公开(公告)号：US08486965B2

公开(公告)日：2013-07-16

申请号：US13391217

申请日：2010-08-25

申请人： Tomohiro Ohashi ,  Zenyu Shiokawa ,  Yuta Tanaka ,  Satoshi Sasaki

发明人： Tomohiro Ohashi ,  Zenyu Shiokawa ,  Yuta Tanaka ,  Satoshi Sasaki

IPC分类号： A61K31/44

CPC分类号： C07D471/04 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14 ,  C07D487/04 ,  C07D495/04

摘要： The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof.Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

摘要翻译： 本发明提供具有强Smo抑制活性的稠合杂环衍生物及其应用。 特别地，本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐，以及含有该化合物或其前体药物的药物，其为Smo抑制剂或预防或 治疗癌症。

公开(公告)号：US20120220569A1

公开(公告)日：2012-08-30

申请号：US13391217

申请日：2010-08-25

申请人： Tomohiro Ohashi ,  Zenyu Shiokawa ,  Yuta Tanaka ,  Satoshi Sasaki

发明人： Tomohiro Ohashi ,  Zenyu Shiokawa ,  Yuta Tanaka ,  Satoshi Sasaki

IPC分类号： A61K31/437 ,  C07D495/04 ,  A61P35/00 ,  C07D487/04 ,  A61K31/4985 ,  A61K31/55 ,  C07D471/04 ,  A61K31/4365

CPC分类号： C07D471/04 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14 ,  C07D487/04 ,  C07D495/04

摘要： The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof.Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

摘要翻译： 本发明提供具有强Smo抑制活性的稠合杂环衍生物及其应用。 特别地，本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐，以及含有该化合物或其前体药物的药物，其为Smo抑制剂或预防或 治疗癌症。

公开(公告)号：US08927718B2

公开(公告)日：2015-01-06

申请号：US13391799

申请日：2010-08-25

申请人： Satoshi Sasaki ,  Yuta Tanaka

发明人： Satoshi Sasaki ,  Yuta Tanaka

IPC分类号： C07D471/04 ,  A61K31/437

CPC分类号： C07D471/04

摘要： The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof.Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

摘要翻译： 本发明提供具有强Smo抑制活性的稠合杂环衍生物及其应用。 特别地，本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐，以及含有该化合物或其前体药物的药物，其为Smo抑制剂或预防或 治疗癌症。

公开(公告)号：US08907089B2

公开(公告)日：2014-12-09

申请号：US13391791

申请日：2010-08-25

申请人： Satoshi Sasaki ,  Yuta Tanaka

发明人： Satoshi Sasaki ,  Yuta Tanaka

IPC分类号： C07D471/04 ,  A61K31/437

CPC分类号： C07D471/04

摘要： The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof.Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

摘要翻译： 本发明提供具有强Smo抑制活性的稠合杂环衍生物及其应用。 特别地，本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐，以及含有该化合物或其前体药物的药物，其为Smo抑制剂或预防或 治疗癌症。

公开(公告)号：US20120220570A1

公开(公告)日：2012-08-30

申请号：US13391791

申请日：2010-08-25

申请人： Satoshi Sasaki ,  Yuta Tanaka

发明人： Satoshi Sasaki ,  Yuta Tanaka

IPC分类号： A61K31/4545 ,  C07D471/04 ,  A61K31/444 ,  A61K31/5377 ,  A61K31/437 ,  A61P35/00 ,  A61K31/55

CPC分类号： C07D471/04

摘要： The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof.Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

公开(公告)号：US20120208794A1

公开(公告)日：2012-08-16

申请号：US13391799

申请日：2010-08-25

申请人： Satoshi Sasaki ,  Yuta Tanaka

发明人： Satoshi Sasaki ,  Yuta Tanaka

IPC分类号： A61K31/4545 ,  A61K31/55 ,  A61K31/444 ,  A61P35/00 ,  A61K31/437 ,  C07D471/04 ,  A61K31/5377

CPC分类号： C07D471/04

摘要： The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof.Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

