公开(公告)号：US07262278B2

公开(公告)日：2007-08-28

申请号：US10469304

申请日：2002-10-15

申请人： Tomonori Tawara ,  Shiro Kataoka

发明人： Tomonori Tawara ,  Shiro Kataoka

IPC分类号： C12P21/08 ,  C07K16/28

CPC分类号： C07K16/2833 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/734

摘要： This invention provides an anti-HLA-DR monoclonal antibody. This invention relates to an antibody binding to HLA-DR or a functional fragment thereof having (a) life-extending effects in nonhuman animals bearing HLA-DR-expressing cancer cells and (b) activity of suppressing immune responses lower than that of L243, or an antibody binding to HLA-DR or a functional fragment thereof exhibiting immunosuppressive activity equivalent to or higher than that of the mouse anti-HLA-DR monoclonal antibody L243 (ATCC HB-55).

摘要翻译： 本发明提供抗HLA-DR单克隆抗体。 本发明涉及与HLA-DR结合的抗体或其功能片段，其具有（a）带有表达HLA-DR的癌细胞的非人动物的延续效应，和（b）抑制免疫应答的活性低于L243， 或与HLA-DR结合的抗体或其表现与小鼠抗HLA-DR单克隆抗体L243（ATCC HB-55）的免疫抑制活性相当或更高的免疫抑制活性的功能片段。

公开(公告)号：US08552156B2

公开(公告)日：2013-10-08

申请号：US13158622

申请日：2011-06-13

申请人： Shin-ichiro Takayanagi ,  Hitomi Tomura ,  Tomonori Tawara ,  Yoshimasa Inagaki ,  Tsuguo Kubota ,  Koichi Akashi ,  Yoshikane Kikushige

发明人： Shin-ichiro Takayanagi ,  Hitomi Tomura ,  Tomonori Tawara ,  Yoshimasa Inagaki ,  Tsuguo Kubota ,  Koichi Akashi ,  Yoshikane Kikushige

IPC分类号： C07K16/00 ,  A61K39/395

CPC分类号： C07K16/2803 ,  C07K16/2818 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/92 ,  G01N33/56972

摘要： The present invention provides an anti-human TIM-3 antibody having high ADCC activity or antibody fragment thereof by screening a monoclonal antibody or antibody fragment thereof which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure and exhibits ADCC activity; a hybridoma which produces the antibody; a DNA encoding the antibody; a vector comprising the DNA; a transformant which is obtainable by introducing the vector; a method for producing the antibody or the antibody fragment thereof which comprises using the hybridoma or the transformant; a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

摘要翻译： 本发明通过筛选结合TIM-3的胞外区的氨基酸序列的单克隆抗体或其抗体片段或其三维结构，提供具有高ADCC活性的抗人TIM-3抗体或其抗体片段 并展示ADCC活动; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过引入载体可获得的转化体; 包括使用该杂交瘤或转化体的抗体或其抗体片段的制备方法; 包含抗体或其抗体片段的治疗剂和诊断剂作为活性成分。

公开(公告)号：US08492119B2

公开(公告)日：2013-07-23

申请号：US13266603

申请日：2010-04-27

申请人： Tomonori Tawara ,  Shinichiro Takayanagi ,  Yoshimasa Inagaki

发明人： Tomonori Tawara ,  Shinichiro Takayanagi ,  Yoshimasa Inagaki

IPC分类号： C07K16/28 ,  A61K39/395 ,  C12N15/63

CPC分类号： C07K16/2866 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/92 ,  G01N33/57407 ,  G01N33/57426 ,  G01N33/57492 ,  G01N2333/7155

摘要： The present invention provides an antibody to human IL-3Rα chain, which does not inhibit IL-3 signaling and binds to B domain of the human IL-3Rα chain but does not bind to C domain of the human IL-3Rα chain; a composition for preventing or treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood of a subject, which comprises the antibody to human IL-3Rα as an active ingredient; and a method for treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood, which comprises administering, to a subject, a composition comprising the IL-3Rα antibody as an active ingredient.

摘要翻译： 本发明提供了对人IL-3Rα链的抗体，其不抑制IL-3信号传导并结合人IL-3Rα链的B结构域，但不结合人IL-3Rα链的C结构域; 用于预防或治疗其中在人体骨髓或外周血中发现表达IL-3Rα的细胞的血液肿瘤组合物，其包含对人IL-3Rα的抗体作为活性成分; 以及用于治疗其中在骨髓或外周血中发现表达IL-3Rα的细胞的血液肿瘤的方法，其包括向受试者施用包含IL-3Rα抗体的组合物作为活性成分。

公开(公告)号：US20120070448A1

公开(公告)日：2012-03-22

申请号：US13266603

申请日：2010-04-27

申请人： Tomonori Tawara ,  Shinichiro Takayanagi ,  Yoshimasa Inagaki

发明人： Tomonori Tawara ,  Shinichiro Takayanagi ,  Yoshimasa Inagaki

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/28

CPC分类号： C07K16/2866 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/92 ,  G01N33/57407 ,  G01N33/57426 ,  G01N33/57492 ,  G01N2333/7155

摘要： The present invention provides an antibody to human IL-3Rα chain, which does not inhibit IL-3 signaling and binds to B domain of the human IL-3Rα chain but does not bind to C domain of the human IL-3Rα chain; a composition for preventing or treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood of a subject, which comprises the antibody to human IL-3Rα as an active ingredient; and a method for treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood, which comprises administering, to a subject, a composition comprising the IL-3Rα antibody as an active ingredient.

摘要翻译： 本发明提供了对人IL-3Rα链的抗体，其不抑制IL-3信号传导并结合人IL-3Rα链的B结构域但不结合人IL-3Rα链的C结构域; 用于预防或治疗其中在人体骨髓或外周血中发现表达IL-3Rα的细胞的血液肿瘤组合物，其包含对人IL-3Rα的抗体作为活性成分; 以及用于治疗其中在骨髓或外周血中发现表达IL-3Rα的细胞的血液肿瘤的方法，其包括向受试者施用包含IL-3Rα抗体的组合物作为活性成分。