公开(公告)号：US20060183664A1

公开(公告)日：2006-08-17

申请号：US10496851

申请日：2002-12-13

申请人： Toshiaki Takizawa ,  Masaki Tamiya ,  Naohiro Saito ,  Toru Kanke ,  Jiro Matsumoto ,  Yasushi Wada ,  Junichi Kawagoe ,  William Ferrell ,  John Lockhart

发明人： Toshiaki Takizawa ,  Masaki Tamiya ,  Naohiro Saito ,  Toru Kanke ,  Jiro Matsumoto ,  Yasushi Wada ,  Junichi Kawagoe ,  William Ferrell ,  John Lockhart

IPC分类号： A61K38/54

CPC分类号： A61K45/06 ,  A61K31/00 ,  Y02A50/423 ,  A61K2300/00

摘要： The present invention provides a pharmaceutical composition by a novel action mechanism without serious side effects for delayed hypersensitivity and a screening method of the same. The invention also provides a novel assay method of inhibitors/suppressive agents of PAR-2. The invention relates to a pharmaceutical composition for delayed hypersensitivity containing one or two or more active ingredients selected from the group consisting of inhibitors of PAR-2 and suppressive agents of PAR-2 gene expression and a pharmaceutically acceptable carrier, and to a method for screening active ingredients for pharmaceutical composition for delayed hypersensitivity by contacting a subject substance with cells expressing PAR-2 and by determining expression or activity of PAR-2. The invention also relates to a method for detecting or quantifying actions of the subject substance for PAR-2 using cells expressing PAR-2 in a culture containing inositol.

摘要翻译： 本发明通过新颖的作用机理提供药物组合物，对迟发性超敏反应没有严重的副作用及其筛选方法。 本发明还提供了PAR-2抑制剂/抑制剂的新型测定方法。 本发明涉及一种用于延迟超敏反应的药物组合物，其含有选自PAR-2的抑制剂和PAR-2基因表达的抑制剂的一种或两种以上活性成分和药学上可接受的载体，以及筛选方法 通过使受试物质与表达PAR-2的细胞接触并通过测定PAR-2的表达或活性来延迟超敏反应的药物组合物的活性成分。 本发明还涉及使用含有肌醇的培养物中表达PAR-2的细胞检测或定量PAR-2的物质的作用的方法。

公开(公告)号：US6117886A

公开(公告)日：2000-09-12

申请号：US357156

申请日：1999-07-19

申请人： Hendrik Timmerman ,  Mingqiang Zang ,  Kazuhiro Onogi ,  Takeo Deushi ,  Masahiro Tamura ,  Tsutomu Tohma ,  Yasushi Wada ,  Jiro Matsumoto ,  Toru Kanke

发明人： Hendrik Timmerman ,  Mingqiang Zang ,  Kazuhiro Onogi ,  Takeo Deushi ,  Masahiro Tamura ,  Tsutomu Tohma ,  Yasushi Wada ,  Jiro Matsumoto ,  Toru Kanke

IPC分类号： A61P11/06 ,  C07D401/14 ,  A61K31/4709

CPC分类号： C07D401/14

摘要： The present invention is directed to a tetrazole derivative represented by the following formula (1) or a salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 independently represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a substituted or unsubstituted alkoxy group, or a substituted or unsubstituted alkanoyloxy group; R.sup.3 represents a hydrogen atom or a substituted or unsubstituted lower alkyl group; A represents a methyleneoxy group or a vinylene group; Z represents a substituted or unsubstituted benzimidazolyl group; and a broken line indicates that there may be a double bond; and to a medicine containing the compound as an active ingredient. The medicine according to the present invention is endowed with excellent antileukotriene activity and antihistaminic activity, and is useful for the prevention and treatment of, for example, asthma.

摘要翻译： 本发明涉及由下式（1）表示的四唑衍生物或其盐：其中R1和R2独立地表示氢原子，羟基，低级烷基，取代或未取代的烷氧基或 取代或未取代的烷酰氧基; R3表示氢原子或取代或未取代的低级烷基; A表示亚甲氧基或亚乙烯基; Z表示取代或未取代的苯并咪唑基; 虚线表示可能存在双键; 和含有该化合物作为活性成分的药物。 根据本发明的药物具有优异的抗白三烯活性和抗组胺活性，可用于预防和治疗例如哮喘。

公开(公告)号：US6107308A

公开(公告)日：2000-08-22

申请号：US158775

申请日：1998-09-23

申请人： Hendrik Timmerman ,  Mingqiang Zang ,  Kazuhiro Onogi ,  Yoshio Takahashi ,  Masahiro Tamura ,  Tsutomu Tohma ,  Yasushi Wada ,  Jiro Matsumoto ,  Toru Kanke

发明人： Hendrik Timmerman ,  Mingqiang Zang ,  Kazuhiro Onogi ,  Yoshio Takahashi ,  Masahiro Tamura ,  Tsutomu Tohma ,  Yasushi Wada ,  Jiro Matsumoto ,  Toru Kanke

IPC分类号： C07D401/14 ,  C07D417/14 ,  C07D487/04 ,  A61K31/47

CPC分类号： C07D401/14 ,  C07D417/14 ,  C07D487/04

摘要： The present invention is directed to a piperidine derivative represented by the following formula (1) or a salt thereof: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 individually represent hydrogen atoms, etc., Y represents ##STR2## B represents a single bond, an alkylene group, --S--CH.sub.2 --, or --CH.dbd.CH--, E represents a single bond or a trimethylene group, Z represents an oxygen atom, etc., and n represents a number between 2 and 5 inclusive; and to a medicine containing the compound. The medicine according to the present invention is endowed with excellent anti-histaminic activity and antileukotriene activity, and exhibits reduced side effects such as drowsiness.

