公开(公告)号：US06915157B2

公开(公告)日：2005-07-05

申请号：US10368278

申请日：2003-02-18

申请人： Tommy D. Bennett ,  Lawrence J. Mulligan ,  Edwin G. Duffin ,  Robert C. Hamlen ,  Wael Abo-Auda

发明人： Tommy D. Bennett ,  Lawrence J. Mulligan ,  Edwin G. Duffin ,  Robert C. Hamlen ,  Wael Abo-Auda

IPC分类号： A61B5/00 ,  A61B5/0215 ,  A61B5/0245 ,  A61B5/0452 ,  A61B5/04

CPC分类号： A61B5/02405 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/0245 ,  A61B5/0452

摘要： An implantable heart monitor (IHM) implanted in a patient's body having electrogram (EGM) sense electrodes coupled with EGM sense circuitry to generate sense events upon detection of cardiac depolarizations and a blood pressure measurement transducer disposed in a heart chamber and coupled with blood pressure measurement circuitry operates to assess heart failure state as a function of mechanical pulsus alternans (MPA). MPA episodes are detected, and MPA characteristics of the MPA episode are used alone or as a group as a diagnostic marker of HF state. The MPA episode data set can be stored in memory associated with a time and date stamp. The MPA characteristics of each MPA data set in a series of MPA data sets collected over time can be compared or plotted to determine if a trend indicative of change in HF state is discernible.

摘要翻译： 一种植入式心脏监测器（IHM），其植入患者体内，其具有与EGM感测电路耦合的电描记图（EGM）感测电极，以便在检测到心脏去极化时产生感测事件，以及设置在心室中的血压测量换能器，并与血压测量结合 电路用于评估作为机械脉动交替（MPA）的函数的心力衰竭状态。 检测到MPA发作，MPA发作的MPA特征单独使用或作为HF状态的诊断标记使用。 MPA情节数据集可以存储在与时间和日期戳相关联的存储器中。 可以比较或绘制在一段时间内收集的一系列MPA数据集中的每个MPA数据集的MPA特性，以确定指示HF状态变化的趋势是否可辨别。

公开(公告)号：US08591543B2

公开(公告)日：2013-11-26

申请号：US13096081

申请日：2011-04-28

申请人： Wael Abo-Auda ,  Waleed Abughazaleh

发明人： Wael Abo-Auda ,  Waleed Abughazaleh

IPC分类号： A61B17/08

CPC分类号： A61B17/0057 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00619

摘要： The present invention provides devices and methods for closing a physical anomaly comprising two overlapping layers of tissue, such as a patent foramen ovale (“PFO”). A PFO is comprised of two overlapping layers of malformed interatrial septa, the septum primum and the septum secundum, that form a tunnel between the right atrium and the left atrium. The closure device includes two wings connected to a central arm. The device is delivered through the PFO tunnel in a substantially linear configuration such that the central arm is seated within the PFO tunnel, the first wing extends into the right atrium, and the second wing extends into the left atrium. Once implanted, the closure device is reconfigured such that the arm is seated within the PFO tunnel, the first wing folds against the septum secundum, and the second wing folds against the septum primum, thereby sealing the defect.

摘要翻译： 本发明提供了用于关闭包括两个重叠的组织层的物理异常的装置和方法，例如卵圆孔卵孔（“PFO”）。 PFO由两层重叠的畸形宫内隔膜，隔膜隔膜和隔膜间隔构成，在右心房和左心房之间形成隧道。 闭合装置包括连接到中心臂的两个翼。 该设备通过PFO隧道以基本上线性的构造传送，使得中央臂位于PFO隧道内，第一翼延伸到右心房，第二翼延伸到左心房。 一旦植入，闭合装置被重新配置，使得臂位于PFO隧道内，第一翼折叠在隔膜上，第二翼折叠在隔膜上，从而密封缺陷。

公开(公告)号：US20120277791A1

公开(公告)日：2012-11-01

申请号：US13096081

申请日：2011-04-28

申请人： Wael Abo-Auda ,  Waleed Abughazaleh

发明人： Wael Abo-Auda ,  Waleed Abughazaleh

IPC分类号： A61B17/08

CPC分类号： A61B17/0057 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00619

摘要： The present invention provides devices and methods for closing a physical anomaly comprising two overlapping layers of tissue, such as a patent foramen ovale (“PFO”). A PFO is comprised of two overlapping layers of malformed interatrial septa, the septum primum and the septum secundum, that form a tunnel between the right atrium and the left atrium. The closure device includes two wings connected to a central arm. The device is delivered through the PFO tunnel in a substantially linear configuration such that the central arm is seated within the PFO tunnel, the first wing extends into the right atrium, and the second wing extends into the left atrium. Once implanted, the closure device is reconfigured such that the arm is seated within the PFO tunnel, the first wing folds against the septum secundum, and the second wing folds against the septum primum, thereby sealing the defect.

摘要翻译： 本发明提供了用于关闭物理异常的装置和方法，所述物理异常包括两个重叠的组织层，例如卵圆孔卵孔（PFO）。 PFO由两层重叠的畸形宫内隔膜，隔膜隔膜和隔膜间隔构成，在右心房和左心房之间形成隧道。 闭合装置包括连接到中心臂的两个翼。 该设备通过PFO隧道以基本上线性的构造传送，使得中央臂位于PFO隧道内，第一翼延伸到右心房，第二翼延伸到左心房。 一旦植入，闭合装置被重新配置，使得臂位于PFO隧道内，第一翼折叠在隔膜上，第二翼折叠在隔膜上，从而密封缺陷。