公开(公告)号：US20230284951A1

公开(公告)日：2023-09-14

申请号：US18178759

申请日：2023-03-06

申请人： Koki Ishida ,  Taishi Watanabe ,  Shigenori Kawabata ,  Yuta Tanaka

发明人： Koki Ishida ,  Taishi Watanabe ,  Shigenori Kawabata ,  Yuta Tanaka

IPC分类号： A61B5/243 ,  A61B5/00

CPC分类号： A61B5/243 ,  A61B5/743

摘要： The present invention is designed such that, even when inward currents cannot be calculated properly, it is possible to generate current waveforms that can appropriately evaluate the action of a target body tissue by calculating currents that are equivalent to inward currents. A biomagnetic field measurement system includes circuitry and a memory storing executable instructions which, when executed by the circuitry, cause the circuitry to: based on current components extracted from current signals calculated from a biomagnetic field signal, add up current waveforms of current components along a conduction pathway of an action current in a body tissue that is targeted for evaluation, and generate a current waveform for evaluating an intra-cellular current flowing in the conduction pathway, locations of the current components of the added current waveforms being predetermined set distances apart on the conduction pathway, in front of and behind a location of interest on the conduction pathway.

公开(公告)号：US09506125B2

公开(公告)日：2016-11-29

申请号：US13910313

申请日：2013-06-05

申请人： Shigeki Ueta ,  Hiroyuki Takabayashi ,  Ei Kimura ,  Yuta Tanaka ,  Satoshi Takahashi ,  Isao Nakanowatari ,  Kota Sasaki ,  Koshiro Yamane ,  Satoru Yusa

发明人： Shigeki Ueta ,  Hiroyuki Takabayashi ,  Ei Kimura ,  Yuta Tanaka ,  Satoshi Takahashi ,  Isao Nakanowatari ,  Kota Sasaki ,  Koshiro Yamane ,  Satoru Yusa

IPC分类号： C22C38/52 ,  C21D6/00 ,  C22C38/50 ,  C22C38/44 ,  C22C38/06 ,  C21D6/04 ,  C21D6/02 ,  C21D7/13 ,  C21D1/25

CPC分类号： C21D6/004 ,  C21D1/25 ,  C21D6/007 ,  C21D6/02 ,  C21D6/04 ,  C21D7/13 ,  C22C38/06 ,  C22C38/44 ,  C22C38/50 ,  C22C38/52

摘要： The present invention provides a maraging steel containing: 0.10≦C≦0.30 mass %, 6.0≦Ni≦9.4 mass %, 11.0≦Co≦20.0 mass %, 1.0≦Mo≦6.0 mass %, 2.0≦Cr≦6.0 mass %, 0.5≦Al≦1.3 mass %, and Ti≦0.1 mass %, with the balance being Fe and unavoidable impurities, and satisfying 1.00≦A≦1.08, in which A is 0.95+0.35×[C]−0.0092×[Ni]+0.011×[Co]−0.02×[Cr]−0.001×[Mo], where [C] indicates a content (mass %) of C, [Ni] indicates a content (mass %) of Ni, [Co] indicates a content (mass %) of Co, [Cr] indicates a content (mass %) of Cr, and [Mo] indicates a content (mass %) of Mo, respectively. The maraging steel has a tensile strength of 2,300 MPa or more and is also excellent in the toughness/ductility and fatigue characteristics.

摘要翻译： 本发明提供一种马氏体时效钢，其含有：0.10≤C≤0.30质量％，6.0≤Ni≤9.4质量％，11.0≤Co≤20.0质量％，1.0≤Mo≤6.0质量％，2.0≤Cr≤6.0质量％，0.5 ≤Al≤1.3质量％，Ti≤0.1质量％，余量为Fe和不可避免的杂质，满足1.00≤A≤1.08，其中A为0.95 + 0.35×[C] -0.0092×[Ni] +0.011 ×[Co] -0.02×[Cr] -0.001×[Mo]，[C]表示C的含量（质量％），[Ni]表示Ni的含量（质量％），[Co] （质量％），[Cr]表示Cr的含量（质量％），[Mo]分别表示Mo的含量（质量％）。 马氏体时效钢的拉伸强度为2300MPa以上，韧性/延展性，疲劳特性也优异。