公开(公告)号：US20130210742A1

公开(公告)日：2013-08-15

申请号：US13703596

申请日：2011-06-23

申请人： Tomomichi Futo ,  Hikaru Taira ,  Seitaro Mizukami ,  Naoyuki Murata

发明人： Tomomichi Futo ,  Hikaru Taira ,  Seitaro Mizukami ,  Naoyuki Murata

IPC分类号： A61K47/34

CPC分类号： A61K47/34 ,  A61K9/19 ,  A61K9/5031 ,  A61K9/5089 ,  A61K38/08 ,  C08J3/005 ,  C08J2367/04 ,  C08J2389/00 ,  C08L67/04 ,  C08L89/00 ,  C08L2666/26

摘要： The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic polymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably releases compound (I) or a salt thereof over a long period of time and exerts medicinal effects of compound (I) or a salt thereof over a long period of time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing frequency of administration, is an excellent formulation as a clinical medicine.

摘要翻译： 本发明涉及包含重金属离子衍生物和重均分子量为约5,000至约40,000的乳酸聚合物或其盐的缓释制剂。 本发明的缓释制剂缓慢且稳定地释放长时间的化合物（I）或其盐，并且长时间地施加化合物（I）或其盐的药用作用。 此外，通过减少给药频率来提高患者便利性的本发明的缓释制剂是作为临床医学的优良配方。

公开(公告)号：US20120302508A1

公开(公告)日：2012-11-29

申请号：US13517202

申请日：2010-12-21

申请人： Tomomichi Futo ,  Hikaru Taira ,  Seitaro Mizukami ,  Naoyuki Murata

发明人： Tomomichi Futo ,  Hikaru Taira ,  Seitaro Mizukami ,  Naoyuki Murata

IPC分类号： A61K38/08 ,  A61P35/00

CPC分类号： A61K9/1647 ,  A61K9/0024

摘要： The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic acid-glycolic acid copolymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably release compound (I) or a salt thereof for a long time and exerts a medicinal effect of compound (I) or a salt thereof for a long time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing the number of administration times, is an excellent formulation as a clinical medicine.

摘要翻译： 本发明涉及一种缓释制剂，其含有重均分子量为约5,000至约40,000的亚氨酸衍生物和乳酸 - 乙醇酸共聚物或其盐。 本发明的缓释制剂长时间缓慢稳定地释放化合物（I）或其盐，长时间发挥化合物（I）或其盐的药用作用。 此外，通过减少给药次数来提高患者便利性的本发明的缓释制剂是作为临床医学的优良配方。

公开(公告)号：US20100310670A1

公开(公告)日：2010-12-09

申请号：US12065255

申请日：2006-03-03

申请人： Hiroaki Okada ,  Yuki Takashima ,  Naoyuki Murata

发明人： Hiroaki Okada ,  Yuki Takashima ,  Naoyuki Murata

IPC分类号： A61K31/7105 ,  C07H21/04 ,  C07H21/02 ,  A61K31/711 ,  A61P29/00 ,  A61P31/12 ,  A61K9/14

CPC分类号： A61K9/0048 ,  A61K9/0019 ,  A61K9/1647 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K47/6455 ,  A61K48/00

摘要： A sustained-release microsphere formulation containing a short chain deoxyribonucleic acid or a short chain ribonucleic acid as an active ingredient, which has improved sustained-release properties and long-lasting efficacy, is provided. A fine particle formulation, encapsulating stably a short chain deoxyribonucleic acid or a short chain ribonucleic acid, being capable of inhibiting, for a long period, expression of a specific protein related to a disease, and which can be administered by injection or transmucosally, and a production method of the same are provided. A sustained-release microsphere formulation containing a short chain deoxyribonucleic acid or a short chain ribonucleic acid, particularly siRNA, as an active ingredient, especially a sustained-release microsphere prepared through a w1/o/w2 type emulsion, is characterized in that a positively charged basic substance, such as arginine, polyethylenimine, a cell permeable peptide, poly-L-lysine or poly-L-ornithine, is included in an in vivo degradable polymer.

