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公开(公告)号：US07745499B2
公开(公告)日：2010-06-29
申请号：US10564837
申请日：2004-07-16
IPC分类号： C09K3/00
CPC分类号： B01D65/102 , A61K33/24 , A61K45/06 , B01J13/0043 , Y02A50/465
摘要： A colloid solution that exhibits storage stability and pH stability, being useful as viral substitute particles for use in an integrity test for virus removal membrane. In particular, a metal colloid solution characterized in that it comprises metal particles or metal compound particles of 1 to 100 nm average diameter, a water soluble high-molecular-weight dispersant having an N group and water and/or a water soluble organic solvent, the metal colloid solution being stable for a prolonged period of time and being stable in at least pH values ranging from 4 to 11.
摘要翻译： 具有保存稳定性和pH稳定性的胶体溶液，可用作用于病毒去除膜完整性测试的病毒代用颗粒。 特别是金属胶体溶液，其特征在于它包括平均直径为1至100nm的金属颗粒或金属化合物颗粒，具有N基团的水溶性高分子量分散剂和/或水溶性有机溶剂， 金属胶体溶液长时间稳定，至少在4至11的pH范围内是稳定的。
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公开(公告)号：US20060235085A1
公开(公告)日：2006-10-19
申请号：US10564837
申请日：2004-07-16
CPC分类号： B01D65/102 , A61K33/24 , A61K45/06 , B01J13/0043 , Y02A50/465
摘要： A colloid solution that exhibits storage stability and pH stability, being useful as viral substitute particles for use in an integrity test for virus removal membrane. In particular, a metal colloid solution characterized in that it comprises metal particles or metal compound particles of 1 to 100 nm average diameter, a water soluble high-molecular-weight dispersant having an N group and water and/or a water soluble organic solvent, the metal colloid solution being stable for a prolonged period of time and being stable in at least pH values ranging from 4 to 11.
摘要翻译： 具有保存稳定性和pH稳定性的胶体溶液，可用作用于病毒去除膜完整性测试的病毒代用颗粒。 特别是金属胶体溶液，其特征在于它包括平均直径为1至100nm的金属颗粒或金属化合物颗粒，具有N基团的水溶性高分子量分散剂和/或水溶性有机溶剂， 金属胶体溶液长时间稳定，至少在4至11的pH范围内是稳定的。
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公开(公告)号：US09005445B2
公开(公告)日：2015-04-14
申请号：US12530065
申请日：2008-03-07
申请人： Naoko Hamasaki , Shoichi Ide
发明人： Naoko Hamasaki , Shoichi Ide
CPC分类号： B22F9/24 , B01D65/10 , B01D65/102 , B01D69/08 , B01J13/0043 , B22F2998/00 , G01N2015/084 , B22F1/0022
摘要： The present invention provides a method of testing the integrity of a microporous membrane using a colloid solution containing metal particles or metal compound particles that can accurately determine the integrity of a virus removal membrane formed of hydrophilized synthetic polymer that has been subjected to protein solution filtration, and to provide a method of producing the colloid solution. The colloid solution comprises a solvent and metal particles dispersed in the solvent, and the solvent comprises components (A) and (B), (A) and (C), or (A), (B), and (C), wherein the component (A) is an anionic polymer having a sulfonic acid group, the component (B) is at least one nonionic surfactant selected from the group consisting of a nonionic surfactant having a polycyclic structure in a hydrophobic moiety and a polyoxyethylene sorbitan fatty acid ester, and the component (C) is a water-soluble polymer having a pyrrolidone group.