摘要翻译： 本发明涉及由下式（1）表示的哌啶衍生物或其盐：其中R 1，R 2和R 3各自表示氢原子等，Y表示B表示单键，亚烷基， S-CH 2 - 或-CH = CH-，E表示单键或三亚甲基，Z表示氧原子等，n表示2〜5的数。 和含有该化合物的药物。 根据本发明的药物具有优异的抗组胺活性和抗白三烯活性，并且表现出减少的副作用，例如嗜睡。

公开(公告)号：US6121286A

公开(公告)日：2000-09-19

申请号：US158774

申请日：1998-09-23

申请人： Hendrik Timmerman ,  Mingqiang Zang ,  Kazuhiro Onogi ,  Takeo Deushi ,  Masahiro Tamura ,  Tsutomu Tohma ,  Yasushi Wada ,  Jiro Matsumoto ,  Toru Kanke

发明人： Hendrik Timmerman ,  Mingqiang Zang ,  Kazuhiro Onogi ,  Takeo Deushi ,  Masahiro Tamura ,  Tsutomu Tohma ,  Yasushi Wada ,  Jiro Matsumoto ,  Toru Kanke

IPC分类号： A61P11/06 ,  C07D401/14 ,  A61K31/47

CPC分类号： C07D401/14

摘要： The present invention is directed to a tetrazole derivative represented by the following formula (1) or a salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 independently represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a substituted or unsubstituted alkoxy group, or a substituted or unsubstituted alkanoyloxy group; R.sup.3 represents a hydrogen atom or a substituted or unsubstituted lower alkyl group; A represents a methyleneoxy group or a vinylene group; B represents a substituted or unsubstituted quinolyl group, a substituted or unsubstituted quinazolyl group, or a substituted or unsubstituted benzimidazolyl group; and a broken line indicates that there may be a double bond; and to a medicine containing the compound as an active ingredient. The medicine according to the present invention is endowed with excellent antileukotriene activity and antihistaminic activity, and is useful for the prevention and treatment of, for example, asthma.

摘要翻译： 本发明涉及由下式（1）表示的四唑衍生物或其盐：其中R1和R2独立地表示氢原子，羟基，低级烷基，取代或未取代的烷氧基或 取代或未取代的烷酰氧基; R3表示氢原子或取代或未取代的低级烷基; A表示亚甲氧基或亚乙烯基; B表示取代或未取代的喹啉基，取代或未取代的喹唑基，或取代或未取代的苯并咪唑基; 虚线表示可能存在双键; 和含有该化合物作为活性成分的药物。 根据本发明的药物具有优异的抗白三烯活性和抗组胺活性，可用于预防和治疗例如哮喘。

公开(公告)号：US07109057B2

公开(公告)日：2006-09-19

申请号：US10202024

申请日：2002-07-25

申请人： Jiro Matsumoto

发明人： Jiro Matsumoto

IPC分类号： H01L21/66 ,  H01L21/00 ,  H01L21/44 ,  H01L29/40

CPC分类号： H01L21/67126 ,  H01L21/565 ,  H01L2224/05569 ,  H01L2224/05573 ,  H01L2224/16 ,  H01L2224/274

摘要： A sealing apparatus for a semiconductor wafer includes an upper mold and a lower mold. The lower mold includes a recess in which the semiconductor wader is placed, and a pot for introducing resin to the recess. The pot is located under a center area of the recess. Thus, when the resin is introduced in the recess, the resin is spread from the center area of the semiconductor wafer toward the peripheral area.

摘要翻译： 用于半导体晶片的密封装置包括上模和下模。 下模包括其中放置半导体w a的凹部和用于将树脂引入凹部的钵。 锅位于凹槽的中心区域的下方。 因此，当将树脂引入凹部时，树脂从半导体晶片的中心区域向周边区域扩展。

