测量数据和/或可被内插的测量数据来考虑来自患者的测量数据来记录测量数据的方法 关于运动，使用成像方法和/或通过使用至少一个传感器元件并且用于记录核医学测量数据，特别是具有相对低的时间分辨率。 在至少一个实施例中，该方法包括使用医疗装置记录核医学测量数据; 通过使用医疗装置同时记录运动相关测量数据; 在正在进行的测量数据记录期间，通过评估先前记录的运动相关测量数据的至少一部分来确定与患者的至少一个运动和/或患者体内的至少一个运动相关的至少一个运动信息项 通过使用医疗装置的计算装置; 以及根据所述至少一个所确定的运动信息项，通过使用所述计算装置与记录所述测量数据并行地对所述核医学测量数据的至少一部分进行实时运动校正。

公开(公告)号：US09636422B2

公开(公告)日：2017-05-02

申请号：US12219609

申请日：2008-07-24

申请人： Thorsten Feiweier ,  Diana Martin ,  Günther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

发明人： Thorsten Feiweier ,  Diana Martin ,  Günther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

IPC分类号： A61K49/00 ,  A61B6/03 ,  A61B6/00 ,  A61B5/00

CPC分类号： A61K49/0004 ,  A61B5/4064 ,  A61B5/4088 ,  A61B6/037 ,  A61B6/5247

摘要： A computerized method is disclosed for detecting a brain region with neurodegenerative change and also a brain region with vascular change in the brain of a patient and also an imaging arrangement suitable for this. In at least one embodiment, the method includes recording a first data record of the brain via positron emission tomography and a second data record of the brain via magnetic resonance imaging; reconstructing a PET image from the first data record and an MRI image from the second data record; identifying evidence for a brain region with vascular change in the MRI image; segmenting the MRI image into gray matter and white matter; identifying a brain region with neurodegenerative change in the PET image; and superposing the PET image and the segmented MRI image to determine whether the brain region with neurodegenerative change is present in gray matter or in white matter, the recording of the first data record and the second data record being carried out in quick succession without repositioning the patient or is even carried out simultaneously.

公开(公告)号：US20090018431A1

公开(公告)日：2009-01-15

申请号：US12216293

申请日：2008-07-02

申请人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

发明人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

IPC分类号： A61B5/05

CPC分类号： G01R33/481 ,  A61B5/0035 ,  A61B5/04008 ,  A61B5/4094 ,  A61B6/037 ,  A61B6/501 ,  A61B6/5247

摘要： A method and an apparatus are disclosed for imaging functional processes in the brain. In order to be able to correlate the results of MEG examinations with anatomical information and metabolic data, a positron emission tomography measurement is recorded in at least one embodiment by at least one radiation detector, a magnetic resonance imaging measurement is recorded by a coil and a radio-frequency antenna device and a magnetoencephalography measurement is recorded by a plurality of magnetic field sensors, the positron emission tomography measurement and the magnetic resonance imaging measurement being substantially undertaken at the same time, so that the records of the positron emission tomography measurement and the magnetic resonance tomography measurement are isocentric. In at least one embodiment, an evaluation apparatus is provided for carrying out a spatial correlation between the magnetoencephalography measurement and the magnetic resonance imaging measurement, so that registration between the magnetoencephalography measurement and the positron emission tomography measurement results.

摘要翻译： 公开了一种用于成像脑中的功能过程的方法和装置。 为了能够将MEG检查的结果与解剖信息和代谢数据相关联，在至少一个实施例中通过至少一个辐射检测器记录正电子发射断层摄影测量，磁共振成像测量由线圈和 射频天线装置和脑磁图测量由多个磁场传感器记录，正电子发射断层摄影测量和磁共振成像测量基本上同时进行，使得正电子发射断层摄影测量和 磁共振断层扫描测量是同中心的。 在至少一个实施例中，提供了一种用于执行脑磁图测量和磁共振成像测量之间的空间相关性的评估装置，从而导致脑磁图测量与正电子发射断层摄影测量之间的配准。

