公开(公告)号：US20220218612A1

公开(公告)日：2022-07-14

申请号：US17611020

申请日：2020-05-14

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Frank DeRosa ,  Michael Hearlein ,  Ashish Sarode ,  Zarna Patel ,  Rebecca L. Ball ,  Natalia Vargas Montoya ,  Priyal Patel ,  Asad Khanmohammed

IPC: A61K9/127 ,  A61K9/00 ,  A61K31/7088 ,  A61K9/16

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process for enhanced encapsulation of messenger RNA (mRNA) in lipid nanoparticles comprising a step of heating the mRNA-encapsulated lipid nanoparticles in a drug product formulation solution.