利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.016 秒)

    Methods for the prevention and treatment of hearing loss
    1.
    发明授权
    Methods for the prevention and treatment of hearing loss 有权

    公开(公告)号：US11766440B1

    公开(公告)日：2023-09-26

    申请号：US18117852

    申请日：2023-03-06

    申请人： Ting Therapeutics LLC

    发明人： Jian Zuo ,  Zhuo Li

    IPC分类号： A61K31/5377 ,  A61P27/16 ,  A61K33/243 ,  A61K31/7036

    CPC分类号： A61K31/5377 ,  A61K31/7036 ,  A61K33/243 ,  A61P27/16

    摘要： In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. Momelotinib and Fedratinib exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice when administered prophylactically. In one aspect, Momelotinib or Fedratinib can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    Methods for the prevention and treatment of hearing loss
    4.
    发明授权
    Methods for the prevention and treatment of hearing loss 有权

    公开(公告)号：US11857551B1

    公开(公告)日：2024-01-02

    申请号：US17371847

    申请日：2021-07-09

    申请人： Ting Therapeutics LLC

    发明人： Jian Zuo ,  Pezhman Salehi Dermanaki

    IPC分类号： A61K31/517 ,  A61K45/06 ,  A61K31/513 ,  A61F11/00

    CPC分类号： A61K31/517 ,  A61F11/00 ,  A61K31/513 ,  A61K45/06

    摘要： Acquired hearing loss due to chemotherapy or noise exposure is a major health problem, and cisplatin chemotherapy often causes permanent hearing loss in cancer patients. However, there are no FDA-approved drugs for the treatment or prevention of cisplatin- or noise-induced hearing loss. In one aspect, use of compounds as an active agent to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    Methods for the Prevention and Treatment of Hearing Loss
    8.
    发明公开
    Methods for the Prevention and Treatment of Hearing Loss 审中-公开

    公开(公告)号：US20240350492A1

    公开(公告)日：2024-10-24

    申请号：US18200148

    申请日：2021-07-09

    申请人： Ting Therapeutics LLC

    发明人： Jian Zuo

    IPC分类号： A61K31/517 ,  A61K31/167 ,  A61P27/16

    CPC分类号： A61K31/517 ,  A61K31/167 ,  A61P27/16

    摘要： In one aspect, use of Afatinib as an active agent to treat a hearing loss and to prevent a hearing loss, and methods of treating and/or preventing hearing loss or disorders using the compositions are disclosed. In particular, a method for treating sensorineural hearing loss, including the steps of delivering to a patient in need thereof a composition comprising a therapeutically effective amount of Afatinib. or pharmaceutically acceptable salt thereof is provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    Compositions and Methods for the Prevention and Treatment of Hearing Loss
    9.
    发明公开
    Compositions and Methods for the Prevention and Treatment of Hearing Loss 审中-公开

    公开(公告)号：US20230330097A1

    公开(公告)日：2023-10-19

    申请号：US18031998

    申请日：2021-09-16

    申请人： Ting Therapeutics LLC

    发明人： Jian Zuo ,  Jeff North

    IPC分类号： A61K31/55 ,  A61K31/397 ,  A61K31/45 ,  A61P27/16

    CPC分类号： A61K31/55 ,  A61K31/397 ,  A61K31/45 ,  A61P27/16

    摘要： In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-S,6-dihydropyridin-2(1H)-one and derivatives exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice. In one aspect, (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-S,6-dihydropyridin-2(1H)-one and derivatives can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.