公开(公告)号：US20090005678A1

公开(公告)日：2009-01-01

申请号：US12213745

申请日：2008-06-24

申请人： Kristin Schmiedehausen ,  Gunther Platsch ,  Thorsten Feiweier ,  Diana Martin ,  Sebastian Schmidt ,  Michael Szimtenings

发明人： Kristin Schmiedehausen ,  Gunther Platsch ,  Thorsten Feiweier ,  Diana Martin ,  Sebastian Schmidt ,  Michael Szimtenings

IPC分类号： A61B6/03

CPC分类号： A61B6/501 ,  A61B6/037 ,  A61B6/507 ,  A61B34/10 ,  A61B90/36 ,  A61B2090/364 ,  A61B2090/374

摘要： A computer-implemented method is disclosed for determining and displaying an access corridor to a target area in the brain of a patient, as well as an imaging arrangement suited to this. In at least one embodiment, the method includes a) generating a first image of the brain via positron emission tomography, b) discriminating the target area relative to its surroundings via electronic image processing, c) generating a second image of the brain via magnetic resonance imaging while acquiring at least one anatomical structure, d) generating a third image of the brain via an imaging method displaying physiological processes for identifying at least one functional area of the brain that must not be injured in any circumstances, e) determining an access corridor to the target area while omitting the at least one functional area of the brain, and f) generating and displaying a fourth image of the brain in which the target area, the at least one functional area of the brain, the at least one anatomical structure and the access corridor are displayed, wherein steps a) to d) are carried out, one after another in quick succession, in a single frame of reference without repositioning the patient, or are even carried out simultaneously.

摘要翻译： 公开了一种计算机实现的方法，用于确定和显示患者脑中的目标区域的通道走廊以及适合于此的成像装置。 在至少一个实施例中，该方法包括：a）通过正电子发射断层摄影术产生脑的第一图像，b）通过电子图像处理区分相对于其周围的目标区域，c）通过磁共振产生大脑的第二图像 成像，同时获取至少一个解剖结构，d）通过显示生理过程的成像方法产生大脑的第三图像，用于识别在任何情况下不得受伤的脑的至少一个功能区域，e）确定通路走廊 到目标区域，同时省略脑的至少一个功能区域，以及f）产生和显示脑的第四图像，其中目标区域，脑的至少一个功能区域，至少一个解剖结构 并且显示进入通道，其中步骤a）至d）在一个单独的参考框架中以快速连续的方式相继地执行而不重新定位 或者甚至同时进行。

公开(公告)号：US20090030304A1

公开(公告)日：2009-01-29

申请号：US12219609

申请日：2008-07-24

申请人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

发明人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

IPC分类号： A61B5/055

CPC分类号： A61K49/0004 ,  A61B5/4064 ,  A61B5/4088 ,  A61B6/037 ,  A61B6/5247

摘要： A computerized method is disclosed for detecting a brain region with neurodegenerative change and also a brain region with vascular change in the brain of a patient and also an imaging arrangement suitable for this. In at least one embodiment, the method includes recording a first data record of the brain via positron emission tomography and a second data record of the brain via magnetic resonance imaging; reconstructing a PET image from the first data record and an MRI image from the second data record; identifying evidence for a brain region with vascular change in the MRI image; segmenting the MRI image into gray matter and white matter; identifying a brain region with neurodegenerative change in the PET image; and superposing the PET image and the segmented MRI image to determine whether the brain region with neurodegenerative change is present in gray matter or in white matter, the recording of the first data record and the second data record being carried out in quick succession without repositioning the patient or is even carried out simultaneously.

