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    Extracellular matrix-binding proteins from Staphylococcus aureus
    4.
    发明申请
    Extracellular matrix-binding proteins from Staphylococcus aureus 审中-公开
    来自金黄色葡萄球菌的细胞外基质结合蛋白

    公开(公告)号：US20050026170A1

    公开(公告)日：2005-02-03

    申请号：US10744616

    申请日：2003-12-24

    申请人： Joseph Patti ,  Timothy Foster ,  Elisabet Josefsson ,  Deidre Eidhin ,  Magnus Hook ,  Samuel Perkins

    发明人： Joseph Patti ,  Timothy Foster ,  Elisabet Josefsson ,  Deidre Eidhin ,  Magnus Hook ,  Samuel Perkins

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/31 ,  C12Q1/68 ,  C07K16/40

    CPC分类号： G01N33/56938 ,  A61K38/00 ,  A61K39/00 ,  C07K14/31 ,  G01N2469/00 ,  Y10S435/975 ,  Y10S530/81 ,  Y10S530/825

    摘要： Isolated extracellular matrix-binding proteins, designated ClfB, SdrC, SdrD and SdrE, and their corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials. ClfB is a cell-wall associated protein having a predicted molecular weight of approximately 88 kDa and an apparent molecular weight of approximately 124 kDa, which binds both soluble and immobilized fibrinogen. ClfB binds both the alpha and beta chains of fibrinogen and acts as a clumping factor. SdrC, SdrD and SdrE are cell-wall associated proteins that exhibit cation-dependent ligand binding to the extracellular matrix. It has been discovered that in the A region of SdrC, SdrD, SdrE, ClfA and ClfB, there is a highly conserved amino acid sequence that can be used to derive a consensus motif of TYTFTDYVD.

    摘要翻译： 描述了分离的细胞外基质结合蛋白，命名为ClfB，SdrC，SdrD和SdrE，以及它们相应的氨基酸和核酸序列和基序。 蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。 此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。 特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。 ClfB是具有约88kDa的预测分子量和约124kDa的表观分子量的细胞壁相关蛋白，其结合可溶性和固定的纤维蛋白原。 ClfB结合纤维蛋白原的α链和β链，并作为聚集因子。 SdrC，SdrD和SdrE是表现出阳离子依赖性配体结合细胞外基质的细胞壁相关蛋白。 已经发现，在SdrC，SdrD，SdrE，ClfA和ClfB的A区域中，存在可用于得到TYTFTDYVD的共有基序的高度保守的氨基酸序列。

    SDRD protein from Staphylococcus aureus and diagnostic kits including same
    5.
    发明授权
    SDRD protein from Staphylococcus aureus and diagnostic kits including same 有权
    来自金黄色葡萄球菌的SDRD蛋白和包括其的诊断试剂盒

    公开(公告)号：US07834151B2

    公开(公告)日：2010-11-16

    申请号：US12546289

    申请日：2009-08-24

    申请人： Joseph M. Patti ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A. O. Hook ,  Samuel E. Perkins

    发明人： Joseph M. Patti ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A. O. Hook ,  Samuel E. Perkins

    IPC分类号： C07K1/00

    CPC分类号： G01N33/56938 ,  A61K38/00 ,  A61K39/00 ,  C07K14/31 ,  G01N2469/00 ,  Y10S435/975 ,  Y10S530/81 ,  Y10S530/825

    摘要： An isolated extracellular matrix-binding protein, designated as SdrD and its corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.

