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    Contrast media
    3.
    发明授权
    Contrast media 失效
    对比媒体

    公开(公告)号：US5882628A

    公开(公告)日：1999-03-16

    申请号：US470042

    申请日：1995-06-06

    申请人： Torsten Almen ,  Sven Andersson ,  Lars-Goran Wistrand ,  Klaes Golman ,  Oyvind Antonsen ,  Rune Fossheim ,  Unni Nordby Wiggen ,  Hakan Wikstrom ,  Tomas Klingstedt ,  Ib Luenbach ,  Arne Berg ,  Harald Dugstad

    发明人： Torsten Almen ,  Sven Andersson ,  Lars-Goran Wistrand ,  Klaes Golman ,  Oyvind Antonsen ,  Rune Fossheim ,  Unni Nordby Wiggen ,  Hakan Wikstrom ,  Tomas Klingstedt ,  Ib Luenbach ,  Arne Berg ,  Harald Dugstad

    IPC分类号： A61K49/04 ,  C07C33/46 ,  C07C33/48 ,  C07C43/295 ,  C07C49/83 ,  C07C69/02 ,  C07C69/12 ,  C07C233/43 ,  C07C235/16 ,  C07C237/46 ,  C07C275/42 ,  C07C307/10 ,  C07C311/29 ,  C07C317/22 ,  A61K49/00 ,  C07C233/03

    CPC分类号： C07C33/46 ,  A61K49/0433 ,  C07C235/16 ,  C07C237/46 ,  C07C33/483

    摘要： The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C.sub.6 R.sub.5 moeity may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M.sub.1, two or three non-adjacent R groups in each C.sub.6 R.sub.5 moiety being iodine and at least one, and preferably two or three, R groups in each C.sub.6 R.sub.5 moiety being M or M.sub.1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C.sub.6 R.sub.5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M.sub.1 independently represents a C.sub.1-4 alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M.sub.1 moiety; with the proviso that where n is zero either at least one M.sub.1 group other than a hydroxymethyl or 1,2-dihydroxyethyl group is present or then if one hydroxymethyl or 1,2-dihydroxyethyl M.sub.1 group is present at least one nitrogen-attached or hydroxylated-C.sub.3-4 alkyl moiety-containing M group is also present) and isomers thereof.

    摘要翻译： 本发明提供了低分子量的碘化芳基化合物，其可用作式I（I）的X射线造影剂（其中n为0或1，并且其中n为1，每个C 6 R 5的摩尔可以相同或不同;每个 基团R是氢原子，碘原子或亲水部分M或M1，每个C 6 R 5部分中两个或三个不相邻的R基团是碘，并且每个C 6 R 5部分中至少一个，优选两个或三个R基团是 M或M1部分; X表示提供连接两个C 6 R 5部分的1至7个原子链的键或基团，或其中n为0，X表示基团R;每个M独立地为非离子亲水部分;并且每个M1 独立地表示被至少一个羟基取代并且任选地通过羰基，砜或亚砜基团连接到苯环的C 1-4烷基，至少一个R基团是M 1部分;条件是其中n为0， 存在除羟甲基或1,2-二羟乙基之外的至少一个M1基团 如果存在一个羟甲基或1,2-二羟乙基M1基团，则还存在至少一个含氮连接或羟基化的含C3-4烷基部分的M基团）及其异构体。

    Method for production of granules
    4.
    发明授权
    Method for production of granules 失效
    颗粒生产方法

    公开(公告)号：US5258053A

    公开(公告)日：1993-11-02

    申请号：US909964

    申请日：1992-07-07

    申请人： Karl Forwald ,  Rune Fossheim ,  Torbjorn Kjelland

    发明人： Karl Forwald ,  Rune Fossheim ,  Torbjorn Kjelland

    IPC分类号： B22F9/06 ,  B01J2/06 ,  B22F9/08 ,  B22F9/00

    CPC分类号： B22F9/08 ,  B22F2009/0812 ,  B22F2009/086 ,  B22F2009/0864

    摘要： The present invention relates to a method for granulating a stream of molten metal which falls from a launder or the like, down into a liquid cooling bath contained in a tank. The metal stream divides into droplets in the liquid cooling bath and the droplets solidify and form solid granules. The cooling liquid has substantially uniform flow across the tank in a direction that is substantially perpendicular to the falling metal stream. The flow of cooling liquid has a velocity of less than 0.1 m/sec. The distance from the outlets of the launder to the surface of the liquid cooling bath is kept less than 100 times the diameter of the metal stream measured as the metal stream leaves the launder.