公开(公告)号：US5532267A

公开(公告)日：1996-07-02

申请号：US215785

申请日：1994-03-22

申请人： Toyoo Nakayama ,  Seizo Taira ,  Hiroyuki Kawamura ,  Masaoki Shibuya ,  Masahiro Iwaki

发明人： Toyoo Nakayama ,  Seizo Taira ,  Hiroyuki Kawamura ,  Masaoki Shibuya ,  Masahiro Iwaki

IPC分类号： C07D307/68 ,  C07D407/12 ,  A61K31/335 ,  A61K31/34 ,  C07D307/46 ,  C07D317/14

CPC分类号： C07D407/12 ,  C07D307/68

摘要： Amidinonaphthyl furancarboxylate derivatives of the formula I ##STR1## wherein A is a single bond or A denotes (a) a phenyl group, cyclopentyl group, or cyclohexyl group,(b) an alkenylphenyl group, alkylphenyl group, phenylalkenyl group, or phenylalkyl group wherein alkyl is C.sub.1 to C.sub.7 alkyl and alkenyl is C.sub.2 to C.sub.7 alkenyl,(c) a C.sub.1 to C.sub.18 alkyl or C.sub.2 to C.sub.7 alkenyl group which may be substituted by one or two substituents selected from C.sub.1 to C.sub.5 alkyl groups and quanidino groups, wherein an alkyl substituent together with the carbon atom to which it is attached may form a cycloalkyl ring having from 3 to 6 carbon atoms, or said C.sub.1 to C.sub.5 alkyl may itself be substituted by a C.sub.3 to C.sub.6 cycloalkyl ring, or(d) --(CH.sub.2).sub.n --NH--CO--(CH.sub.2).sub.n' wherein n and n' may be the same or different and represent an integer from 1 to 4; andwherein R denotes(e) a hydroxyl group,(f) a C.sub.1 to C.sub.7 alkoxy group which may be mono- or disubstituted by C.sub.1 to C.sub.5 alkyl,(g) a phenyl-C.sub.1 -C.sub.4 alkoxy group,(h) --OAl(OH).sub.2,(i) an amino group,(j) ##STR2## or (k) ##STR3## and pharmaceutically acceptable acid addition salts thereof, useful as pharmaceuticals.

摘要翻译： 其中A是单键或A表示（a）苯基，环戊基或环己基，（b）烯基苯基，烷基苯基，苯基烯基，（C 1 -C 6）烷氧基羰基， 或苯基烷基，其中烷基是C1-C7烷基，烯基是C2-C7链烯基，（c）C1-C18烷基或C2-C7烯基，其可以被一个或两个选自C1-C5烷基和喹啉基的取代基取代 基团，其中烷基取代基与其所连接的碳原子一起可以形成具有3至6个碳原子的环烷基环，或所述C1至C5烷基本身可以被C 3至C 6环烷基环取代，或（d ） - （CH 2）n -NH-CO-（CH 2）n'，其中n和n'可以相同或不同，表示1至4的整数; 并且其中R表示（e）羟基，（f）可被C1至C5烷基单或二取代的C1至C7烷氧基，（g）苯基-C1-C4烷氧基，（h）-OAl（ OH）2，（i）可用作药物的氨基，（j）和/或其药学上可接受的酸加成盐。