公开(公告)号：US20150011850A1

公开(公告)日：2015-01-08

申请号：US14493283

申请日：2014-09-22

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen ,  Vlad Novotny

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen ,  Vlad Novotny

IPC分类号： A61B5/145 ,  A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/6801 ,  A61B2562/04 ,  A61B2562/046

摘要： A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a detector, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The photon transport system includes a dynamically position light directing unit used to, within a measurement time period for a single analyte concentration determination, change any of: radius, energy, intensity, position, incident angle, solid angle, and/or depth of penetration of a beam of photons entering skin of a subject.

摘要翻译： 描述了一种非侵入性分析仪装置及其使用方法，其包括近红外源，检测器和光子传输系统，其被配置为经由分析仪样品光学界面将光子从源引导到检测器。 光子传输系统包括动态位置光导单元，用于在单个分析物浓度测定的测量时间段内改变以下任何一种：半径，能量，强度，位置，入射角，立体角和/或穿透深度 一束进入受试者皮肤的光子。

公开(公告)号：US20150045636A1

公开(公告)日：2015-02-12

申请号：US13963925

申请日：2013-08-09

申请人： Vlad Novotny ,  Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

发明人： Vlad Novotny ,  Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455

CPC分类号： G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of time resolved sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.

摘要翻译： 使用耦合到监视多个检测区域的至少一个二维检测器阵列的多个时分解样本照明区域来描述非侵入性分析仪装置及其使用方法。 照射时间和/或图案与所选检测区域的控制产生光程长度解析组。 选择性地检测检测器的截面像素和/或区域作为波长的函数的不同光通量。 随后分析路径长度解析的光谱组以确定分析物质。 可选地，在映射和/或收集阶段，入射光可以根据以下任何方式在时间上可控地变化：样本探针位置，入射光立体角，入射光角，焦深，能量，强度和/或检测角 。 任选地，在分析物质性测定中使用与生理特性相关的一种或多种生理特性和/或模型性质。

公开(公告)号：US20150041656A1

公开(公告)日：2015-02-12

申请号：US13963933

申请日：2013-08-09

申请人： Vlad Novotny ,  Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

发明人： Vlad Novotny ,  Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC分类号： G01J3/42 ,  A61B5/145 ,  A61B5/1455

CPC分类号： G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of time resolved sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.

摘要翻译： 使用耦合到监视多个检测区域的至少一个二维检测器阵列的多个时分解样本照明区域来描述非侵入性分析仪装置及其使用方法。 照射时间和/或图案与所选检测区域的控制产生光程长度解析组。 选择性地检测检测器的截面像素和/或区域作为波长的函数的不同光通量。 随后分析路径长度解析的光谱组以确定分析物质。 可选地，在映射和/或收集阶段，入射光可以根据以下任何方式在时间上可控地变化：样本探针位置，入射光立体角，入射光角，焦深，能量，强度和/或检测角 。 任选地，在分析物质性测定中使用与生理特性相关的一种或多种生理特性和/或模型性质。

公开(公告)号：US20150011849A1

公开(公告)日：2015-01-08

申请号：US14493266

申请日：2014-09-22

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/145

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6801 ,  A61B2562/04 ,  A61B2562/046

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of sample illumination zones optically coupled to at least two optically stacked two-dimensional optical filter arrays. Sectioned pixels and/or zones of a detector array are optionally filtered for different light throughput and/or are passed through various pathlengths using the stacked two-dimensional optical filter arrays. Resulting pathlength resolved/wavelength controlled groups of spectra are subsequently analyzed to determine an analyte property.

摘要翻译： 使用光学耦合到至少两个光学堆叠的二维光学滤波器阵列的多个采样照明区域来描述非侵入性分析仪装置及其使用方法。 可选地，为了不同的光通过量滤波检测器阵列的截面像素和/或区域，和/或使用堆叠的二维光学滤波器阵列通过各种路径长度。 随后分析得到的光程长度解析/波长控制的光谱组，以确定分析物质。

公开(公告)号：US20060217602A1

公开(公告)日：2006-09-28

申请号：US11367884

申请日：2006-03-03

申请人： Alan Abul-Haj ,  Thomas Blank ,  Kevin Hazen ,  James Henderson ,  Timothy Ruchti ,  Josh Hope

发明人： Alan Abul-Haj ,  Thomas Blank ,  Kevin Hazen ,  James Henderson ,  Timothy Ruchti ,  Josh Hope

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/1495 ,  A61B5/7264 ,  A61B2562/0242 ,  A61B2562/146

摘要： The invention relates to noninvasive sampling. In one embodiment, the invention relates to a sample probe interface method and apparatus for targeting a tissue depth and/or pathlength that is used in conjunction with a noninvasive analyzer to control spectral variation. In a second embodiment, a signal from a sample or target probe of a tissue feature or volume is used in positioning a portion of a measuring system relative to the sample. The system is optionally used in conjunction with a targeting system used to control the sampling location of the measuring system.