摘要翻译： 提供了含有短链脱氧核糖核酸或短链核糖核酸作为活性成分的持续释放微球制剂，其具有改善的持续释放性能和持久功效。 能够稳定地包封短链脱氧核糖核酸或短链核糖核酸的微粒制剂能够长时间地抑制与疾病相关的特异性蛋白质的表达，并且可以通过注射或经粘膜施用，以及 提供了其制造方法。 含有短链脱氧核糖核酸或短链核糖核酸，特别是siRNA作为活性成分，特别是通过w1 / o / w2型乳剂制备的持续释放微球的缓释微球制剂的特征在于： 带电的碱性物质，例如精氨酸，聚乙烯亚胺，细胞可渗透肽，聚-L-赖氨酸或聚-L-鸟氨酸，被包括在体内可降解的聚合物中。

公开(公告)号：US5539004A

公开(公告)日：1996-07-23

申请号：US330524

申请日：1994-10-28

申请人： Sadao Ikeda ,  Makoto Kito ,  Yoshio Taguchi ,  Atsushi Tanaka ,  Shigeki Inoue ,  Naoyuki Murata ,  Shinichi Ninomiya ,  Yoshitaka Kimura

发明人： Sadao Ikeda ,  Makoto Kito ,  Yoshio Taguchi ,  Atsushi Tanaka ,  Shigeki Inoue ,  Naoyuki Murata ,  Shinichi Ninomiya ,  Yoshitaka Kimura

IPC分类号： B29B17/00 ,  B29B17/04 ,  B29C47/40 ,  B29C47/60 ,  B29C47/64 ,  B29C47/76 ,  B29K105/26 ,  C08J11/10 ,  C08J11/12 ,  C08J11/04

CPC分类号： B29C47/0825 ,  B29B17/00 ,  B29C47/0021 ,  B29C47/38 ,  B29C47/402 ,  B29C47/60 ,  B29C47/6075 ,  B29C47/64 ,  B29C47/767 ,  C08J11/10 ,  B29K2105/26 ,  Y02P20/582 ,  Y02W30/62 ,  Y02W30/702 ,  Y10S264/911

摘要： A process and an apparatus for recycling resin scrap including a thermosetting resin paint film and a thermoplastic resin substrate as its major components, wherein the resin scrap is supplied into a passage of a cylinder, melted, and delivered by delivering means from an upstream side to a downstream side of the passage of the cylinder, and hydrolyzed by a hydrolyzing agent while forming a highly packed region with a resistor. The resistor restricts the resin scrap to flow from the upstream side to the downstream side in a short period of time, and forms the highly packed region where a contact efficiency is enhanced between the resin scrap and the hydrolyzing agent.

摘要翻译： 一种用于回收包括热固性树脂漆膜和热塑性树脂基材作为主要成分的树脂废料的方法和设备，其中树脂废料被供应到圆筒的通道中，熔化并由输送装置从上游侧输送到 在圆筒的通道的下游侧，并通过水解剂水解，同时形成具有电阻器的高度堆积区域。 电阻器限制树脂废料在短时间内从上游侧流向下游侧，形成树脂废料与水解剂之间接触效率提高的高度堆积区域。

公开(公告)号：US09358740B2

公开(公告)日：2016-06-07

申请号：US14004224

申请日：2012-03-09

申请人： Takatoshi Watanabe ,  Satoru Araya ,  Masahiro Niihori ,  Wataru Iwase ,  Naoya Tabuchi ,  Kazuhiro Ohtaki ,  Yuji Hisatomi ,  Naoto Saito ,  Naoyuki Murata ,  Ryuichi Kawachi ,  Yuji Ito

发明人： Takatoshi Watanabe ,  Satoru Araya ,  Masahiro Niihori ,  Wataru Iwase ,  Naoya Tabuchi ,  Kazuhiro Ohtaki ,  Yuji Hisatomi ,  Naoto Saito ,  Naoyuki Murata ,  Ryuichi Kawachi ,  Yuji Ito

IPC分类号： B29C49/28 ,  B29D22/00 ,  B29C65/00 ,  B29C47/00 ,  B29C69/00 ,  B29C51/12 ,  B29C51/26 ,  B29L31/00 ,  B29C51/02 ,  B29C51/10

CPC分类号： B29D22/003 ,  B29C47/0021 ,  B29C47/0054 ,  B29C47/0066 ,  B29C49/0047 ,  B29C49/04 ,  B29C49/28 ,  B29C51/02 ,  B29C51/105 ,  B29C51/12 ,  B29C51/261 ,  B29C51/267 ,  B29C66/1312 ,  B29C66/532 ,  B29C66/54 ,  B29C66/61 ,  B29C66/71 ,  B29C66/7234 ,  B29C66/73921 ,  B29C66/81463 ,  B29C66/8242 ,  B29C66/8322 ,  B29C66/83221 ,  B29C69/004 ,  B29C2049/0057 ,  B29K2623/065 ,  B29L2031/7172 ,  B29K2023/065

