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1.发明授权Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof 有权共轭二烯酰胺，其制备方法，含有它们的组合物及其用途公开(公告)号：US08007841B2
公开(公告)日：2011-08-30
申请号：US11857672
申请日：2007-09-19
申请人： Thumplasseril V. John , Markus A. Eckert , Mark L. Dewis , Jan Herman Colstee , Neil C. da Costa
发明人： Thumplasseril V. John , Markus A. Eckert , Mark L. Dewis , Jan Herman Colstee , Neil C. da Costa
CPC分类号： C07D295/185 , A01N65/08 , A23G3/346 , A23G4/06 , A23G4/068 , A23G2200/00 , A23G2200/14 , A23L2/56 , A23L3/3472 , A23L27/11 , A23L27/12 , A23L27/2028 , A23L27/2054 , A23L33/105 , A23L33/12 , A23L33/175 , A61K8/42 , A61K8/4913 , A61K8/4926 , A61K2800/242 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q17/005 , A61Q19/00 , C07C233/09
摘要： Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula —(CH2)n—, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
摘要翻译： 描述了根据以下结构定义的至少四种烷酰胺的混合物：其中R表示C 1 -C 2正烷基; R 1是2-甲基-1-丙基，R 2是氢，或者R 1和R 2一起是具有式 - （CH 2）n - 的部分，其中n是4或5，或者含有大量浓度的这种混合物的组合物 根据新颖的方法：（a）提取一种Pi子种，Pi um或Pi子的地面基本干燥的果实; （b）天然产物形成合成; 或（c）合成产物形成合成。 还描述了如此形成的产品用于在消耗材料和/或口腔和/或哺乳动物表皮中或/或在哺乳动物表皮上增强，增强或赋予芳香，味觉，化学疗效和/或抗菌作用的用途。
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2.发明授权公开(公告)号：US07025997B2
公开(公告)日：2006-04-11
申请号：US10671411
申请日：2003-09-24
IPC分类号： A61K35/78
CPC分类号： A61K8/97 , A23L27/11 , A61K8/37 , A61K2800/244 , A61Q19/00
摘要： The present invention relates to plant extracts containing a monomenthyl succinate for use as a coolant in food and non-food products. Methods for isolating the plant extracts are also provided.
摘要翻译： 本发明涉及含有用作食品和非食品中的冷却剂的琥珀酸单薄荷酯的植物提取物。 还提供了分离植物提取物的方法。
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公开(公告)号：US20110280812A1
公开(公告)日：2011-11-17
申请号：US12778622
申请日：2010-05-12
申请人： Karunananda Bombuwala , Adam Jan Janczuk , Thumplasseril V. John , Kenneth Kraut , Zhihua Liu , Neelima Mannava , Hou Wu , Ying Yang
发明人： Karunananda Bombuwala , Adam Jan Janczuk , Thumplasseril V. John , Kenneth Kraut , Zhihua Liu , Neelima Mannava , Hou Wu , Ying Yang
CPC分类号： C07C233/09 , A23L27/202 , A23L27/88
摘要： The present invention has discovered that amide compounds represented by Formula I set forth below have unexpected and advantageous flavor enhancement and modification properties: wherein R and R′ is independently selected from the group consisting of H and C1-C10 linear, branched, or cyclic alkyl, alkenyl, alkynyl or aromactic groups. Thus, the amide compounds of the present invention can be used to enhance or modify the flavor of orally consumable compositions, such as foodstuff, chewing gums, dental and oral hygiene products, and medicinal products.
