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    Cavernous nerve stimulation via unidirectional propagation of action potentials
    7.
    发明授权
    Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
    通过动作电位的单向传播进行海绵体神经刺激

    公开(公告)号：US07203548B2

    公开(公告)日：2007-04-10

    申请号：US10176743

    申请日：2002-06-20

    申请人： Todd K Whitehurst ,  James P McGivern ,  Rafael Carbunaru ,  Matthew I Haller ,  Tom Xiaohai He ,  Kerry Bradley

    发明人： Todd K Whitehurst ,  James P McGivern ,  Rafael Carbunaru ,  Matthew I Haller ,  Tom Xiaohai He ,  Kerry Bradley

    IPC分类号： A61N1/05 ,  A61N1/18

    CPC分类号： A61N1/0556 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/37205

    摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. In one aspect, a method includes providing at least one implantable stimulator with at least two electrodes, disposing the electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve, thereby treating erectile dysfunction while limiting side effects of bidirectional stimulation.

    摘要翻译： 提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。 能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。 一方面，一种方法包括：提供至少一个可植入的刺激器，其具有至少两个电极，设置所述电极以施加沿着海绵体神经单向传播动作电位的刺激; 并将刺激施加到海绵状神经，从而治疗勃起功能障碍，同时限制双向刺激的副作用。

    Cavernous nerve stimulation via unidirectional propagation of action potentials
    9.
    发明授权
    Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
    通过动作电位的单向传播进行海绵体神经刺激

    公开(公告)号：US07899539B2

    公开(公告)日：2011-03-01

    申请号：US11536565

    申请日：2006-09-28

    申请人： Todd K. Whitehurst ,  James P. McGivern ,  Rafael Carbunaru ,  Matthew I. Haller ,  Tom Xiaohai He ,  Kerry Bradley

    发明人： Todd K. Whitehurst ,  James P. McGivern ,  Rafael Carbunaru ,  Matthew I. Haller ,  Tom Xiaohai He ,  Kerry Bradley

    IPC分类号： A61N1/05 ,  A61N1/372

    CPC分类号： A61N1/0556 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/37205

    摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. A method of stimulating a cavernous nerve includes providing at least one implantable stimulator with at least two cathodic electrodes; programming stimulation parameters for the cathodic electrodes to radially steer an electric field generated by the cathodic electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve in accordance with the stimulation parameters to generate orthodromic action potentials traveling in one direction along the nerve, thereby limiting side effects of bidirectional stimulation.

    摘要翻译： 提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。 能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。 刺激海绵体神经的方法包括：提供至少一个可植入的刺激器，其具有至少两个阴极电极; 用于阴极电极的编程刺激参数以径向转向由阴极电极产生的电场，以施加沿着海绵状神经单向传播动作电位的刺激; 并根据刺激参数对海绵体神经施加刺激，以产生沿着神经沿一个方向行进的正常动作电位，从而限制双向刺激的副作用。