    摘要翻译： 描述了分离的细胞外基质结合蛋白，称为SdrD及其相应的氨基酸和核酸序列和基序。 蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。 此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。 特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。

    SDRE protein from Staphylococcus aureus and diagnostic kits including same
    6.
    发明授权
    SDRE protein from Staphylococcus aureus and diagnostic kits including same 有权
    来自金黄色葡萄球菌的SDRE蛋白和包括其的诊断试剂盒

    公开(公告)号：US07855272B2

    公开(公告)日：2010-12-21

    申请号：US12546322

    申请日：2009-08-24

    申请人： Joseph M. Patti ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A. O. Hook ,  Samuel E. Perkins

    发明人： Joseph M. Patti ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A. O. Hook ,  Samuel E. Perkins

    IPC分类号： C07K1/00

    CPC分类号： G01N33/56938 ,  A61K38/00 ,  A61K39/00 ,  C07K14/31 ,  G01N2469/00 ,  Y10S435/975 ,  Y10S530/81 ,  Y10S530/825

    摘要： An isolated extracellular matrix-binding protein, designated as SdrE and its corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.

    摘要翻译： 描述了分离的细胞外基质结合蛋白，命名为SdrE及其相应的氨基酸和核酸序列和基序。 蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。 此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。 特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。

    EXTRACELLULAR MATRIX-BINDING PROTEINS FROM STAPHYLOCOCCUS AUREUS
    7.
    发明申请
    EXTRACELLULAR MATRIX-BINDING PROTEINS FROM STAPHYLOCOCCUS AUREUS 有权
    来自ST FROM US US US US US US US US US US US US US US US US US US US US US

    公开(公告)号：US20100113349A1

    公开(公告)日：2010-05-06

    申请号：US12546322

    申请日：2009-08-24

    申请人： Joseph M. PATTI ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A.O. Hook ,  Samuel E. Perkins

    发明人： Joseph M. PATTI ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A.O. Hook ,  Samuel E. Perkins

    IPC分类号： A61K38/16 ,  C07K14/315 ,  G01N33/566

    CPC分类号： G01N33/56938 ,  A61K38/00 ,  A61K39/00 ,  C07K14/31 ,  G01N2469/00 ,  Y10S435/975 ,  Y10S530/81 ,  Y10S530/825

    摘要： An isolated extracellular matrix-binding protein, designated as SdrE and its corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.

    摘要翻译： 描述了分离的细胞外基质结合蛋白，命名为SdrE及其相应的氨基酸和核酸序列和基序。 蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。 此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。 特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。

    EXTRACELLULAR MATRIX-BINDING PROTEINS FROM STAPHYLOCOCCUS AUREUS
    8.
    发明申请
    EXTRACELLULAR MATRIX-BINDING PROTEINS FROM STAPHYLOCOCCUS AUREUS 有权
    来自ST FROM US US US US US US US US US US US US US US US US US US US US US

    公开(公告)号：US20100081616A1

    公开(公告)日：2010-04-01

    申请号：US12546289

    申请日：2009-08-24

    申请人： Joseph M. Patti ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A.O. Hook ,  Samuel E. Perkins

    发明人： Joseph M. Patti ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A.O. Hook ,  Samuel E. Perkins

    IPC分类号： A61K38/16 ,  C07K14/31 ,  G01N33/569

    CPC分类号： G01N33/56938 ,  A61K38/00 ,  A61K39/00 ,  C07K14/31 ,  G01N2469/00 ,  Y10S435/975 ,  Y10S530/81 ,  Y10S530/825

    摘要： An isolated extracellular matrix-binding protein, designated as SdrD and its corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.

    摘要翻译： 描述了分离的细胞外基质结合蛋白，称为SdrD及其相应的氨基酸和核酸序列和基序。 蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。 此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。 特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。

    Extracellular matrix-binding proteins from Staphylococcus aureus
    9.
    发明授权
    Extracellular matrix-binding proteins from Staphylococcus aureus 有权
    来自金黄色葡萄球菌的细胞外基质结合蛋白

    公开(公告)号：US07381793B2

    公开(公告)日：2008-06-03

    申请号：US10744672

    申请日：2003-12-24

    申请人： Joseph M. Patti ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A. O. Hook ,  Samuel E. Perkins

    发明人： Joseph M. Patti ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A. O. Hook ,  Samuel E. Perkins

