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1.发明授权公开(公告)号：US09925204B2
公开(公告)日：2018-03-27
申请号：US15187339
申请日：2016-06-20
申请人： Toshihisa Kawai , Kenneth I. Kohn
发明人： Toshihisa Kawai , Kenneth I. Kohn
IPC分类号： A61K9/48 , A61K31/7016 , A61K45/06 , A61K31/192 , A61K31/197 , A61K31/365 , A61K31/40 , A61K31/635 , A61K31/7004 , A61K31/733 , A61K33/00 , A61K9/16 , A61K31/415 , A61K9/08 , A61K31/715
CPC分类号： A61K31/7016 , A61K9/08 , A61K9/167 , A61K9/48 , A61K31/192 , A61K31/197 , A61K31/365 , A61K31/40 , A61K31/415 , A61K31/635 , A61K31/7004 , A61K31/715 , A61K31/733 , A61K33/00 , A61K45/06 , A61K2300/00
摘要： A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.
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2.发明申请公开(公告)号：US20160317575A1
公开(公告)日：2016-11-03
申请号：US15187339
申请日：2016-06-20
申请人： Toshihisa Kawai , Kenneth I. Kohn
发明人： Toshihisa Kawai , Kenneth I. Kohn
IPC分类号： A61K33/00 , A61K31/192 , A61K31/635 , A61K31/715 , A61K9/08 , A61K45/06 , A61K31/197 , A61K31/7016 , A61K31/365
CPC分类号： A61K31/7016 , A61K9/08 , A61K9/167 , A61K9/48 , A61K31/192 , A61K31/197 , A61K31/365 , A61K31/40 , A61K31/415 , A61K31/635 , A61K31/7004 , A61K31/715 , A61K31/733 , A61K33/00 , A61K45/06 , A61K2300/00
摘要： A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.
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公开(公告)号：US20100330070A1
公开(公告)日：2010-12-30
申请号：US12762212
申请日：2010-04-16
IPC分类号： A61K39/395 , C07K14/00 , A61K39/00 , C12P21/04 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , A61K38/16 , C12Q1/68 , G01N33/53 , A61P37/00
CPC分类号： A61K31/192 , A61K39/0005 , C07K14/47 , C07K16/18
摘要： The present invention relates to new methods for making antibodies that involves chemically modifying the antigen with methylglyoxal. The present invention further relates to antibodies made in this manner, and include antibodies specific to LL-37. The present invention pertains to assays that utilize anti-LL-37 antibodies and assess compounds that stimulate LL-37 production. Such compounds are useful in antimicrobial compositions.
摘要翻译： 本发明涉及用于制备涉及用甲基乙二醛化学修饰抗原的抗体的新方法。 本发明还涉及以这种方式制备的抗体，并且包括对LL-37特异的抗体。 本发明涉及利用抗LL-37抗体并评估刺激LL-37生产的化合物的测定法。 这些化合物可用于抗微生物组合物。
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公开(公告)号：US20100330001A1
公开(公告)日：2010-12-30
申请号：US12762234
申请日：2010-04-16
IPC分类号： A61K9/68 , C12N5/00 , A61P31/04 , A61P1/02 , A61P31/10 , A61P1/04 , A61K38/43 , A61K31/192 , A61K31/235 , A61K31/353 , G01N33/50 , G01N33/53 , C07C65/05 , G01N33/543 , C12Q1/68 , C07C69/88 , C07D311/62
CPC分类号： A61K31/192 , A61K39/0005 , C07K14/47 , C07K16/18
摘要： The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.
摘要翻译： 本发明涉及包含三羟基苯甲酸酯衍生物的口服抗菌组合物，例如可用于治疗牙龈疾病（例如牙龈炎或牙周炎）和使用这些组合物的方法。
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公开(公告)号：US20170056504A1
公开(公告)日：2017-03-02
申请号：US15254316
申请日：2016-09-01
申请人： Kenneth I. Kohn , Toshihisa Kawai
发明人： Kenneth I. Kohn , Toshihisa Kawai
CPC分类号： A61K47/26 , A61K47/44 , A61K2039/505 , C07K16/32 , C07K16/40 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： A composition for extending the half-life of a crystalline antibody, including synergistically effective amounts of a half-life-extending compound and a crystalline antibody. A composition for extending the half-life of a crystalline antibody including synergistically effective amounts of lactulose and a crystalline anti-PCSK9 antibody. A method of extending the half-life of a crystalline antibody, by administering a synergistically effective amount of a half-life-extending compound and a crystalline antibody to an individual, and extending the half-life of the crystalline antibody. A method of promoting antibody recycling by affecting a receptor for an antibody to recycle the antibody.
摘要翻译： 一种用于延长结晶抗体半衰期的组合物，包括协同有效量的半衰期延长化合物和结晶抗体。 一种用于延长结晶抗体的半衰期的组合物，包括协同有效量的乳果糖和结晶抗PCSK9抗体。 通过对个体施用协同有效量的半衰期延长的化合物和结晶抗体并延长结晶抗体的半衰期，延长结晶抗体的半衰期的方法。 通过影响抗体的受体以再循环抗体来促进抗体再循环的方法。
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公开(公告)号：US08728456B2
公开(公告)日：2014-05-20
申请号：US13386950
申请日：2010-08-02
IPC分类号： A61K39/35 , A61K39/00 , A61K38/20 , A61K38/19 , A61P37/04 , A61P37/06 , A61P3/10 , A61P29/00 , A61P37/08
CPC分类号： A61K39/0008 , A61K39/0011 , A61K39/102 , A61K39/35 , A61K39/39 , A61K2039/5158 , A61K2039/55522 , A61K2039/55561 , A61K2039/577 , A61K2039/70
摘要： Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.