公开(公告)号：US20150011848A1

公开(公告)日：2015-01-08

申请号：US14493234

申请日：2014-09-22

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61M5/172 ,  A61B5/145

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6801 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726

摘要： A noninvasive analyzer apparatus and method of use thereof is described using one or a plurality of sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.

摘要翻译： 使用耦合到监视多个检测区域的至少一个二维检测器阵列的一个或多个样本照明区域来描述非侵入性分析仪装置及其使用方法。 照射时间和/或图案与所选检测区域的控制产生光程长度解析组。 选择性地检测检测器的截面像素和/或区域作为波长的函数的不同光通量。 随后分析路径长度解析的光谱组以确定分析物质。 可选地，在映射和/或收集阶段，入射光可以根据以下任何方式在时间上可控地变化：样本探针位置，入射光立体角，入射光角，焦深，能量，强度和/或检测角 。 任选地，在分析物质性测定中使用与生理特性相关的一种或多种生理特性和/或模型性质。

公开(公告)号：US20060206018A1

公开(公告)日：2006-09-14

申请号：US11368234

申请日：2006-03-03

申请人： Alan Abul-Haj ,  Thomas Blank ,  Kevin Hazen ,  James Henderson ,  Timothy Ruchti ,  Josh Hope

发明人： Alan Abul-Haj ,  Thomas Blank ,  Kevin Hazen ,  James Henderson ,  Timothy Ruchti ,  Josh Hope

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/1495 ,  A61B5/7264 ,  A61B2562/0242 ,  A61B2562/146

摘要： The invention relates to noninvasive sampling. In one embodiment, the invention relates to a sample probe interface method and apparatus for targeting a tissue depth and/or pathlength that is used in conjunction with a noninvasive analyzer to control spectral variation. In a second embodiment, a signal from a sample or target probe of a tissue feature or volume is used in positioning a portion of a measuring system relative to the sample. The system is optionally used in conjunction with a targeting system used to control the sampling location of the measuring system.

摘要翻译： 本发明涉及无创取样。 在一个实施例中，本发明涉及用于靶向与非侵入性分析仪结合使用以控制光谱变化的组织深度和/或光程长度的样本探针接口方法和装置。 在第二实施例中，来自组织特征或体积的样本或目标探针的信号用于相对于样本定位测量系统的一部分。 该系统可选地与用于控制测量系统的采样位置的瞄准系统结合使用。

公开(公告)号：US09375170B2

公开(公告)日：2016-06-28

申请号：US14938688

申请日：2015-11-11

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： G01N5/02 ,  A61B5/1455 ,  A61B5/145 ,  A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6801 ,  A61B2562/04 ,  A61B2562/046

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of sample illumination zones optically coupled to at least two optically stacked two-dimensional optical filter arrays. Sectioned pixels and/or zones of a detector array are optionally filtered for different light throughput and/or are passed through various pathlengths using the stacked two-dimensional optical filter arrays. Resulting pathlength resolved/wavelength controlled groups of spectra are subsequently analyzed to determine an analyte property.

摘要翻译： 使用光学耦合到至少两个光学堆叠的二维光学滤波器阵列的多个采样照明区域来描述非侵入性分析仪装置及其使用方法。 可选地，为了不同的光通过量滤波检测器阵列的截面像素和/或区域，和/或使用堆叠的二维光学滤波器阵列通过各种路径长度。 随后分析得到的光程长度解析/波长控制的光谱组，以确定分析物质。

公开(公告)号：US20160151002A1

公开(公告)日：2016-06-02

申请号：US14943990

申请日：2015-11-17

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/6801 ,  A61B2562/04 ,  A61B2562/046

摘要： A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a detector, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The photon transport system includes a dynamically position light directing unit used to, within a measurement time period for a single analyte concentration determination, change any of: radius, energy, intensity, position, incident angle, solid angle, and/or depth of penetration of a beam of photons entering skin of a subject.

公开(公告)号：US09351671B2

公开(公告)日：2016-05-31

申请号：US14493234

申请日：2014-09-22

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： A61B5/00 ,  A61B5/1455 ,  A61B5/145 ,  A61M5/172

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6801 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726

摘要： A noninvasive analyzer apparatus and method of use thereof is described using one or a plurality of sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.

摘要翻译： 使用耦合到监视多个检测区域的至少一个二维检测器阵列的一个或多个样本照明区域来描述非侵入性分析仪装置及其使用方法。 照射时间和/或图案与所选检测区域的控制产生光程长度解析组。 选择性地检测检测器的截面像素和/或区域作为波长的函数的不同光通量。 随后分析路径长度解析的光谱组以确定分析物质。 可选地，在映射和/或收集阶段，入射光可以根据以下任何方式在时间上可控地变化：样本探针位置，入射光立体角，入射光角，焦深，能量，强度和/或检测角 。 任选地，在分析物质性测定中使用与生理特性相关的一种或多种生理特性和/或模型性质。