摘要翻译： 本发明已经发现，下述式I所示的酰胺化合物具有出人意料的且有利的风味增强和改性特性：其中R和R'独立地选自H和C 1 -C 10直链，支链或环状烷基 ，烯基，炔基或芳族基团。 因此，本发明的酰胺化合物可以用于增强或改变口腔消耗性组合物如食品，口香糖，牙科和口腔卫生用品以及药用产品的风味。
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4.发明授权公开(公告)号：US08007840B2
公开(公告)日：2011-08-30
申请号：US11857587
申请日：2007-09-19
申请人： Thumplasseril V. John , Markus A. Eckert , Mark L. Dewis , Jan Herman Colstee , Neil C. da Costa
发明人： Thumplasseril V. John , Markus A. Eckert , Mark L. Dewis , Jan Herman Colstee , Neil C. da Costa
CPC分类号： C07D295/185 , A01N65/08 , A23G3/346 , A23G4/06 , A23G4/068 , A23G2200/00 , A23G2200/14 , A23L2/56 , A23L3/3472 , A23L27/11 , A23L27/12 , A23L27/2028 , A23L27/2054 , A23L33/105 , A23L33/12 , A23L33/175 , A61K8/42 , A61K8/4913 , A61K8/4926 , A61K2800/242 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q17/005 , A61Q19/00 , C07C233/09
摘要： Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula —(CH2)n—, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
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5.发明授权Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof 有权共轭二烯酰胺，其制备方法，含有它们的组合物及其用途公开(公告)号：US08007839B2
公开(公告)日：2011-08-30
申请号：US10678558
申请日：2003-10-03
申请人： Thumplasseril V. John , Markus A. Eckert , Mark L. Dewis , Jan Herman Colstee , Neil C. da Costa
发明人： Thumplasseril V. John , Markus A. Eckert , Mark L. Dewis , Jan Herman Colstee , Neil C. da Costa
CPC分类号： C07D295/185 , A01N65/08 , A23G3/346 , A23G4/06 , A23G4/068 , A23G2200/00 , A23G2200/14 , A23L2/56 , A23L3/3472 , A23L27/11 , A23L27/12 , A23L27/2028 , A23L27/2054 , A23L33/105 , A23L33/12 , A23L33/175 , A61K8/42 , A61K8/4913 , A61K8/4926 , A61K2800/242 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q17/005 , A61Q19/00 , C07C233/09
摘要： Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula —(CH2)n— wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
摘要翻译： 描述了根据以下结构定义的至少四种烷酰胺的混合物：其中R表示C 1 -C 2正烷基; R 1是2-甲基-1-丙基，R 2是氢，或者R 1和R 2一起是具有式 - （CH 2）n - 的部分，其中n是4或5，或包含基本浓度的这种混合物的组合物， 以新颖的方法：（a）提取一种Pi子种，Pi um n或琵琶鹦鹉之一的基本干燥的果实; （b）天然产物形成合成; 或（c）合成产物形成合成。 还描述了如此形成的产品用于在消耗材料和/或口腔和/或哺乳动物表皮中或/或在哺乳动物表皮上增加，增强或赋予芳香，味觉，化学疗效和/或抗菌作用的用途。
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6.发明授权Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof 有权共轭二烯酰胺，其制备方法，含有它们的组合物及其用途公开(公告)号：US07329767B2
公开(公告)日：2008-02-12
申请号：US10919631
申请日：2004-08-17
申请人： Mark L. Dewis , Thumplasseril V. John , Markus A. Eckert , Jan Herman Colstee , Neil C. Da Costa , Tao Pei
发明人： Mark L. Dewis , Thumplasseril V. John , Markus A. Eckert , Jan Herman Colstee , Neil C. Da Costa , Tao Pei
IPC分类号： C07C233/00
CPC分类号： A23G3/346 , A01N37/18 , A01N65/08 , A23G4/06 , A23G4/068 , A23G2200/00 , A23G2200/14 , A23L2/56 , A23L27/2028 , A23L27/2054 , A23L33/175 , A61K8/42 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q17/005 , C07C233/09 , C07D295/185 , C11B9/0019 , C11B9/0092 , A01N2300/00
摘要： Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
摘要翻译： 描述了根据以下结构定义的至少四种烷酰胺的混合物：其中R表示C 1 -C 2烷基; R 1是2-甲基-1-丙基，R 2是氢，或R 1和R 2是氢， 一起是具有下式的部分，其中n为4或5，或包含基本浓度的这种混合物的组合物，其按照新方法制备：（a）提取per皮种之一的干燥果实（Piper longum Linn 或Piper peepuloides; （b）天然产物形成合成; 或（c）合成产物形成合成。 还描述了如此形成的产品用于在消耗材料和/或口腔和/或哺乳动物表皮中或/或在哺乳动物表皮上增强，增强或赋予芳香，味觉，化学疗效和/或抗菌作用的用途。
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