摘要翻译： 生物材料系统，例如凝胶支架，用于体内募集免疫细胞并促进其向非炎症表型的活化，从而导致炎症的抑制。 组合物和方法可用于降低自身免疫，慢性炎症，过敏和牙周病的严重性。
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公开(公告)号：US08399220B2
公开(公告)日：2013-03-19
申请号：US12762234
申请日：2010-04-16
IPC分类号： C12P21/04
CPC分类号： A61K31/192 , A61K39/0005 , C07K14/47 , C07K16/18
摘要： The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.
摘要翻译： 本发明涉及包含三羟基苯甲酸酯衍生物的口服抗菌组合物，例如可用于治疗牙龈疾病（例如牙龈炎或牙周炎）和使用这些组合物的方法。
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公开(公告)号：US20070261950A1
公开(公告)日：2007-11-15
申请号：US11678129
申请日：2007-02-23
申请人： Kimihiro Sato , Toshihisa Kawai
发明人： Kimihiro Sato , Toshihisa Kawai
IPC分类号： C01B3/00
CPC分类号： C02F1/4618 , C02F2303/04 , Y02E60/324
摘要： A drink for promoting health benefits to the user, the drink including hypochlorite free ionized water. Hypochlorite free ionized water and a method of forming hypochlorite free water by dissolving a non-hypochlorite generating salt in water and electrolyzing the water containing the dissolved salt.
摘要翻译： 用于促进使用者健康的饮料，饮料中含有次氯酸盐的电离水。 不含次氯酸盐的离子水和通过将非次氯酸盐生成的盐溶解在水中并电解含有溶解盐的水来形成不含次氯酸盐的水的方法。
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9.发明申请CHOLESTEROL-LOWERING COMPOUNDS IN COMBINATION WITH LIPID METABOLISM-ALTERING COMPOUNDS OF NON-ABSORBABLE SUGARS, COMPOUNDS THAT CONVERT NH3 TO NH4+, OR HYDROGEN-GENERATING COMPOUNDS FOR THE TREATMENT OF HIGH CHOLESTEROL AND INFLAMMATION 审中-公开与不可吸收的糖的脂肪代谢改变化合物组合的胆固醇降低化合物，将NH 3转化成NH 4 +或氢化物的化合物用于治疗高胆固醇和炎症的化合物公开(公告)号：US20150335615A1
公开(公告)日：2015-11-26
申请号：US14758903
申请日：2014-01-06
申请人： Toshihisa Kawai , Kenneth I. Kohn
发明人： Toshihisa Kawai , Kenneth I. Kohn
IPC分类号： A61K31/40 , A61K39/395 , A61K33/00 , A61K31/7016
CPC分类号： A61K31/40 , A61K31/22 , A61K31/366 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/7016 , A61K33/00 , A61K39/3955 , C07K16/40 , A61K2300/00
摘要： A composition for treating high cholesterol, including synergistically effective amounts of a cholesterol-lowering agent and a lipid metabolism-altering compound chosen from a non-absorbable sugar, a compound that converts NH3 to NH4+, a hydrogen-generating compound, and combinations thereof. A composition for treating high cholesterol, including synergistically effective amounts of a statin chosen from atorvastatin, cerivastatin, fluvastain, lovastatin, mevastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin, and lactulose. A method of lowering cholesterol by administering a synergistically effective amount of the composition to an individual, and lowering cholesterol in the individual.
摘要翻译： 一种用于治疗高胆固醇的组合物，包括协同有效量的胆固醇降低剂和选自不可吸收糖，将NH 3转化成NH 4 +的化合物，产生氢的化合物及其组合的脂质代谢改变化合物。 用于治疗高胆固醇的组合物，包括协同有效量的选自阿伐他汀，西立伐他汀，氟伐他汀，洛伐他汀，美伐他汀，匹伐他汀，普伐他汀，罗苏伐他汀和辛伐他汀和乳果糖的他汀类药物。 通过向个体施用协同有效量的组合物并降低个体中的胆固醇来降低胆固醇的方法。
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公开(公告)号：US08992998B2
公开(公告)日：2015-03-31
申请号：US13820209
申请日：2011-09-02
申请人： Toshihisa Kawai , Mikihito Kajiya , Kimihiro Sato
发明人： Toshihisa Kawai , Mikihito Kajiya , Kimihiro Sato
CPC分类号： A61K33/00 , A23L2/52 , C25B1/04 , Y02E60/366
摘要： A method of treating inflammation in a subject by administering a composition including hydrogen, releasing hydrogen in the subject, suppressing mitogen-activated protein kinase (MAPK) phosphorylation and upregulating expression of MKP-1, and down-regulating inflammatory responses of monocyte lineage cells.
摘要翻译： 通过施用包含氢的组合物，释放受试者中的氢，抑制丝裂原活化蛋白激酶（MAPK）磷酸化和上调MKP-1的表达以及下调单核细胞谱系细胞的炎症反应来治疗受试者的炎症的方法。
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