摘要翻译： 本发明提供一种使用含有金属粒子或金属化合物粒子的胶体溶液测定微多孔膜的完整性的方法，所述金属粒子或金属化合物粒子能够准确地确定由经过蛋白质溶液过滤的亲水化合成聚合物形成的病毒去除膜的完整性， 并提供一种生产胶体溶液的方法。 胶体溶液包含分散在溶剂中的溶剂和金属颗粒，溶剂包含组分（A）和（B），（A）和（C）或（A），（B）和（C） 组分（A）是具有磺酸基的阴离子聚合物，组分（B）是选自疏水部分中具有多环结构的非离子表面活性剂和聚氧乙烯脱水山梨糖醇脂肪酸酯中的至少一种非离子表面活性剂 ，（C）成分为具有吡咯烷酮基的水溶性聚合物。
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公开(公告)号：US20100096328A1
公开(公告)日：2010-04-22
申请号：US12530065
申请日：2008-03-07
申请人： Naoko Hamasaki , Shoichi Ide
发明人： Naoko Hamasaki , Shoichi Ide
CPC分类号： B22F9/24 , B01D65/10 , B01D65/102 , B01D69/08 , B01J13/0043 , B22F2998/00 , G01N2015/084 , B22F1/0022
摘要： [Problem] An object of the present invention is to provide a method of testing the integrity of a microporous membrane using a colloid solution containing metal particles or metal compound particles that can accurately determine the integrity of a virus removal membrane formed of hydrophilized synthetic polymer that has been subjected to protein solution filtration, and to provide a method of producing the colloid solution.[Means for Solving Problem] A method of testing the integrity of a microporous membrane comprising filtering a colloid solution through a microporous membrane, the colloid solution comprising a solvent and metal particles dispersed in the solvent, and the solvent comprising components (A) and (B), (A) and (C), or (A), (B), and (C), wherein the component (A) is an anionic polymer having a sulfonic acid group, the component (B) is at least one nonionic surfactant selected from the group consisting of a nonionic surfactant having a polycyclic structure in a hydrophobic moiety and a polyoxyethylene sorbitan fatty acid ester, and the component (C) is a water-soluble polymer having a pyrrolidone group.
摘要翻译： 本发明的目的在于提供一种使用含有金属粒子或金属化合物粒子的胶体溶液测定微多孔膜的完整性的方法，所述金属粒子或金属化合物粒子可以精确地确定由亲水化的合成聚合物形成的病毒去除膜的完整性， 已经进行蛋白质溶液过滤，并提供了生产胶体溶液的方法。 [解决问题的方法]一种测试微孔膜的完整性的方法，包括通过微孔膜过滤胶体溶液，胶体溶液包含分散在溶剂中的溶剂和金属颗粒，以及包含组分（A）和（ B），（A）和（C）或（A），（B）和（C），其中组分（A）是具有磺酸基的阴离子聚合物，组分（B） 选自疏水部分中具有多环结构的非离子表面活性剂和聚氧乙烯山梨糖醇酐脂肪酸酯的非离子表面活性剂，（C）成分为具有吡咯烷酮基的水溶性聚合物。
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公开(公告)号：US06797169B1
公开(公告)日：2004-09-28
申请号：US10048550
申请日：2002-05-01
申请人： Shoichi Ide , Toshiaki Noda
发明人： Shoichi Ide , Toshiaki Noda
IPC分类号： B01D7106
CPC分类号： B01D67/0018 , A61L2/0017 , A61L2/022 , B01D61/14 , B01D61/145 , B01D61/147 , B01D69/02 , B01D69/08 , B01D71/10 , B01D2323/22 , B01D2325/04 , B01D2325/20
摘要： Filter membranes for efficiently eliminating pathogens such as viruses from solutions of drugs or physiologically active substances employed as starting materials thereof which are contaminated with pathogens such as viruses. These filter membranes, which can simultaneously achieve favorable performance of eliminating small viruses and a high physiologically active substance-permeability, can be obtained by controlling the membrane characteristics to give a ratio (BP/&ggr;) of the bubble point BP (MPa) to the surface tension &ggr; (N/m) of 110 or above, and/or logarithmic elimination ratios of swine parvovirus at 0 to 5 l/m2 filtration volume and at 50 to 55 l/m2, and regulating the permeability for bovine immunoglubulin, wherein the monomer content amounts to at least 80%, to 70% or more. These filter membranes make it possible to provide drugs or starting materials therefor with little fear of the contamination with viruses, etc. and, therefore, are useful in the fields of pharmacy, medicine and the like.
