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公开(公告)号:US07652025B2
公开(公告)日:2010-01-26
申请号:US10477062
申请日:2002-05-08
CPC分类号: A61K31/40 , A61K31/485 , A61K38/00 , C07D489/08 , C07K5/1016
摘要: A therapeutic agent for sepsis and various symptoms accompanying sepsis (such as septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome and multiple organ dysfunction) is disclosed. The therapeutic agent for sepsis according to the present invention comprises as an effective ingredient an opioid κ receptor agonist compound such as (−)-17-(cyclopropylmethyl)-3,14β-dihydroxy-4,5α-epoxy-6β[N-methyl-trans-3-(3-furyl)acrylamide] oxide derivative. The opioid κ receptor agonist compound may be administered as it is or in the form of a pharmaceutical composition prepared by mixing the compound with a known pharmaceutically acceptable acid, carrier or vehicle orally or parenterally.
摘要翻译: 公开了脓毒症和伴随脓毒症的各种症状的治疗剂(例如脓毒性休克,弥散性血管内凝血综合征,成人呼吸窘迫综合征和多器官功能障碍)。 根据本发明的败血症治疗剂包括作为有效成分的阿片样物质κ受体激动剂化合物,例如( - ) - 17-(环丙基甲基)-3,14β-二羟基-4,5α-环氧-6β-[N-甲基 (3-呋喃基)丙烯酰胺]氧化物衍生物。 阿片样物质κ受体激动剂化合物可以原样或以通过将化合物与已知的药学上可接受的酸,载体或载体口服或胃肠外混合制备的药物组合物的形式进行给药。
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公开(公告)号:US06583151B2
公开(公告)日:2003-06-24
申请号:US09297364
申请日:1999-07-12
申请人: Hiroshi Nagase , Takashi Endoh , Tsutomu Suzuki , Kuniaki Kawamura , Koji Oshima , Hideaki Inada
发明人: Hiroshi Nagase , Takashi Endoh , Tsutomu Suzuki , Kuniaki Kawamura , Koji Oshima , Hideaki Inada
IPC分类号: A61K314748
CPC分类号: A61K31/485 , C07D489/08
摘要: A method for treating drug dependence comprising administering, as the active ingredient, an opioid &kgr; receptor agonist of a compound represented by the following formula, is disclosed wherein A and the R terms are herein defined.
摘要翻译: 一种治疗药物依赖性的方法,包括给予作为活性成分的由下式表示的化合物的阿片样物质κ受体激动剂,其中A和R术语在本文中定义。
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