-
公开(公告)号：US20220218612A1
公开(公告)日：2022-07-14
申请号：US17611020
申请日：2020-05-14
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Michael Hearlein , Ashish Sarode , Zarna Patel , Rebecca L. Ball , Natalia Vargas Montoya , Priyal Patel , Asad Khanmohammed
IPC: A61K9/127 , A61K9/00 , A61K31/7088 , A61K9/16
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process for enhanced encapsulation of messenger RNA (mRNA) in lipid nanoparticles comprising a step of heating the mRNA-encapsulated lipid nanoparticles in a drug product formulation solution.
-
公开(公告)号：US20250025430A1
公开(公告)日：2025-01-23
申请号：US18753746
申请日：2024-06-25
Applicant: TRANSLATE BIO, INC.
Inventor： Shrirang Karve , Frank DeRosa , Ashish Sarode , Natalia Vargas Montoya , Priyal Patel
IPC: A61K9/51 , A61K31/7105 , B82Y5/00 , B82Y40/00
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
-
公开(公告)号：US12053551B2
公开(公告)日：2024-08-06
申请号：US17129666
申请日：2020-12-21
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Ashish Sarode , Natalia Vargas Montoya , Priyal Patel
IPC: A61K9/51 , A61K31/7105 , B82Y5/00 , B82Y40/00
CPC classification number: A61K9/5192 , A61K31/7105 , B82Y5/00 , B82Y40/00
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
-
Patent Agency Ranking
公开(公告)号：US12144871B2
公开(公告)日：2024-11-19
申请号：US16936909
申请日：2020-07-23
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Michael Heartlein , Natalia Vargas Montoya , Priyal Patel , Ashish Sarode
Abstract: The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs). In some embodiments, the present invention provides mRNA-LNPs with exceptional stability and is particularly useful in cases where LNPs comprising low or no PEG-modified lipids are desired.
-
公开(公告)号：US20220287966A1
公开(公告)日：2022-09-15
申请号：US17534956
申请日：2021-11-24
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Ashish Sarode , Natalia Vargas Montoya , Priyal Patel , Frank DeRosa
Abstract: The present invention provides, among other things, a liquid lipid nanoparticle (LNP) formulation encapsulating mRNA encoding a peptide or polypeptide, that is resistant to aggregation and to mRNA degradation following multiple rounds of freezing at −20° C. and rethawing.
-
公开(公告)号：US20210378962A1
公开(公告)日：2021-12-09
申请号：US17286113
申请日：2019-10-18
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Priyal Patel , Natalia Vargas Montoya , Frank DeRosa , Michael Heartlein
IPC: A61K9/127 , A61K31/7105
Abstract: The present invention provides, among other things, a process of encapsulating messenger RNA (mRNA) in liposomes comprising a. providing a first stream comprising an mRNA solution at a first controlled flow rate, b. providing a second stream comprising a lipid solution at a second controlled flow rate, and c. mixing the first stream and the second stream to form mRNA-encapsulated liposomes, wherein the first controlled flow rate and the second controlled flow rate are achieved without use of a pump.
-
公开(公告)号：US20210186890A1
公开(公告)日：2021-06-24
申请号：US17129666
申请日：2020-12-21
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Ashish Sarode , Natalia Vargas Montoya , Priyal Patel
IPC: A61K9/51 , A61K31/7105 , B82Y5/00 , B82Y40/00
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
-
公开(公告)号：US20210046192A1
公开(公告)日：2021-02-18
申请号：US16936909
申请日：2020-07-23
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Michael Heartlein , Natalia Vargas Montoya , Priyal Patel , Ashish Sarode
Abstract: The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs). In some embodiments, the present invention provides mRNA-LNPs with exceptional stability and is particularly useful in cases where LNPs comprising low or no PEG-modified lipids are desired.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.016 seconds)