摘要翻译： 过滤膜用于有效地消除病原体，例如病毒来自药物或作为其原料的生理活性物质的溶液，其被诸如病毒的病原体污染。 通过控制膜特性，可以获得能够同时实现消除小病毒和高生理活性物质渗透性的有利性能的这些过滤膜，从而得到气泡点BP（MPa）的比（BP /γ）与 110或以上的表面张力γ（N / m），和/或猪细小病毒在0至5升/平方米过滤体积和50至55升/平方米的对数消除比，并调节渗透性 对于牛免疫球蛋白，其中单体含量为至少80％至70％以上。 这些过滤膜可以提供药物或起始材料，而不用担心病毒等的污染，因此可用于制药，医药等领域。
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公开(公告)号：US06233903B1
公开(公告)日：2001-05-22
申请号：US09296498
申请日：1999-04-22
申请人： Shoichi Ide
发明人： Shoichi Ide
IPC分类号： B65B920
CPC分类号： B65B61/08 , B65B9/213 , B65B41/16 , B65B51/303 , B65B65/006 , B65B2220/06
摘要： In a multiple automatic packing machine comprising a slitter for slitting a wide sheet-like packing material supplied from a take-up roll into a plurality of packing films, a heat sealing device for seal molding each of the packing films into an elongated bag-like configuration by a vertical heat sealer and a lateral heat sealer, and a material filling device for filling a material to be packed into each of the packing films which has been seal molded into an elongated bag-like configuration through a feed pipe with a filling screw disposed therein which screw is rotatable by a motor, the slitting, heat sealing and material filling operations being repeatedly performed in a consecutive manner by the slitter, heat sealing device and material filling device, respectively, thereby a plurality of stick-like packing products are seal molded at a time automatically and in a consecutive manner, a packing film feeder for the multiple automatic packing machine being characterized in that the feed pipes constituting the material filling device is preliminarily spacedly arranged in side by side relationship so that the motors for rotating the screws will not interfere with each other, a packing material feed portion comprising the take-up roll and the slitter is disposed at a different angle in a lateral direction with respect to an automatic packing portion comprising the material filling device and the heat sealing device, and each of the packing films which has been slit by the slitter and conveyed is trained over a plurality of direction-changing rollers arranged in side by side relationship in a slightly shifted manner in a conveying direction, thereby each of the packing films is changed in direction towards and fed to the automatic packing portion.
摘要翻译： 在一种多重自动包装机中，包括用于将从卷取辊供给的宽的片状包装材料切割成多个包装膜的分切机，用于将每个包装膜密封成细长袋状的热封装置 通过垂直热封机和横向热封机构成的材料填充装置，以及用于将填充材料填充到已经通过具有填充螺杆的进料管密封成细长袋状构造的每个填料膜中的材料填充装置 通过电动机可旋转的螺杆，由分切机，热封装置和材料填充装置分别重复地连续地进行分切，热封和材料填充操作，从而多个棒状包装产品 一次自动密封和连续成型，用于多重自动包装机的包装膜进料器的特征在于， 构成材料填充装置的管道预先间隔布置成并排关系，使得用于旋转螺钉的电动机不会彼此干涉，包括卷取辊和分切机的包装材料供给部分设置在不同的位置 相对于包括材料填充装置和热封装置的自动包装部分在横向方向上的角度，并且通过分切机输送的每个包装膜被训练在多个方向改变辊上， 在输送方向上以稍微偏移的方式并排关系，从而每个包装膜在朝向和供给到自动包装部分的方向上改变。
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