公开(公告)号：US20080248011A1

公开(公告)日：2008-10-09

申请号：US10587841

申请日：2005-01-25

申请人： Tomoko Nakagawa ,  Shunsuke Kurei ,  Shingo Toji ,  Ayako Okabe ,  Motoki Kuhara ,  Yoshiro Kishi ,  Ichiro Yahara

发明人： Tomoko Nakagawa ,  Shunsuke Kurei ,  Shingo Toji ,  Ayako Okabe ,  Motoki Kuhara ,  Yoshiro Kishi ,  Ichiro Yahara

IPC分类号： A61K35/12 ,  C07K16/18 ,  G01N33/569 ,  A61P43/00 ,  A01N1/02 ,  C12N5/06

CPC分类号： C07K16/2803 ,  A61K2035/124 ,  C12N5/0645 ,  G01N33/56972

摘要： The present invention provides HIDE1 as novel monocyte markers. Since HIDE1 are membrane proteins, monocytes can be specifically detected by using antibodies that bind to HIDE1. Further, HIDE1-positive monocytes can also be collected from peripheral blood or the like using a cell sorter, magnet, or such. Monocytes that can be prepared based on the present invention are useful in cell immunotherapy.

摘要翻译： 本发明提供HIDE1作为新颖的单核细胞标志物。 由于HIDE1是膜蛋白，可以通过使用与HIDE1结合的抗体来特异性检测单核细胞。 此外，还可以使用细胞分选器，磁体等从外周血液等收集HIDE1阳性单核细胞。 可以根据本发明制备的单核细胞可用于细胞免疫治疗。

公开(公告)号：US08580925B2

公开(公告)日：2013-11-12

申请号：US11795328

申请日：2005-12-15

申请人： Reiji Kannagi ,  Mineko Izawa ,  Naoko Kimura ,  Shunsuke Kurei ,  Kazue Watanabe

发明人： Reiji Kannagi ,  Mineko Izawa ,  Naoko Kimura ,  Shunsuke Kurei ,  Kazue Watanabe

IPC分类号： C07K16/00

CPC分类号： C07K16/40 ,  C07K16/3076 ,  G01N33/57407 ,  G01N2333/91194 ,  G01N2400/02

摘要： [PROBLEMS] To provide examination methods and reagents able to detect efficiently cancer patients and patients at high risk of cancer.[MEANS FOR SOLVING PROBLEMS] Significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, between non-carcinoma tissues and carcinoma tissues or adenoma tissues were discovered. The discovery is evidently applicable to detect carcinomas and adenomas (except colorectal carcinomas and colorectal adenomas) specifically by assaying a certain range of GlcNAc-6-sulfated sugar residue groups in tissues of patients and in fecal samples. Examination of carcinomas and adenomas is possible by the use of antibodies reacting specifically with GlcNAc-6-sulfated sugar residues specifically synthesized by enzymes present in carcinoma and adenoma tissues.

摘要翻译： [问题]提供能够有效检测癌症患者和癌症高危患者的检查方法和试剂。 [解决问题的方法]发现了GlcNAc-6-磺基转移酶同工酶，糖残基硫酸化酶，非癌组织和癌组织或腺瘤组织分布的显着差异。 该发现显然适用于通过测定患者组织和粪便样品中的一定范围的GlcNAc-6-硫酸化糖残基来检测癌和腺瘤（结肠直肠癌和结肠直肠腺癌除外）。 可以通过使用特异性地与存在于癌和腺瘤组织中的酶特异性合成的GlcNAc-6硫酸化糖残基的抗体来检查癌和腺瘤。

公开(公告)号：US20080096234A1

公开(公告)日：2008-04-24

申请号：US11795328

申请日：2005-12-15

申请人： Reiji Kannagi ,  Mineko Izawa ,  Naoko Kimura ,  Shunsuke Kurei ,  Kazue Watanabe

发明人： Reiji Kannagi ,  Mineko Izawa ,  Naoko Kimura ,  Shunsuke Kurei ,  Kazue Watanabe

IPC分类号： G01N33/574

CPC分类号： C07K16/40 ,  C07K16/3076 ,  G01N33/57407 ,  G01N2333/91194 ,  G01N2400/02

摘要： [PROBLEMS] To provide examination methods and reagents able to detect efficiently cancer patients and patients at high risk of cancer. [MEANS FOR SOLVING PROBLEMS] Significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, between non-carcinoma tissues and carcinoma tissues or adenoma tissues were discovered. The discovery is evidently applicable to detect carcinomas and adenomas (except colorectal carcinomas and colorectal adenomas) specifically by assaying a certain range of GlcNAc-6-sulfated sugar residue groups in tissues of patients and in fecal samples. Examination of carcinomas and adenomas is possible by the use of antibodies reacting specifically with GlcNAc-6-sulfated sugar residues specifically synthesized by enzymes present in carcinoma and adenoma tissues.

摘要翻译： [问题]提供能够有效检测癌症患者和癌症高危患者的检查方法和试剂。 [解决问题的方法]发现了GlcNAc-6-磺基转移酶同工酶，糖残基硫酸化酶，非癌组织和癌组织或腺瘤组织分布的显着差异。 该发现显然适用于通过测定患者组织和粪便样品中的一定范围的GlcNAc-6-硫酸化糖残基来检测癌和腺瘤（结肠直肠癌和结肠直肠腺癌除外）。 可以通过使用特异性地与存在于癌和腺瘤组织中的酶特异性合成的GlcNAc-6硫酸化糖残基的抗体来检查癌和腺瘤。