摘要： A production apparatus includes the following stations juxtaposed in the following sequence: a parison forming station for forming a parison; a built-in part attachment station where opposite sides of a center die provided with a built-in part are held between a pair of molding dies to locate the center die in the molding dies with the parison between the center die and the molding dies, and the built-in part being attached to the parison transferred to the molding dies; a molding station where the molding dies are closed to mold the hollow molded product; and a conveyance station for taking the hollow molded product out of the molding dies and conveying the hollow molded product. The center die is fixed at the built-in part attachment station, and the molding dies are configured to be movable back and forth between the built-in part attachment station and the molding station.

摘要翻译： 制造装置包括以下顺序并列的以下工位：用于形成型坯的型坯成型台; 设置有内置部件的中央模具的相对侧的内置部件附接工位被保持在一对成型模具之间，以使中心模具与中心模具和成型模具之间的型坯定位在成型模具中， 并且内置部件附接到转移到模具的型坯上; 成型台，其中模具封闭以模制中空模制产品; 以及用于将中空成型品从模具中取出并输送中空成型品的输送台。 中心模具固定在内置零件安装台上，并且成型模具构造成可在内置零件安装台和模制工位之间来回移动。

公开(公告)号：US20140065255A1

公开(公告)日：2014-03-06

申请号：US13824266

申请日：2012-03-28

申请人： Satoru Araya ,  Shinsuke Yamashita ,  Hiroaki Hayashi ,  Yuji Hisatomi ,  Naoto Saito ,  Naoyuki Murata ,  Ryuichi Kawachi ,  Yuji Ito

发明人： Satoru Araya ,  Shinsuke Yamashita ,  Hiroaki Hayashi ,  Yuji Hisatomi ,  Naoto Saito ,  Naoyuki Murata ,  Ryuichi Kawachi ,  Yuji Ito

IPC分类号： B29C49/42

CPC分类号： B29C49/4242 ,  B29C48/0017 ,  B29C48/0022 ,  B29C48/07 ,  B29C48/09 ,  B29C49/02 ,  B29C49/04 ,  B29C49/4247 ,  B29C49/4252 ,  B29C2049/048 ,  B29C2793/0063 ,  B29C2793/0081

摘要： A guide device 3 for smoothing into a shape of a flat plate a parison P having a semi-circular shape in a planar cross-section, the parison being extruded from an extrusion device 1 and divided into two by a cutter 2, wherein the guide device includes a spiral guide element 4 that is in contact with the parison P while rotating about an axis, the spiral guide element being formed so as to rotate in opposite directions with each other on the left and right of a middle part 4C as a boundary so as to expand the parison P to the left and right. The spiral guide element 4 is formed in a protruding shape on an outer periphery of a shaft 5 rotated by the driving of a drive motor M.

摘要翻译： 导向装置3，用于平坦化平板状的具有半圆形状的型坯P的平板形状，该型坯从挤出装置1挤出并由切割器2分成两部分，其中导向件 装置包括在围绕轴线旋转的同时与型坯P接触的螺旋引导元件4，螺旋引导元件形成为在中间部分4C的左右两侧彼此相反的方向作为边界 以便将型坯P向左和向右扩展。 螺旋引导元件4通过驱动马达M的驱动而旋转的轴5的外周形成为突出形状。

公开(公告)号：US20130341825A1

公开(公告)日：2013-12-26

申请号：US14004224

申请日：2012-03-09

申请人： Takatoshi Watanabe ,  Satoru Araya ,  Masahiro Niihori ,  Wataru Iwase ,  Naoya Tabuchi ,  Kazuhiro Ohtaki ,  Yuji Hisatomi ,  Naoto Saito ,  Naoyuki Murata ,  Ryuichi Kawachi ,  Yuji Ito

发明人： Takatoshi Watanabe ,  Satoru Araya ,  Masahiro Niihori ,  Wataru Iwase ,  Naoya Tabuchi ,  Kazuhiro Ohtaki ,  Yuji Hisatomi ,  Naoto Saito ,  Naoyuki Murata ,  Ryuichi Kawachi ,  Yuji Ito

