公开(公告)号：US20170056504A1

公开(公告)日：2017-03-02

申请号：US15254316

申请日：2016-09-01

申请人： Kenneth I. Kohn ,  Toshihisa Kawai

发明人： Kenneth I. Kohn ,  Toshihisa Kawai

IPC分类号： A61K47/26 ,  A61K9/00 ,  C07K16/40

CPC分类号： A61K47/26 ,  A61K47/44 ,  A61K2039/505 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： A composition for extending the half-life of a crystalline antibody, including synergistically effective amounts of a half-life-extending compound and a crystalline antibody. A composition for extending the half-life of a crystalline antibody including synergistically effective amounts of lactulose and a crystalline anti-PCSK9 antibody. A method of extending the half-life of a crystalline antibody, by administering a synergistically effective amount of a half-life-extending compound and a crystalline antibody to an individual, and extending the half-life of the crystalline antibody. A method of promoting antibody recycling by affecting a receptor for an antibody to recycle the antibody.

摘要翻译： 一种用于延长结晶抗体半衰期的组合物，包括协同有效量的半衰期延长化合物和结晶抗体。 一种用于延长结晶抗体的半衰期的组合物，包括协同有效量的乳果糖和结晶抗PCSK9抗体。 通过对个体施用协同有效量的半衰期延长的化合物和结晶抗体并延长结晶抗体的半衰期，延长结晶抗体的半衰期的方法。 通过影响抗体的受体以再循环抗体来促进抗体再循环的方法。

公开(公告)号：US20150335615A1

公开(公告)日：2015-11-26

申请号：US14758903

申请日：2014-01-06

申请人： Toshihisa Kawai ,  Kenneth I. Kohn

发明人： Toshihisa Kawai ,  Kenneth I. Kohn

IPC分类号： A61K31/40 ,  A61K39/395 ,  A61K33/00 ,  A61K31/7016

CPC分类号： A61K31/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/7016 ,  A61K33/00 ,  A61K39/3955 ,  C07K16/40 ,  A61K2300/00

摘要： A composition for treating high cholesterol, including synergistically effective amounts of a cholesterol-lowering agent and a lipid metabolism-altering compound chosen from a non-absorbable sugar, a compound that converts NH3 to NH4+, a hydrogen-generating compound, and combinations thereof. A composition for treating high cholesterol, including synergistically effective amounts of a statin chosen from atorvastatin, cerivastatin, fluvastain, lovastatin, mevastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin, and lactulose. A method of lowering cholesterol by administering a synergistically effective amount of the composition to an individual, and lowering cholesterol in the individual.

摘要翻译： 一种用于治疗高胆固醇的组合物，包括协同有效量的胆固醇降低剂和选自不可吸收糖，将NH 3转化成NH 4 +的化合物，产生氢的化合物及其组合的脂质代谢改变化合物。 用于治疗高胆固醇的组合物，包括协同有效量的选自阿伐他汀，西立伐他汀，氟伐他汀，洛伐他汀，美伐他汀，匹伐他汀，普伐他汀，罗苏伐他汀和辛伐他汀和乳果糖的他汀类药物。 通过向个体施用协同有效量的组合物并降低个体中的胆固醇来降低胆固醇的方法。

公开(公告)号：US20160317575A1

公开(公告)日：2016-11-03

申请号：US15187339

申请日：2016-06-20

申请人： Toshihisa Kawai ,  Kenneth I. Kohn

发明人： Toshihisa Kawai ,  Kenneth I. Kohn

IPC分类号： A61K33/00 ,  A61K31/192 ,  A61K31/635 ,  A61K31/715 ,  A61K9/08 ,  A61K45/06 ,  A61K31/197 ,  A61K31/7016 ,  A61K31/365

CPC分类号： A61K31/7016 ,  A61K9/08 ,  A61K9/167 ,  A61K9/48 ,  A61K31/192 ,  A61K31/197 ,  A61K31/365 ,  A61K31/40 ,  A61K31/415 ,  A61K31/635 ,  A61K31/7004 ,  A61K31/715 ,  A61K31/733 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.

公开(公告)号：US09925204B2

公开(公告)日：2018-03-27

申请号：US15187339

申请日：2016-06-20

申请人： Toshihisa Kawai ,  Kenneth I. Kohn

发明人： Toshihisa Kawai ,  Kenneth I. Kohn

IPC分类号： A61K9/48 ,  A61K31/7016 ,  A61K45/06 ,  A61K31/192 ,  A61K31/197 ,  A61K31/365 ,  A61K31/40 ,  A61K31/635 ,  A61K31/7004 ,  A61K31/733 ,  A61K33/00 ,  A61K9/16 ,  A61K31/415 ,  A61K9/08 ,  A61K31/715

CPC分类号： A61K31/7016 ,  A61K9/08 ,  A61K9/167 ,  A61K9/48 ,  A61K31/192 ,  A61K31/197 ,  A61K31/365 ,  A61K31/40 ,  A61K31/415 ,  A61K31/635 ,  A61K31/7004 ,  A61K31/715 ,  A61K31/733 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.