公开(公告)号：US12070465B2

公开(公告)日：2024-08-27

申请号：US18031998

申请日：2021-09-15

申请人： Ting Therapeutics LLC

发明人： Jian Zuo ,  Jeff North ,  Santanu Hati ,  Marisa Laura Zallocchi

IPC分类号： A61K31/55 ,  A61K31/397 ,  A61K31/45 ,  A61P27/16

CPC分类号： A61K31/55 ,  A61K31/397 ,  A61K31/45 ,  A61P27/16

摘要： In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-S,6-dihydropyridin-2(1H)-one and derivatives exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice. In one aspect, (E)-1-(3-(3,4,5-trimethoxy phenyl)acryloyl)-S,6-dihydropyridin-2(1H)-one and derivatives can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20230330097A1

公开(公告)日：2023-10-19

申请号：US18031998

申请日：2021-09-16

申请人： Ting Therapeutics LLC

发明人： Jian Zuo ,  Jeff North

IPC分类号： A61K31/55 ,  A61K31/397 ,  A61K31/45 ,  A61P27/16

CPC分类号： A61K31/55 ,  A61K31/397 ,  A61K31/45 ,  A61P27/16

摘要： In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-S,6-dihydropyridin-2(1H)-one and derivatives exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice. In one aspect, (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-S,6-dihydropyridin-2(1H)-one and derivatives can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.