IPC分类号： B29D22/00

CPC分类号： B29D22/003 ,  B29C47/0021 ,  B29C47/0054 ,  B29C47/0066 ,  B29C49/0047 ,  B29C49/04 ,  B29C49/28 ,  B29C51/02 ,  B29C51/105 ,  B29C51/12 ,  B29C51/261 ,  B29C51/267 ,  B29C66/1312 ,  B29C66/532 ,  B29C66/54 ,  B29C66/61 ,  B29C66/71 ,  B29C66/7234 ,  B29C66/73921 ,  B29C66/81463 ,  B29C66/8242 ,  B29C66/8322 ,  B29C66/83221 ,  B29C69/004 ,  B29C2049/0057 ,  B29K2623/065 ,  B29L2031/7172 ,  B29K2023/065

摘要： A production apparatus includes the following stations juxtaposed in the following sequence: a parison forming station for forming a parison; a built-in part attachment station where opposite sides of a center die provided with a built-in part are held between a pair of molding dies to locate the center die in the molding dies with the parison between the center die and the molding dies, and the built-in part being attached to the parison transferred to the molding dies; a molding station where the molding dies are closed to mold the hollow molded product; and a conveyance station for taking the hollow molded product out of the molding dies and conveying the hollow molded product. The center die is fixed at the built-in part attachment station, and the molding dies are configured to be movable back and forth between the built-in part attachment station and the molding station.

摘要翻译： 制造装置包括以下顺序并列的以下工位：用于形成型坯的型坯成型台; 设置有内置部件的中央模具的相对侧的内置部件附接工位被保持在一对成型模具之间，以使中心模具与中心模具和成型模具之间的型坯定位在成型模具中， 并且内置部件附接到转移到模具的型坯上; 成型台，其中模具封闭以模制中空模制产品; 以及用于将中空成型品从模具中取出并输送中空成型品的输送台。 中心模具固定在内置零件安装台上，并且成型模具构造成可在内置零件安装台和模制工位之间来回移动。

公开(公告)号：US5851065A

公开(公告)日：1998-12-22

申请号：US633189

申请日：1996-04-16

申请人： Sadao Ikeda ,  Makoto Kito ,  Yoshio Taguchi ,  Atsushi Tanaka ,  Shigeki Inoue ,  Naoyuki Murata ,  Shinichi Ninomiya ,  Yoshitaka Kimura

发明人： Sadao Ikeda ,  Makoto Kito ,  Yoshio Taguchi ,  Atsushi Tanaka ,  Shigeki Inoue ,  Naoyuki Murata ,  Shinichi Ninomiya ,  Yoshitaka Kimura

IPC分类号： B29B17/00 ,  B29B17/04 ,  B29C47/40 ,  B29C47/60 ,  B29C47/64 ,  B29C47/76 ,  B29K105/26 ,  C08J11/10 ,  C08J11/12 ,  B29B7/48 ,  B29B7/88

CPC分类号： B29C47/0825 ,  B29B17/00 ,  B29C47/0021 ,  B29C47/38 ,  B29C47/402 ,  B29C47/60 ,  B29C47/6075 ,  B29C47/64 ,  B29C47/767 ,  C08J11/10 ,  B29K2105/26 ,  Y02P20/582 ,  Y02W30/62 ,  Y02W30/702 ,  Y10S264/911

摘要： A process and an apparatus for recycling resin scrap including a thermosetting resin paint film and a thermoplastic resin substrate as its major components, wherein the resin scrap is supplied into a passage of a cylinder, melted, and delivered by screw arrays from an upstream side to a downstream side of the passage of the cylinder, and hydrolyzed by a hydrolyzing agent while forming a highly packed region with a resistor. The resistor restricts the resin scrap to flow from the upstream side to the downstream side in a short period of time, and forms the highly packed region where a contact efficiency is enhanced between the resin scrap and the hydrolyzing agent.

摘要翻译： 一种用于回收树脂废料的方法和装置，包括热固性树脂漆膜和热塑性树脂基材作为其主要成分，其中树脂废料被供应到圆筒的通道中，熔融并由螺旋排列从上游侧输送到 在圆筒的通道的下游侧，并通过水解剂水解，同时形成具有电阻器的高度堆积区域。 电阻器限制树脂废料在短时间内从上游侧流向下游侧，形成树脂废料与水解剂之间接触效率提高的高度堆积区域。