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公开(公告)号：US20220096707A1
公开(公告)日：2022-03-31
申请号：US17286181
申请日：2019-10-17
发明人： Shinji Takeoka , Keiko Nakahara , Mamoru Nishiura , Shinya Otsubo , Hajimu Kurumatani , Toru Arakane , Masanobu Takeda , Makoto Nakahara , Kumi Oyama
摘要： A hemostatic material includes a lipid that can accelerate adhesion or aggregation of platelets even if the lipid does not carry a protein or a peptide involved in adhesion or aggregation of platelets such as GPIb and H12 and, to achieve the object, provides a hemostatic material including a water-insoluble base and a lipid supported on a surface of the base, wherein the lipid includes one or two or more anionic lipids.
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公开(公告)号：US20210387943A1
公开(公告)日：2021-12-16
申请号：US17286448
申请日：2019-10-17
发明人： Shinji Takeoka , Keiko Nakahara , Mamoru Nishiura , Shinya Otsubo , Hajimu Kurumatani , Toru Arakane
IPC分类号： C07C233/47 , A61K47/54 , A61K47/64
摘要： A carboxylic acid-type lipid can accelerate adhesion or aggregation of platelets even if the carboxylic acid-type lipid does not carry a protein involved in adhesion or aggregation of platelets or a peptide corresponding to an active site of the protein; a lipid particle and a lipid membrane each include the carboxylic acid-type lipid; and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane. A carboxylic acid-type lipid is selected from carboxylic acid-type lipids represented by formulas (I) to (VI), a lipid particle includes the carboxylic acid-type lipid, a lipid membrane includes the carboxylic acid-type lipid, and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane.
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