公开(公告)号：US20220133631A1

公开(公告)日：2022-05-05

申请号：US17450628

申请日：2021-10-12

Applicant: Translate Bio, Inc.

Inventor： Monic Shah ,  Travis Jeanotte ,  Yi Zhang ,  Shrirang Karve ,  Kimberly Gillis ,  Frank DeRosa

IPC: A61K9/127 ,  A61K31/7105

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing an mRNA solution containing low citrate concentration and a lipid solution at an ambient temperature. Thus, the present invention provides an effective, reliable, energy-saving and cost-effective method of encapsulating mRNA into lipid nanoparticles.

公开(公告)号：US20220110884A1

公开(公告)日：2022-04-14

申请号：US17450629

申请日：2021-10-12

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Travis Jeanotte ,  Monic Shah ,  Yi Zhang ,  Kimberly Gillis ,  Frank DeRosa

IPC: A61K9/51 ,  A61K9/127

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing an mRNA solution containing low citrate concentration and a lipid solution at an ambient temperature. Thus, the present invention provides an effective, reliable, energy-saving and cost-effective method of encapsulating mRNA into lipid nanoparticles.