摘要翻译： 公开了一种用于检测具有神经变性变化的脑区域以及患者脑部血管变化的脑区域的计算机化方法，以及适合于此的成像装置。 在至少一个实施例中，该方法包括通过正电子发射断层摄影和脑的第二数据记录经由磁共振成像记录脑的第一数据记录; 从第一数据记录重建PET图像和从第二数据记录重建MRI图像; 识别MRI图像中具有血管变化的脑区域的证据; 将MRI图像分割成灰质和白质; 识别PET图像中具有神经变性变化的脑区域; 并叠加PET图像和分割的MRI图像，以确定具有神经变性变化的脑区域是否存在于灰质物质或白质中，第一数据记录和第二数据记录的记录被快速连续进行而不重新定位 病人或甚至同时进行。

公开(公告)号：US08467845B2

公开(公告)日：2013-06-18

申请号：US12153487

申请日：2008-05-20

申请人： Diana Martin ,  Thorsten Feiweier ,  Günther Platsch ,  Kristin Schmiedehausen ,  Sebastian Schmidt ,  Michael Szimtenings

发明人： Diana Martin ,  Thorsten Feiweier ,  Günther Platsch ,  Kristin Schmiedehausen ,  Sebastian Schmidt ,  Michael Szimtenings

IPC分类号： A61B5/05

CPC分类号： G01R33/481 ,  A61B6/501 ,  A61B6/5247 ,  A61B2090/364 ,  G01R33/4806

摘要： A method is disclosed for data acquisition and/or data evaluation during a functional brain examination with the aid of a combined magnetic resonance/PET unit. In at least one embodiment, functional image data of the brain are acquired in at least two activity states with the aid of both modalities. Further, magnetic resonance image data and PET image data are acquired within time windows determined by the activity states, the acquisition mode and/or the image data being synchronized as a function of a timing of stimulations determining the activity states.

摘要翻译： 公开了一种借助于组合磁共振/ PET单元在功能性脑部检查期间进行数据采集和/或数据评估的方法。 在至少一个实施例中，借助于两种模式在至少两个活动状态中获取大脑的功能图像数据。 此外，在由活动状态确定的时间窗内获取磁共振图像数据和PET图像数据，获取模式和/或图像数据作为确定活动状态的刺激的定时的函数被同步。

公开(公告)号：US20090048507A1

公开(公告)日：2009-02-19

申请号：US12222210

申请日：2008-08-05

申请人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

发明人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

IPC分类号： A61B5/055 ,  A61B5/0476 ,  G01V3/00 ,  A61B6/00

CPC分类号： A61B6/037 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/4094 ,  A61B6/032 ,  A61B6/501 ,  A61B6/5247 ,  G06T7/30

摘要： A method and an apparatus for imaging functional and electrical activities of the brain are disclosed. In order to allow improved relative positional determination of the epileptogenic focus with reference to the EEG electrodes, a positron emission tomography measurement using at least one radiation detector, and a magnetic resonance imaging measurement using at least one coil for generating a basic magnetic field, at least one gradient coil and a radio-frequency antenna device are undertaken in at least one embodiment. In addition, in at least one embodiment an electroencephalography measurement using a plurality of electrodes for acquiring spatial and temporal changes of the electrical activities of the brain and a computed tomography measurement using at least one x-ray source and at least one x-ray detector are carried out. By way of an evaluation apparatus in at least one embodiment, a spatial correlation between the computed tomography measurement and the magnetic resonance imaging measurement is undertaken, so as to result in registration between the electroencephalography measurement and the positron emission tomography measurement.

摘要翻译： 公开了一种用于成像大脑的功能和电活动的方法和装置。 为了允许参考EEG电极改进癫痫发生焦点的相对位置确定，使用至少一个辐射检测器的正电子发射断层摄影测量和使用至少一个线圈产生基本磁场的磁共振成像测量，在 至少一个实施例中进行至少一个梯度线圈和射频天线装置。 另外，在至少一个实施例中，使用多个电极获取脑的电活动的空间和时间变化以及使用至少一个X射线源和至少一个X射线检测器的计算机断层摄影测量的脑电图测量 被执行。 通过至少一个实施例中的评估装置，进行计算机断层摄影测量和磁共振成像测量之间的空间相关性，以便导致脑电图测量与正电子发射断层摄影测量之间的对准。