专利检索 ap:("Ting Therapeutics LLC") AND inv:"Santanu Hati" 第 1 页

1.

发明授权
Compositions and methods for the prevention and treatment of hearing loss 有权

公开(公告)号：US12070465B2

公开(公告)日：2024-08-27

申请号：US18031998

申请日：2021-09-15

申请人： Ting Therapeutics LLC

发明人： Jian Zuo , Jeff North , Santanu Hati , Marisa Laura Zallocchi

IPC分类号： A61K31/55 , A61K31/397 , A61K31/45 , A61P27/16

CPC分类号： A61K31/55 , A61K31/397 , A61K31/45 , A61P27/16

摘要： In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-S,6-dihydropyridin-2(1H)-one and derivatives exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice. In one aspect, (E)-1-(3-(3,4,5-trimethoxy phenyl)acryloyl)-S,6-dihydropyridin-2(1H)-one and derivatives can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.