摘要:
The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要:
The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要:
The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要:
The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要:
The invention is directed to acylhydrazones compounds of Formula I: where R1, R2 and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要:
An increased precision position sensor comprises a first magnetic field sensing device; a second magnetic field sensing device; and a processor, the processor further comprising a calibrator; a mathematical model to predict the magnetic field at a given position relative to the object; and an estimator algorithm to compare the measured magnetic field within the predicted magnetic field, thereby calculating the most likely position of the position sensor relative to the magnetic object. A position sensor in accordance with the invention is capable of locating the axis of a cylindrical magnetic object to within ±0.5 mm through 70 mm thick aluminium, and is expected to find application, in the aerospace industry, or other industries where high precision during manufacture is required. The invention may be conveniently embodied in a portable, handheld device.
摘要:
An intrinsically safe battery circuit for connection between a battery and a load, such as a hand held transceiver, referred to as "HT's". The circuit includes a minor current path through a switching transistor and a major current path through a SCR. The circuit is a hybrid circuit which includes an integrated circuit timer which provides a delay in establishing the major current path subsequent to the minor current path being established, and mounts on a small printed circuit board.
摘要:
A method for calibrating a first co-ordinate frame of a robot and effector in a second frame of reference of a sensor when the sensor is substantially rigidly attached to the robot and effector, including the steps of measuring first positions of a plurality of first light sources relative to the sensor, with the first positions corresponding to a first absolute position of the robot and effector, moving the robot and effector, measuring second positions of the plurality of first light sources, which second positions correspond to the desired second absolute position of the robot and effector and the sensor, repeating the measurement of and movement from the first to second positions so as to provide at least two sets of measurements of first and second positions corresponding to at least two movements, each of which at least two movements is a known, unique transform, combining the at least two sets of measurements of first and second positions so as to calibrate the first co-ordinate frame in the second frame of reference.
摘要:
Printing priority is ascertained according to a bidding process that allows users to submit bids along with their print jobs. The printer orders the print jobs from highest to lowest bid. This allows individual users to determine the importance of each print job. If urgent, the user can submit a higher bid to place the print job at the top of the queue ahead of print jobs deemed less important by the users that submitted them. Prioritizing the print jobs according to user submitted bids allows the printer to better reflect the urgencies and printing needs of all users.
摘要:
A polyethylene garment protector, extensively used by garment manufacturers to protect garments in transport to and from various facilities such as, factories, distribution centers, and retail establishments. The garment protector is also commonly used by garment pressers or cleaners for the delivery or storage of pressed or cleaned garments mounted on conventional garment hangers. Furthermore, the polyethylene garment protector can also be used to enclose other textiles or goods that may be stored, shipped and/or sold in hanging form. The polyethylene garment protector is provided with at least one zone of weakness on either the front side, back side or both sides of such garment protectors, along which the garment protector may be severed to facilitate its removal so that the enclosed garment is not wrinkled or mussed. Essentially, the zone of weakness provides tear lines upon which the envelope may be opened to facilitate separating the protector and the enclosed garment. The zone of weakness may include minute perforations, which can vary in size and shape. Furthermore, the material of which the garment protector is made may also be partially but not completely severed along the linear zone of weakness. Alternatively, the zone of weakness may comprise a strip of thinner and less resilient material than the adjacent material from which the envelope is made, which can be easily torn.