公开(公告)号：US20230158010A1

公开(公告)日：2023-05-25

申请号：US17923183

申请日：2021-05-03

申请人： Tony S. GIBSON ,  Steve SWANN ,  Takeda Pharmaceutical Company Limited

发明人： Tony S. GIBSON ,  Steve SWANN

IPC分类号： A61K31/4545 ,  C07D211/58 ,  C07F9/59 ,  C07D405/14 ,  C07D405/12 ,  A61K31/4468 ,  A61K31/675 ,  A61K31/4525

CPC分类号： A61K31/4545 ,  C07D211/58 ,  C07F9/59 ,  C07D405/14 ,  C07D405/12 ,  A61K31/4468 ,  A61K31/675 ,  A61K31/4525

摘要： Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein m, R1, R2, R3, R4, R5, R6, X1, X2, X3 and X4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with the 5-HT4 receptor.

公开(公告)号：US20210139491A1

公开(公告)日：2021-05-13

申请号：US16622632

申请日：2018-06-19

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Kazuaki TAKAMI ,  Masaki SETO ,  Shinobu SASAKI ,  Haruhi ANDO ,  Masaki OGINO ,  Tomoko OHASHI ,  Toshihiro IMAEDA ,  Ikuo FUJIMORI ,  Yasuhiro TSUKIMI ,  Masami YAMADA ,  Kenichiro SHIMOKAWA ,  Takeshi WAKABAYASHI ,  Masataka MURAKAMI ,  Makoto FUSHIMI ,  Tomohiro OKAWA ,  Jinichi YONEMORI ,  Tomohiro OHASHI ,  Hideo SUZUKI ,  Hironobu MAEZAKI ,  Ayumu SATO ,  Yasutomi ASANO ,  Steve SWANN

IPC分类号： C07D491/048 ,  A61K31/4355 ,  A61P1/10

摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.