公开(公告)号：US11857551B1

公开(公告)日：2024-01-02

申请号：US17371847

申请日：2021-07-09

申请人： Ting Therapeutics LLC

发明人： Jian Zuo ,  Pezhman Salehi Dermanaki

IPC分类号： A61K31/517 ,  A61K45/06 ,  A61K31/513 ,  A61F11/00

CPC分类号： A61K31/517 ,  A61F11/00 ,  A61K31/513 ,  A61K45/06

摘要： Acquired hearing loss due to chemotherapy or noise exposure is a major health problem, and cisplatin chemotherapy often causes permanent hearing loss in cancer patients. However, there are no FDA-approved drugs for the treatment or prevention of cisplatin- or noise-induced hearing loss. In one aspect, use of compounds as an active agent to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20230285418A1

公开(公告)日：2023-09-14

申请号：US18081951

申请日：2022-12-15

申请人： Ting Therapeutics LLC

发明人： Jian Zuo ,  Pezhman Salehi Dermanaki ,  Marisa Laura Zallocchi ,  Sarath Vijayakumar

IPC分类号： A61K31/609 ,  A61K31/397 ,  A61K31/165 ,  A61K31/122 ,  A61P27/16

CPC分类号： A61K31/609 ,  A61K31/397 ,  A61K31/165 ,  A61K31/122 ,  A61P27/16

摘要： Acquired hearing loss due to chemotherapy or noise exposure is a major health problem, and Cisplatin chemotherapy often causes permanent hearing loss in cancer patients. However, there are no FDA-approved drugs for the treatment or prevention of Cisplatin- or noise-induced hearing loss. In one aspect, use of Niclosamide, Ingenol, and Elesclomol as an active agent to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.