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1.发明授权
公开(公告)号：US4127647A
公开(公告)日：1978-11-28
申请号：US842197
申请日：1977-10-14
申请人： Toyomi Sato , Toshiyuki Kobayashi , Takeshi Mayama , Akira Okada
发明人： Toyomi Sato , Toshiyuki Kobayashi , Takeshi Mayama , Akira Okada
摘要： Amorphous solids of macrolide antibiotics which are stable with the passage of time are prepared by dissolving a macrolide antibiotic and a cellulose polymer selected from the group consisting of ethyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose as a stabilizing substance in a volatile organic solvent selected from the group consisting of dichloromethane, 1,1,1-trichloroethane and chloroform and spray drying the resulting solution.
摘要翻译： 通过将大环内酯类抗生素和选自乙基纤维素，羟丙基纤维素和羟丙基甲基纤维素的纤维素聚合物作为稳定物质溶解在选自以下的挥发性有机溶剂中来制备大环内酯类抗生素随时间稳定的无定形固体： 由二氯甲烷，1,1,1-三氯乙烷和氯仿组成的组，喷雾干燥得到的溶液。
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公开(公告)号：US4101651A
公开(公告)日：1978-07-18
申请号：US655026
申请日：1976-02-03
申请人： Toshiyuki Kobayashi , Akio Okada , Takeshi Mayama , Akira Okada
发明人： Toshiyuki Kobayashi , Akio Okada , Takeshi Mayama , Akira Okada
CPC分类号： A61K9/1652 , A61K9/1611 , A61K9/1635
摘要： A process for preparing preparations for oral administration which do not have a bitter taste which comprises either dissolving a bitter taste-masking substance at a high concentration in a solvent to be used for dissolving or suspending a bitter active ingredient and adding the active ingredient to the resulting solution followed by kneading, or kneading a solution or suspension in which a bitter active ingredient has been dissolved or suspended with the bitter taste-masking substance, adding silicic acid anhydride to the resulting kneaded substance to form a powder and granulating the powder using a solution of the bitter taste-masking substance in a fluidized bed granulator.
摘要翻译： 一种制备不具有苦味的口服制剂的方法，其包括将高浓度的苦味掩味物质溶解在用于溶解或悬浮苦味活性成分的溶剂中，并将活性成分加入到 然后捏合或捏合其中苦味活性成分已经溶解或悬浮的苦味掩蔽物质的溶液或悬浮液，向所得捏合物中加入硅酸酐以形成粉末，并使用 苦味掩味物质在流化床造粒机中的溶液。
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公开(公告)号：US3962419A
公开(公告)日：1976-06-08
申请号：US496299
申请日：1974-08-09
申请人： Takeshi Mayama , Toshiyuki Kobayashi , Akira Okada
发明人： Takeshi Mayama , Toshiyuki Kobayashi , Akira Okada
摘要： This invention relates to an antibiotic preparation comprising a macrolide antibiotic, which is highly stabilized against an acidic solution or acidic substance because of the presence of a polymer component incorporated with the macrolide antibiotic by specific solvent treatment, and to a process for the production of such antibiotic preparation. The antibiotic preparation of this invention overcomes the defect of macrolide antibiotics that they are easily decomposed upon contact with an acidic solution or acidic substance.
摘要翻译： 本发明涉及包含大环内酯抗生素的抗生素制剂，由于通过特异性溶剂处理与大环内酯类抗生素结合的聚合物成分的存在，其对酸性溶液或酸性物质高度稳定，以及生产这种 抗生素制剂。 本发明的抗生素制剂克服了大环内酯类抗生素的缺点，它们在与酸性溶液或酸性物质接触时容易分解。
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公开(公告)号：US3943238A
公开(公告)日：1976-03-09
申请号：US410334
申请日：1973-10-29
CPC分类号： A61K9/4866 , A61K9/485 , A61K9/4858 , Y10S514/962
摘要： A method for the preparation of gelatin capsules having a good disintegrating property, in which a material selected from the group consisting of a protein, an amino acid, a substance having at least one amino group, an antioxidant, monobasic sodium phosphate, and the mixture thereof is added to the encapsulated contents.
摘要翻译： 一种制备具有良好崩解性质的明胶胶囊的方法，其中选自蛋白质，氨基酸，具有至少一个氨基的物质，抗氧化剂，磷酸二氢钠，以及混合物 将其添加到封装的内容物中。
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