公开(公告)号：US5461768A

公开(公告)日：1995-10-31

申请号：US326057

申请日：1994-10-19

申请人： Jiro Matsumoto ,  Ikuo Yanagisawa

发明人： Jiro Matsumoto ,  Ikuo Yanagisawa

IPC分类号： B21D39/00 ,  B21J15/08 ,  B29C65/60 ,  B21J5/08

CPC分类号： B21J15/08 ,  B21D39/00 ,  Y10S72/70 ,  Y10T29/49915 ,  Y10T29/49943

摘要： An electrical caulking method for a work made from a magnesium or a magnesium alloy wherein a caulking pin integrally projects from a body, wherein an electric caulking apparatus having two opposing electrodes is used. The work is held between the opposing electrodes so that one electrode contacts the caulking pin and the other electrode contacts the body while an electric current is applied between the electrodes and pressure is exerted therebetween, thereby caulking the caulking pin into a desired shape, and providing at least the one electrode that is brought into contact with the caulking pin of the work of a material having low thermal diffusivity and which is difficult to alloy with magnesium. The invention is also concerned with an electrical caulking system using an apparatus having two opposing electrodes for attaching the two members together and the members are positioned together so that the caulking pin is inserted into the inserting hole aligned with the caulking pin and making at least the one electrode which contacts the caulking pin of the work of a material having a low thermal diffusivity and difficult to alloy with magnesium.

摘要翻译： 一种由镁或镁合金制成的工件的电气铆接方法，其中铆接销从主体一体地突出，其中使用具有两个相对电极的电铆接装置。 工件保持在相对的电极之间，使得一个电极接触铆接销，并且另一个电极在电极之间施加电流并接触电极之间施加压力，从而将铆接销铆接成期望的形状，并提供 至少一个电极与具有低热扩散率并且难以与镁合金的材料的工件的铆接销接触。 本发明还涉及使用具有两个相对电极的装置的电气铆接系统，用于将两个部件连接在一起，并且部件被放置在一起，使得铆接销插入到与铆接销对准的插入孔中，并使至少 一个电极与具有低热扩散率并且难以与镁合金的材料的工件的铆接销接触。

公开(公告)号：US08629161B2

公开(公告)日：2014-01-14

申请号：US11993101

申请日：2006-06-20

申请人： Ken Mizuno ,  Jiro Matsumoto

发明人： Ken Mizuno ,  Jiro Matsumoto

IPC分类号： A61K31/47 ,  A61K31/55

CPC分类号： A61K31/551 ,  A61K31/4725 ,  A61K45/06 ,  A61K2300/00

摘要： There is provided a preventive for glaucoma or a preventive or a remedy for ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. A preventive or a remedy for glaucoma comprising a Rho kinase inhibitor and an α1 blocker in combination.

摘要翻译： 提供预防青光眼或用于高眼压症的预防或补救措施，具有有效的低眼压作用和延长的持续时间。 组合包含Rho激酶抑制剂和α1阻断剂的青光眼的预防或补救措施。

公开(公告)号：US20110003026A1

公开(公告)日：2011-01-06

申请号：US12923303

申请日：2010-09-14

申请人： Jiro Matsumoto

发明人： Jiro Matsumoto

IPC分类号： H01L21/56 ,  B29C45/14

CPC分类号： B29C45/14647 ,  B29C45/37 ,  H01L21/565 ,  H01L2224/274 ,  H01L2924/01087

摘要： A sealing apparatus for sealing by resin a semiconductor wafer having semiconductor elements on its surface. The apparatus includes an upper mold and a tower mold having an area where the semiconductor wafer is mounted, the lower mold having an uneven surface in the area and a shock absorber under the lower mold.

摘要翻译： 一种用于通过树脂密封其表面具有半导体元件的半导体晶片的密封装置。 该装置包括具有安装半导体晶片的区域的上模具和塔模具，下模具在该区域中具有不平坦表面，在下模具下方具有减震器。

公开(公告)号：US06682958B2

公开(公告)日：2004-01-27

申请号：US10103889

申请日：2002-03-25

申请人： Jiro Matsumoto

发明人： Jiro Matsumoto

IPC分类号： H01L2144

CPC分类号： B29C45/14647 ,  B29C45/37 ,  H01L21/565 ,  H01L2224/274 ,  H01L2924/01087

摘要： A sealing apparatus for sealing by resin a semiconductor wafer having semiconductor elements on its surface. The apparatus includes an upper mold and a lower mold having an area where the semiconductor wafer is mounted, the lower mold having an uneven surface in the area and a shock absorber under the lower mold.

摘要翻译： 一种用于通过树脂密封其表面具有半导体元件的半导体晶片的密封装置。 该装置包括具有安装半导体晶片的区域的上模具和下模具，下模具在该区域中具有不平坦表面，在下模具下方具有减震器。

公开(公告)号：US20090082338A1

公开(公告)日：2009-03-26

申请号：US11993101

申请日：2006-06-20

申请人： Ken Mizuno ,  Jiro Matsumoto

发明人： Ken Mizuno ,  Jiro Matsumoto

IPC分类号： A61K31/551 ,  A61K31/496 ,  A61P27/06

CPC分类号： A61K31/551 ,  A61K31/4725 ,  A61K45/06 ,  A61K2300/00

摘要： There is provided a preventive for glaucoma or a preventive or a remedy for ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. A preventive or a remedy for glaucoma comprising a Rho kinase inhibitor and an α1 blocker in combination.

摘要翻译： 提供预防青光眼或用于高眼压症的预防或补救措施，具有有效的低眼压作用和延长的持续时间。 组合包含Rho激酶抑制剂和α1阻断剂的青光眼的预防或补救措施。