    IPC分类号： C07K1/00

    CPC分类号： G01N33/56938 ,  A61K38/00 ,  A61K39/00 ,  C07K14/31 ,  G01N2469/00 ,  Y10S435/975 ,  Y10S530/81 ,  Y10S530/825

    摘要： Isolated extracellular matrix-binding proteins, designated ClfB, SdrC, SdrD and SdrE, and their corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.ClfB is a cell-wall associated protein having a predicted molecular weight of approximately 88 kDa and an apparent molecular weight of approximately 124 kDa, which binds both soluble and immobilized fibrinogen. ClfB binds both the alpha and beta chains of fibrinogen and acts as a clumping factor. SdrC, SdrD and SdrE are cell-wall associated proteins that exhibit cation-dependent ligand binding to the extracellular matrix. It has been discovered that in the A region of SdrC, SdrD, SdrE, ClfA and ClfB, there is a highly conserved amino acid sequence that can be used to derive a consensus motif of TYTFTDYVD.

    摘要翻译： 描述了分离的细胞外基质结合蛋白，命名为ClfB，SdrC，SdrD和SdrE，以及它们相应的氨基酸和核酸序列和基序。 蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。 此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。 特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。 ClfB是具有约88kDa的预测分子量和约124kDa的表观分子量的细胞壁相关蛋白，其结合可溶性和固定的纤维蛋白原。 ClfB结合纤维蛋白原的α链和β链，并作为聚集因子。 SdrC，SdrD和SdrE是表现出阳离子依赖性配体结合细胞外基质的细胞壁相关蛋白。 已经发现，在SdrC，SdrD，SdrE，ClfA和ClfB的A区域中，存在可用于得到TYTFTDYVD的共有基序的高度保守的氨基酸序列。

    Extracellular matrix-binding proteins from staphylococcus aureus
    10.
    发明授权
    Extracellular matrix-binding proteins from staphylococcus aureus 有权
    来自金黄色葡萄球菌的细胞外基质结合蛋白

    公开(公告)号：US06680195B1

    公开(公告)日：2004-01-20

    申请号：US09200650

    申请日：1998-11-25

    申请人： Joseph M. Patti ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A. O. Hook ,  Samuel E. Perkins

    发明人： Joseph M. Patti ,  Timothy J. Foster ,  Elisabet Josefsson ,  Deidre Ni Eidhin ,  Magnus A. O. Hook ,  Samuel E. Perkins

    IPC分类号： C07H2104

    CPC分类号： G01N33/56938 ,  A61K38/00 ,  A61K39/00 ,  C07K14/31 ,  G01N2469/00 ,  Y10S435/975 ,  Y10S530/81 ,  Y10S530/825

    摘要： Isolated extracellular matrix-binding proteins, designated ClfB, SdrC, SdrD and SdrE, and their corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials. ClfB is a cell-wall associated protein having a predicted molecular weight of approximately 88 kDa and an apparent molecular weight of approximately 124 kDa, which binds both soluble and immobilized fibrinogen. ClfB binds both the alpha and beta chains of fibrinogen and acts as a clumping factor. SdrC, SdrD and SdrE are cell-wall associated proteins that exhibit cation-dependent ligand binding to the extracellular matrix. It has been discovered that in the A region of SdrC, SdrD, SdrE, ClfA and ClfB, there is a highly conserved amino acid sequence that can be used to derive a consensus motif of TYTFTDYVD (SEQ ID NO: 16).

    摘要翻译： 描述了分离的细胞外基质结合蛋白，命名为ClfB，SdrC，SdrD和SdrE，以及它们相应的氨基酸和核酸序列和基序。 蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。 此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。 特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。 ClfB是具有约88kDa的预测分子量和约124kDa的表观分子量的细胞壁相关蛋白，其结合可溶性和固定的纤维蛋白原。 ClfB结合纤维蛋白原的α链和β链，并作为聚集因子。 SdrC，SdrD和SdrE是表现出阳离子依赖性配体结合细胞外基质的细胞壁相关蛋白。 已经发现，在SdrC，SdrD，SdrE，ClfA和ClfB的A区域中，存在可用于衍生TYTFTDYVD（SEQ ID NO：16）的共有基序的高度保守的氨基酸序列。