公开(公告)号：US20130210742A1

公开(公告)日：2013-08-15

申请号：US13703596

申请日：2011-06-23

申请人： Tomomichi Futo ,  Hikaru Taira ,  Seitaro Mizukami ,  Naoyuki Murata

发明人： Tomomichi Futo ,  Hikaru Taira ,  Seitaro Mizukami ,  Naoyuki Murata

IPC分类号： A61K47/34

CPC分类号： A61K47/34 ,  A61K9/19 ,  A61K9/5031 ,  A61K9/5089 ,  A61K38/08 ,  C08J3/005 ,  C08J2367/04 ,  C08J2389/00 ,  C08L67/04 ,  C08L89/00 ,  C08L2666/26

摘要： The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic polymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably releases compound (I) or a salt thereof over a long period of time and exerts medicinal effects of compound (I) or a salt thereof over a long period of time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing frequency of administration, is an excellent formulation as a clinical medicine.

摘要翻译： 本发明涉及包含重金属离子衍生物和重均分子量为约5,000至约40,000的乳酸聚合物或其盐的缓释制剂。 本发明的缓释制剂缓慢且稳定地释放长时间的化合物（I）或其盐，并且长时间地施加化合物（I）或其盐的药用作用。 此外，通过减少给药频率来提高患者便利性的本发明的缓释制剂是作为临床医学的优良配方。

公开(公告)号：US20120302508A1

公开(公告)日：2012-11-29

申请号：US13517202

申请日：2010-12-21

申请人： Tomomichi Futo ,  Hikaru Taira ,  Seitaro Mizukami ,  Naoyuki Murata

发明人： Tomomichi Futo ,  Hikaru Taira ,  Seitaro Mizukami ,  Naoyuki Murata

IPC分类号： A61K38/08 ,  A61P35/00

CPC分类号： A61K9/1647 ,  A61K9/0024

摘要： The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic acid-glycolic acid copolymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably release compound (I) or a salt thereof for a long time and exerts a medicinal effect of compound (I) or a salt thereof for a long time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing the number of administration times, is an excellent formulation as a clinical medicine.

摘要翻译： 本发明涉及一种缓释制剂，其含有重均分子量为约5,000至约40,000的亚氨酸衍生物和乳酸 - 乙醇酸共聚物或其盐。 本发明的缓释制剂长时间缓慢稳定地释放化合物（I）或其盐，长时间发挥化合物（I）或其盐的药用作用。 此外，通过减少给药次数来提高患者便利性的本发明的缓释制剂是作为临床医学的优良配方。