公开(公告)号：US07402173B2

公开(公告)日：2008-07-22

申请号：US10364112

申请日：2003-02-10

申请人： Torsten Scheuermann ,  Lutz Stehling

发明人： Torsten Scheuermann ,  Lutz Stehling

IPC分类号： A61F2/06 ,  A61M29/00

CPC分类号： A61L31/022 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2310/00598 ,  A61L31/088 ,  A61L31/18

摘要： In a process for producing a biocompatible stent, a tubular substrate of the stent adapted for diametric expansion has a layer of a noble metal oxide formed over at least the outer surface of greater diameter of the substrate, the substrate being composed of a metal or an alloy thereof that is non-noble or less-noble than the layer's noble metal. An interface region adapted to prevent corrosion and to provide a firm bond between the surface of the substrate and the noble metal oxide layer is established, at least in part, by forming the noble metal oxide layer with a progressively varying concentration of noble metal-to-oxide with depth of the layer such that a surface of pure noble metal and negligible oxide of the layer is in closest proximity to the surface of the substrate. In one embodiment of the process, the interface region is established by forming the surface of pure noble metal and negligible oxide thereof in direct contact with the metal or alloy of the substrate surface. In another, the interface region is established by first creating an oxide of the substrate metal or alloy thereof at the substrate surface, and then forming the noble metal oxide layer as above, but in contact with the substrate metal or alloy oxide. Alternatively, the noble metal oxide layer has no progressively varying concentration but simply overlies an oxide of the substrate metal or alloy.

摘要翻译： 在制造生物相容性支架的方法中，适用于直径膨胀的支架的管状基底具有至少在基底的较大直径的外表面上形成的贵金属氧化物层，该基底由金属或 它的合金是非贵重的或比贵金属低贵的贵金属。 至少部分地通过以逐渐变化的贵金属浓度形成贵金属氧化物层，从而建立适于防止腐蚀并在衬底表面和贵金属氧化物层之间提供牢固结合的界面区域 - 至少 氧化物，其层的深度使得纯贵金属的表面和该层的可忽略的氧化物最接近衬底的表面。 在该方法的一个实施方案中，通过形成纯金属的表面和与基底表面的金属或合金直接接触的可忽略的氧化物的表面来建立界面区。 另一方面，通过首先在基板表面产生基板金属或其合金的氧化物，然后如上所述形成贵金属氧化物层，但与基板金属或合金氧化物接触来建立界面区域。 或者，贵金属氧化物层的浓度没有逐渐变化，而是简单地覆盖基板金属或合金的氧化物。

公开(公告)号：US20080147167A1

公开(公告)日：2008-06-19

申请号：US11952624

申请日：2007-12-07

申请人： Torsten Scheuermann ,  Lutz Stehling

发明人： Torsten Scheuermann ,  Lutz Stehling

IPC分类号： A61F2/06 ,  A61L33/02

CPC分类号： A61L31/022 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2310/00598 ,  A61L31/088 ,  A61L31/18

摘要： In a process for producing a biocompatible stent, a tubular substrate of the stent adapted for diametric expansion has a layer of a noble metal oxide formed over at least the outer surface of greater diameter of the substrate, the substrate being composed of a metal or an alloy thereof that is non-noble or less-noble than the layer's noble metal. An interface region adapted to prevent corrosion and to provide a firm bond between the surface of the substrate and the noble metal oxide layer is established, at least in part, by forming the noble metal oxide layer with a progressively varying concentration of noble metal-to-oxide with depth of the layer such that a surface of pure noble metal and negligible oxide of the layer is in closest proximity to the surface of the substrate. In one embodiment of the process, the interface region is established by forming the surface of pure noble metal and negligible oxide thereof in direct contact with the metal or alloy of the substrate surface. In another, the interface region is established by first creating an oxide of the substrate metal or alloy thereof at the substrate surface, and then forming the noble metal oxide layer as above, but in contact with the substrate metal or alloy oxide. Alternatively, the noble metal oxide layer has no progressively varying concentration but simply overlies an oxide of the substrate metal or alloy.

摘要翻译： 在制造生物相容性支架的方法中，适用于直径膨胀的支架的管状基底具有至少在基底的较大直径的外表面上形成的贵金属氧化物层，该基底由金属或 它的合金是非贵重的或比贵金属低贵的贵金属。 至少部分地通过以逐渐变化的贵金属浓度形成贵金属氧化物层，从而建立适于防止腐蚀并提供衬底的表面与贵金属氧化物层之间牢固结合的界面区域 - 至少 氧化物，其层的深度使得纯贵金属的表面和该层的可忽略的氧化物最接近衬底的表面。 在该方法的一个实施方案中，通过形成纯金属的表面和与基底表面的金属或合金直接接触的可忽略的氧化物的表面来建立界面区域。 另一方面，通过首先在基板表面产生基板金属或其合金的氧化物，然后如上所述形成贵金属氧化物层，但与基板金属或合金氧化物接触来建立界面区域。 或者，贵金属氧化物层的浓度没有逐渐变化，而是简单地覆盖基板金属或合金的氧化物。

公开(公告)号：US07582112B2

公开(公告)日：2009-09-01

申请号：US11952624

申请日：2007-12-07

申请人： Torsten Scheuermann ,  Lutz Stehling

发明人： Torsten Scheuermann ,  Lutz Stehling

IPC分类号： A61F2/06 ,  A61F2/24

CPC分类号： A61L31/022 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2310/00598 ,  A61L31/088 ,  A61L31/18

摘要： In a process for producing a biocompatible stent, a tubular substrate of the stent adapted for diametric expansion has a layer of a noble metal oxide formed over at least the outer surface of greater diameter of the substrate, the substrate being composed of a metal or an alloy thereof that is non-noble or less-noble than the layer's noble metal. An interface region adapted to prevent corrosion and to provide a firm bond between the surface of the substrate and the noble metal oxide layer is established, at least in part, by forming the noble metal oxide layer with a progressively varying concentration of noble metal-to-oxide with depth of the layer such that a surface of pure noble metal and negligible oxide of the layer is in closest proximity to the surface of the substrate. In one embodiment of the process, the interface region is established by forming the surface of pure noble metal and negligible oxide thereof in direct contact with the metal or alloy of the substrate surface. In another, the interface region is established by first creating an oxide of the substrate metal or alloy thereof at the substrate surface, and then forming the noble metal oxide layer as above, but in contact with the substrate metal or alloy oxide. Alternatively, the noble metal oxide layer has no progressively varying concentration but simply overlies an oxide of the substrate metal or alloy.

摘要翻译： 在制造生物相容性支架的方法中，适用于直径膨胀的支架的管状基底具有至少在基底的较大直径的外表面上形成的贵金属氧化物层，该基底由金属或 它的合金是非贵重的或比贵金属低贵的贵金属。 至少部分地通过以逐渐变化的贵金属浓度形成贵金属氧化物层，从而建立适于防止腐蚀并在衬底表面和贵金属氧化物层之间提供牢固结合的界面区域 - 至少 氧化物，其层的深度使得纯贵金属的表面和该层的可忽略的氧化物最接近衬底的表面。 在该方法的一个实施方案中，通过形成纯金属的表面和与基底表面的金属或合金直接接触的可忽略的氧化物的表面来建立界面区域。 另一方面，通过首先在基板表面产生基板金属或其合金的氧化物，然后如上所述形成贵金属氧化物层，但与基板金属或合金氧化物接触来建立界面区域。 或者，贵金属氧化物层的浓度没有逐渐变化，而是简单地覆盖基板金属或合金的氧化物。