公开(公告)号：US08007841B2

公开(公告)日：2011-08-30

申请号：US11857672

申请日：2007-09-19

申请人： Thumplasseril V. John ,  Markus A. Eckert ,  Mark L. Dewis ,  Jan Herman Colstee ,  Neil C. da Costa

发明人： Thumplasseril V. John ,  Markus A. Eckert ,  Mark L. Dewis ,  Jan Herman Colstee ,  Neil C. da Costa

IPC分类号： A61K36/67 ,  A23L2/56

CPC分类号： C07D295/185 ,  A01N65/08 ,  A23G3/346 ,  A23G4/06 ,  A23G4/068 ,  A23G2200/00 ,  A23G2200/14 ,  A23L2/56 ,  A23L3/3472 ,  A23L27/11 ,  A23L27/12 ,  A23L27/2028 ,  A23L27/2054 ,  A23L33/105 ,  A23L33/12 ,  A23L33/175 ,  A61K8/42 ,  A61K8/4913 ,  A61K8/4926 ,  A61K2800/242 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q13/00 ,  A61Q17/005 ,  A61Q19/00 ,  C07C233/09

摘要： Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula —(CH2)n—, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

摘要翻译： 描述了根据以下结构定义的至少四种烷酰胺的混合物：其中R表示C 1 -C 2正烷基; R 1是2-甲基-1-丙基，R 2是氢，或者R 1和R 2一起是具有式 - （CH 2）n - 的部分，其中n是4或5，或者含有大量浓度的这种混合物的组合物 根据新颖的方法：（a）提取一种Pi子种，Pi um或Pi子的地面基本干燥的果实; （b）天然产物形成合成; 或（c）合成产物形成合成。 还描述了如此形成的产品用于在消耗材料和/或口腔和/或哺乳动物表皮中或/或在哺乳动物表皮上增强，增强或赋予芳香，味觉，化学疗效和/或抗菌作用的用途。

公开(公告)号：US08007840B2

公开(公告)日：2011-08-30

申请号：US11857587

申请日：2007-09-19

申请人： Thumplasseril V. John ,  Markus A. Eckert ,  Mark L. Dewis ,  Jan Herman Colstee ,  Neil C. da Costa

发明人： Thumplasseril V. John ,  Markus A. Eckert ,  Mark L. Dewis ,  Jan Herman Colstee ,  Neil C. da Costa

IPC分类号： A61K36/67 ,  A23L2/56

CPC分类号： C07D295/185 ,  A01N65/08 ,  A23G3/346 ,  A23G4/06 ,  A23G4/068 ,  A23G2200/00 ,  A23G2200/14 ,  A23L2/56 ,  A23L3/3472 ,  A23L27/11 ,  A23L27/12 ,  A23L27/2028 ,  A23L27/2054 ,  A23L33/105 ,  A23L33/12 ,  A23L33/175 ,  A61K8/42 ,  A61K8/4913 ,  A61K8/4926 ,  A61K2800/242 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q13/00 ,  A61Q17/005 ,  A61Q19/00 ,  C07C233/09

摘要： Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula —(CH2)n—, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

公开(公告)号：US08007839B2

公开(公告)日：2011-08-30

申请号：US10678558

申请日：2003-10-03

申请人： Thumplasseril V. John ,  Markus A. Eckert ,  Mark L. Dewis ,  Jan Herman Colstee ,  Neil C. da Costa

发明人： Thumplasseril V. John ,  Markus A. Eckert ,  Mark L. Dewis ,  Jan Herman Colstee ,  Neil C. da Costa

IPC分类号： A61K36/67 ,  A23L2/56

CPC分类号： C07D295/185 ,  A01N65/08 ,  A23G3/346 ,  A23G4/06 ,  A23G4/068 ,  A23G2200/00 ,  A23G2200/14 ,  A23L2/56 ,  A23L3/3472 ,  A23L27/11 ,  A23L27/12 ,  A23L27/2028 ,  A23L27/2054 ,  A23L33/105 ,  A23L33/12 ,  A23L33/175 ,  A61K8/42 ,  A61K8/4913 ,  A61K8/4926 ,  A61K2800/242 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q13/00 ,  A61Q17/005 ,  A61Q19/00 ,  C07C233/09

摘要： Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula —(CH2)n— wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

摘要翻译： 描述了根据以下结构定义的至少四种烷酰胺的混合物：其中R表示C 1 -C 2正烷基; R 1是2-甲基-1-丙基，R 2是氢，或者R 1和R 2一起是具有式 - （CH 2）n - 的部分，其中n是4或5，或包含基本浓度的这种混合物的组合物， 以新颖的方法：（a）提取一种Pi子种，Pi um n或琵琶鹦鹉之一的基本干燥的果实; （b）天然产物形成合成; 或（c）合成产物形成合成。 还描述了如此形成的产品用于在消耗材料和/或口腔和/或哺乳动物表皮中或/或在哺乳动物表皮上增加，增强或赋予芳香，味觉，化学疗效和/或抗菌作用的用途。