摘要:
A therapeutic agent for sepsis and various symptoms accompanying sepsis (such as septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome and multiple organ dysfunction) is disclosed. The therapeutic agent for sepsis according to the present invention comprises as an effective ingredient an opioid κ receptor agonist compound such as (−)-17-(cyclopropylmethyl)-3,14β-dihydroxy-4,5α-epoxy-6β[N-methyl-trans-3-(3-furyl)acrylamide] oxide derivative. The opioid κ receptor agonist compound may be administered as it is or in the form of a pharmaceutical composition prepared by mixing the compound with a known pharmaceutically acceptable acid, carrier or vehicle orally or parenterally.
摘要:
The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.
摘要:
The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.
摘要:
This invention provides an antipruritc comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.
摘要:
This invention provides an antipuritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphian quaternary ammonium salt derivative and a new morphian-N-oxide derivative which are useful in treating puritus complicated with some diseases.
摘要:
This invention provides an antipruritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.
摘要:
A video recorder includes a schedule reconfiguration section having: a local deterioration determining module that determines whether a local deterioration in a recording state occurs by performing simulating the recording state obtained when the reallocated resources are used for performing the programmed recordings and comparing the simulated recording state with a recording state obtained when the resources before the reallocation is used for performing the programmed recordings; and an allocation restoring module that restores the reallocated resources at a part causing the local deterioration to the resources allocated before the reallocation when the local deterioration determining module determines the occurrence of the local deterioration.
摘要:
A cyclopropane derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof has orexin receptor inhibitory action, and thus, is extremely useful as an agent for preventing or treating sleep disorder or dyssomnia caused by orexin, including insomnia as a typical example: wherein A1, A2 and A3 each independently represent an aryl group, a heterocyclyl group or the like, R1, R2 and R3 each independently represent a hydrogen atom, a C1-6 alkyl group or the like, X represents an oxygen atom or the like, and L represents a bond or the like.
摘要:
An illuminating apparatus has a reduced number of mounting spots by soldering or the like to permit an increased yield rate and a reduced cost. The illuminating apparatus has light emitting diodes, lead frames, and a transparent sealer. N light emitting diodes, N sets of lead frames mounted with the N light emitting diodes, and one set or more of lead frames each not mounted with a light emitting diode are sealed by the transparent sealer for integration into a modular illuminating apparatus. Also provided are a method for fabricating the illuminating apparatus, and a display apparatus using the illuminating apparatus.
摘要:
According to an aspect of the embodiment, an area control unit refers to usage information of an area management table based on a determined type of an extracted failure information, determines whether the extracted failure information can be stored in a identified lower storage areas, determines a storage location for the extracted failure information in the identified lower storage areas when the extracted failure information can be stored in the identified lower storage areas, and determines a storage location for the extracted failure information in the upper storage areas other than an upper storage area including the identified lower storage areas based on the area management table when the extracted failure information cannot be stored in the identified lower storage areas.